Erbb transmembrane tyrosine kinase receptors are differentially expressed throughout the adult rat central nervous system

2001 ◽  
Vol 433 (1) ◽  
pp. 86-100 ◽  
Author(s):  
Kimberly M. Gerecke ◽  
J. Michael Wyss ◽  
Irina Karavanova ◽  
Andres Buonanno ◽  
Steven L. Carroll
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tyrosine Kinase ◽  
Differentially Expressed ◽  
Tyrosine Kinase Receptors ◽  
Adult Rat

Immunolocalization of the receptor tyrosine kinase EphA4 in the adult rat central nervous system

1997 ◽  
Vol 771 (2) ◽  
pp. 238-250 ◽  
Author(s):  
Maryann E Martone ◽  
Jocelyn A Holash ◽  
Angelica Bayardo ◽  
Elena B Pasquale ◽  
Mark H Ellisman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Adult Rat

Expression pattern of the ether-a-gogo-related (ERG) k+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system

2003 ◽  
Vol 466 (1) ◽  
pp. 119-135 ◽  
Author(s):  
Michele Papa ◽  
Francesca Boscia ◽  
Adriana Canitano ◽  
Pasqualina Castaldo ◽  
Stefania Sellitti ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Expression Pattern ◽  
K Channel ◽  
Adult Rat ◽  
Encoding Genes

Distribution of neurons expressing α1G subunit mRNA of T-type voltage-dependent calcium channel in adult rat central nervous system

1999 ◽  
Vol 268 (2) ◽  
pp. 77-80 ◽  
Author(s):  
Masahiko Kase ◽  
Shingo Kakimoto ◽  
Satoru Sakuma ◽  
Takeshi Houtani ◽  
Hitoshi Ohishi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Calcium Channel ◽  
Adult Rat ◽  
Subunit Mrna ◽  
Voltage Dependent Calcium Channel ◽  
Voltage Dependent

Myostatin expression in the adult rat central nervous system

2018 ◽  
Vol 94 ◽  
pp. 125-138 ◽  
Author(s):  
Yutaro Hayashi ◽  
Sumiko Mikawa ◽  
Chikara Ogawa ◽  
Kazuma Masumoto ◽  
Fuminori Katou ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adult Rat

BMP6 expression in the adult rat central nervous system

2019 ◽  
Vol 98 ◽  
pp. 41-54
Author(s):  
Yutaro Hayashi ◽  
Sumiko Mikawa ◽  
Chikara Ogawa ◽  
Kazuma Masumoto ◽  
Fuminori Katou ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adult Rat

Distribution of trkB tyrosine kinase immunoreactivity in the rat central nervous system

1993 ◽  
Vol 622 (1-2) ◽  
pp. 63-70 ◽  
Author(s):  
Xin-Fu Zhou ◽  
Luis F. Parada ◽  
Dan Soppet ◽  
Robert A. Rush
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tyrosine Kinase

scholarly journals Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Hannah N. Robeson ◽  
Hayley R. Lau ◽  
Laura A. New ◽  
Jasmin Lalonde ◽  
John N. Armstrong ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Olfactory Bulb ◽  
Adaptor Protein ◽  
Cell Types ◽  
Olfactory Nerve ◽  
Adult Brain ◽  
Specific Cell ◽  
Adult Rat ◽  
Fiber Tracts

Abstract Background Mammalian Shc (Src homology and collagen) proteins comprise a family of four phosphotyrosine adaptor molecules which exhibit varied spatiotemporal expression and signaling functions. ShcD is the most recently discovered homologue and it is highly expressed in the developing central nervous system (CNS) and adult brain. Presently however, its localization within specific cell types of mature neural structures has yet to be characterized. Results In the current study, we examine the expression profile of ShcD in the adult rat CNS using immunohistochemistry, and compare with those of the neuronally enriched ShcB and ShcC proteins. ShcD shows relatively widespread distribution in the adult brain and spinal cord, with prominent levels of staining throughout the olfactory bulb, as well as in sub-structures of the cerebellum and hippocampus, including the subgranular zone. Co-localization studies confirm the expression of ShcD in mature neurons and progenitor cells. ShcD immunoreactivity is primarily localized to axons and somata, consistent with the function of ShcD as a cytoplasmic adaptor. Regional differences in expression are observed among neural Shc proteins, with ShcC predominating in the hippocampus, cerebellum, and some fiber tracts. Interestingly, ShcD is uniquely expressed in the olfactory nerve layer and in glomeruli of the main olfactory bulb. Conclusions Together our findings suggest that ShcD may provide a distinct signaling contribution within the olfactory system, and that overlapping expression of ShcD with other Shc proteins may allow compensatory functions in the brain.

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