Analysis of the risk of malignancy associated with the basaloid and oncocytic subtypes of the salivary gland neoplasm of unknown malignant potential (SUMP) category in the Milan system

2021 ◽  
Author(s):  
Varsha Manucha ◽  
Maria F. Gonzalez ◽  
Israh Akhtar
Keyword(s):  
Salivary Gland ◽  
Malignant Potential ◽  
Salivary Gland Neoplasm ◽  
Risk Of Malignancy

scholarly journals Application of the Milan System for Reporting Salivary Gland Cytopathology: A Retrospective 12-Year Bi-institutional Study

2019 ◽  
Vol 151 (6) ◽  
pp. 613-621 ◽  
Author(s):  
Howard H Wu ◽  
Fatimah Alruwaii ◽  
Bao-Rung Zeng ◽  
Harvey M Cramer ◽  
Chiung-Ru Lai ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Benign Neoplasm ◽  
Malignant Potential ◽  
Salivary Gland Neoplasm ◽  
Uncertain Malignant Potential ◽  
Risk Of Malignancy ◽  
Predictive Rate ◽  
Sensitivity Specificity ◽  
Undetermined Significance

Abstract Objectives Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). Methods A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Risk of malignancy (ROM) for each category was calculated based on 694 histologic follow-up cases. Results The ROM for each category was: 18.3% for nondiagnostic, 8.9% for nonneoplastic, 37.5% for atypia of undetermined significance (AUS), 2.9% for benign neoplasm, 40.7% for salivary gland neoplasm of uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 98.3% for malignant. The sensitivity, specificity, positive predictive rate, and negative predictive rates were 89%, 99%, 98%, and 96%, respectively. Conclusions The results of the current study are in keeping with the MSRSGC. The indeterminate categories of AUS and SUMP showed intermediate ROMs at 37.5% and 40.7%, respectively.

Application of the Milan System for Reporting Salivary Gland Cytopathology: A 10-Year Experience in a Single Japanese Institution

2020 ◽  
pp. 1-9
Author(s):  
Yukiya Hirata ◽  
Kayoko Higuchi ◽  
Koichi Tamashiro ◽  
Keisuke Koja ◽  
Yuiko Yasutomi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Predictive Value ◽  
Diagnostic Category ◽  
Needle Aspiration ◽  
Salivary Gland Neoplasm ◽  
Published Evidence ◽  
Risk Of Malignancy ◽  
Categorization System ◽  
Sensitivity Specificity

<b><i>Objective:</i></b> The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a recently published evidence-based categorization system for salivary gland fine-needle aspiration (FNA). We applied MSRSGC to Japanese cases and evaluated its utility. <b><i>Study Design:</i></b> A total of 480 FNA cases were reviewed. We recategorized each case into one of the MSRSGC categories. The risk of neoplasm (RON) and the risk of malignancy (ROM) for each diagnostic category in MSRSGC, and the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) for malignancy and for neoplasms were calculated for cases with histological follow-up. In addition, the overall ROM (O-ROM) was calculated for all FNA cases. <b><i>Results:</i></b> RON, ROM, and O-ROM rates were as follows – non-diagnostic: 51.3, 5.1, and 1.0%; non-neoplastic: 0, 0, and 0%; atypia of undetermined significance: 83.9, 12.9, and 7.3%; neoplasm, benign: 100, 0, and 0%; salivary gland neoplasm of uncertain malignant potential: 100, 32.1, and 23.7%; suspicious for malignancy: 100, 85.7, and 60%; and malignant: 100, 100, 81.8%. The sensitivity, specificity, and accuracy with (without) indeterminate cases for malignancy were 65 (100), 99 (99), 92% (99%) and PPV and NPV were 96 and 100%, respectively, and those for neoplasms were 84 (100), 100 (100), 85% (100%), and PPV and NPV were 100 and 100%, respectively. <b><i>Conclusions:</i></b> The MSRSGC is useful for stratification of ROM and for promoting the performance of salivary gland FNA. The MSRSGC could be easily introduced in Japan and may improve the Japanese salivary gland FNA status.

scholarly journals Reporting Risk of Malignancy in Salivary Gland Cytopathology and Histopathology: A Cross-sectional Study

2021 ◽  
Author(s):  
Farah Jalaly Meenai ◽  
Naila Durrani ◽  
Swalaha Sadaf Siddique ◽  
Manal Ashraf Ali ◽  
Madhurima Singh
Keyword(s):  
Salivary Gland ◽  
Preoperative Evaluation ◽  
Needle Aspiration ◽  
Cross Sectional Study ◽  
Salivary Gland Neoplasm ◽  
Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Morphological Heterogeneity ◽  
Risk Of Malignancy

Introduction: For preoperative evaluation of patient with salivary gland lesion Fine Needle Aspiration Cytology (FNAC) is an effective technique, but due to lack of uniform system for reporting and also because of morphological heterogeneity and overlap between different lesions there are limitations, in its use. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was introduced which divides salivary gland lesions into six categories, guides in diagnosis and further management of Risk Of Malignancy (ROM) in different categories. Aim: The aim of the study was to classify salivary gland lesions according to MSRSGC and also evaluate for ROM in each category. Materials and Methods: This was a cross-sectional study looking at the data over a period of 3 years (2017 Jan to Dec 2019) in the Department of Pathology Chirayu Medical College and Hospital Bhopal. In this study salivary gland FNAC cases were categorised according to Milan System on cytopathology. Results: A total of 63 cases of salivary gland system FNAC were evaluated on cytology and classified according to MILAN system. Histopathological follow-up (correlation) was available in 47 cases. The risk of malignancy (ROM) in different categories was calculated. Category I Nondiagnostic constituted 25%, Category II Non-neoplastic comprised 0%, Category III Atypia of Undetermined Significance (AUS) showed 50% Category IV: (a) Benign showed 5.0% IV; (b) Salivary gland neoplasm of Uncertain Malignant Potential (SUMP) comprised 100%, Category V Suspicious for Malignancy (SM) comprised 100% and Category VI Malignant constituted 90%. Conclusion: MSRSGC is an evidence based effective system for salivary gland FNAC. It provides better communication with clinicians and improves over all patient care.

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