Unipolar brush cells form a glutamatergic projection system within the mouse cerebellar cortex

2001 ◽  
Vol 434 (3) ◽  
pp. 329-341 ◽  
Author(s):  
Maria Grazia Nunzi ◽  
Susanne Birnstiel ◽  
Bula J. Bhattacharyya ◽  
N. Traverse Slater ◽  
Enrico Mugnaini
Keyword(s):  
Cerebellar Cortex ◽  
Brush Cells ◽  
Projection System ◽  
Unipolar Brush Cells

scholarly journals Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex

2021 ◽  
Author(s):  
Chong Guo ◽  
Stephanie Rudolph ◽  
Morgan E. Neuwirth ◽  
Wade G. Regehr
Keyword(s):  
Purkinje Cell ◽  
Cerebellar Cortex ◽  
Mossy Fiber ◽  
Input Output ◽  
Brush Cells ◽  
Unipolar Brush Cells ◽  
Input Layer ◽  
Inhibitory Feedback ◽  
Almost All ◽  
Control Balance

AbstractCircuitry of the cerebellar cortex is regionally and functionally specialized. Unipolar brush cells (UBCs), and Purkinje cell (PC) synapses made by axon collaterals in the granular layer, are both enriched in areas that control balance and eye-movement. Here we find a link between these specializations: PCs preferentially inhibit mGluR1-expressing UBCs that respond to mossy fiber inputs with long lasting increases in firing, but PCs do not inhibit mGluR1-lacking UBCs. PCs inhibit about 29% of mGluR1-expressing UBCs by activating GABAA receptors (GABAARs) and inhibit almost all mGluR1-expressing UBCs by activating GABABRs. PC to UBC synapses allow PC output to regulate the input layer of the cerebellar cortex in diverse ways. GABAAR-mediated feedback is fast, unreliable, noisy, and suited to linearizing input-output curves and decreasing gain. Slow GABABR-mediated inhibition allows elevated PC activity to sharpen the input-output transformation of UBCs, and allows dynamic inhibitory feedback of mGluR1-expressing UBCs.

scholarly journals Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Chong Guo ◽  
Stephanie Rudolph ◽  
Morgan E Neuwirth ◽  
Wade G Regehr
Keyword(s):  
Purkinje Cell ◽  
Cerebellar Cortex ◽  
Metabotropic Glutamate Receptor ◽  
Mossy Fiber ◽  
Brush Cells ◽  
Metabotropic Glutamate ◽  
Unipolar Brush Cells ◽  
Input Layer ◽  
Almost All ◽  
Control Balance

Circuitry of the cerebellar cortex is regionally and functionally specialized. Unipolar brush cells (UBCs), and Purkinje cell (PC) synapses made by axon collaterals in the granular layer, are both enriched in areas that control balance and eye movement. Here, we find a link between these specializations in mice: PCs preferentially inhibit metabotropic glutamate receptor type 1 (mGluR1)-expressing UBCs that respond to mossy fiber (MF) inputs with long lasting increases in firing, but PCs do not inhibit mGluR1-lacking UBCs. PCs inhibit about 29% of mGluR1-expressing UBCs by activating GABAA receptors (GABAARs) and inhibit almost all mGluR1-expressing UBCs by activating GABAB receptors (GABABRs). PC to UBC synapses allow PC output to regulate the input layer of the cerebellar cortex in diverse ways. Based on optogenetic studies and a small number of paired recordings, GABAAR-mediated feedback is fast and unreliable. GABABR-mediated inhibition is slower and is sufficiently large to strongly influence the input-output transformations of mGluR1-expressing UBCs.

Postnatal development of unipolar brush cells in the cerebellar cortex of cat

2000 ◽  
Vol 61 (1) ◽  
pp. 107-115 ◽  
Author(s):  
J�zsef Tak�cs ◽  
Zsolt A. Borosty�nk�i ◽  
Eleon�ra Veisenberger ◽  
Csaba Vastagh ◽  
J�lianna V�g ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Cerebellar Cortex ◽  
Brush Cells ◽  
Unipolar Brush Cells

scholarly journals Visuo-Vestibular Information Processing by Unipolar Brush Cells in the Rabbit Flocculus

2015 ◽  
Vol 14 (5) ◽  
pp. 578-583 ◽  
Author(s):  
Robert A. Hensbroek ◽  
Tom J. H. Ruigrok ◽  
Boeke J. van Beugen ◽  
Jun Maruta ◽  
John I. Simpson
Keyword(s):  
Information Processing ◽  
Brush Cells ◽  
Vestibular Information ◽  
Unipolar Brush Cells

scholarly journals Electrophysiological, Morphological, and Topological Properties of Two Histochemically Distinct Subpopulations of Cerebellar Unipolar Brush Cells

2012 ◽  
Vol 11 (4) ◽  
pp. 1012-1025 ◽  
Author(s):  
Jin-Ah Kim ◽  
Gabriella Sekerková ◽  
Enrico Mugnaini ◽  
Marco Martina
Keyword(s):  
Topological Properties ◽  
Brush Cells ◽  
Unipolar Brush Cells
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