Evidence for estrogenic regulation of gonadotropin-releasing hormone neurons by glutamatergic neurons in the ewe brain: An immunohistochemical study using an antibody against vesicular glutamate transporter-2

2003 ◽  
Vol 465 (1) ◽  
pp. 136-144 ◽  
Author(s):  
Sueli Pompolo ◽  
Alda Pereira ◽  
Christopher James Scott ◽  
Fumino Fujiyma ◽  
Iain James Clarke
Keyword(s):  
Immunohistochemical Study ◽  
Glutamate Transporter ◽  
Gonadotropin Releasing Hormone ◽  
Vesicular Glutamate Transporter ◽  
Releasing Hormone ◽  
Glutamatergic Neurons ◽  
Estrogenic Regulation

scholarly journals Immunohistochemical Study on Gonadotropin-Releasing Hormone Neurons in the Shiba Goat Brain.

1992 ◽  
Vol 38 (2) ◽  
pp. 133-142 ◽  
Author(s):  
Tomohiro HAMADA ◽  
Takeo SHIMIZU ◽  
Masumi ICHIKAWA ◽  
Yuji MORI
Keyword(s):  
Immunohistochemical Study ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Goat Brain

scholarly journals The Existence of a Second Vesicular Glutamate Transporter Specifies Subpopulations of Glutamatergic Neurons

2001 ◽  
Vol 21 (22) ◽  
pp. RC181-RC181 ◽  
Author(s):  
Etienne Herzog ◽  
Gian Carlo Bellenchi ◽  
Christelle Gras ◽  
Véronique Bernard ◽  
Philippe Ravassard ◽  
...  
Keyword(s):  
Glutamate Transporter ◽  
Vesicular Glutamate Transporter ◽  
Glutamatergic Neurons

scholarly journals Hypophysiotropic Thyrotropin-Releasing Hormone and Corticotropin-Releasing Hormone Neurons of the Rat Contain Vesicular Glutamate Transporter-2

Endocrinology ◽  
2005 ◽  
Vol 146 (1) ◽  
pp. 341-347 ◽  
Author(s):  
Erik Hrabovszky ◽  
Gábor Wittmann ◽  
Gergely F. Turi ◽  
Zsolt Liposits ◽  
Csaba Fekete
Keyword(s):  
Glutamate Release ◽  
Glutamate Transporter ◽  
Microscopic Analysis ◽  
Male Rat ◽  
Confocal Laser ◽  
Vesicular Glutamate Transporter ◽  
Releasing Hormone ◽  
Large Numbers ◽  
Adult Male Rat ◽  
Dual Label

TRH and CRH are secreted into the hypophysial portal circulation by hypophysiotropic neurons located in parvicellular subdivisions of the hypothalamic paraventricular nucleus (PVH). Recently these anatomical compartments of the PVH have been shown to contain large numbers of glutamatergic neurons expressing type 2 vesicular glutamate transporter (VGLUT2). In this report we presented dual-label in situ hybridization evidence that the majority (>90%) of TRH and CRH neurons in the PVH of the adult male rat express the mRNA encoding VGLUT2. Dual-label immunofluorescent studies followed by confocal laser microscopic analysis of the median eminence also demonstrated the occurrence of VGLUT2 immunoreactivity within TRH and CRH axon varicosities, suggesting terminal glutamate release from these neuroendocrine systems. These data together indicate that the hypophysiotropic TRH and CRH neurons possess glutamatergic characteristics. Future studies will need to address the physiological significance of the endogenous glutamate content in these neurosecretory systems in the neuroendocrine regulation of thyroid and adrenal functions.

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