Fine needle aspiration of salivary gland carcinomas with high‐grade transformation: A multi‐institutional study of 22 cases and review of the literature

2020 ◽  
Author(s):  
Masato Nakaguro ◽  
William C. Faquin ◽  
Zubair W. Baloch ◽  
Richard L. Cantley ◽  
Margaret L. Compton ◽  
...  
CytoJournal ◽  
2010 ◽  
Vol 7 ◽  
pp. 18 ◽  
Author(s):  
Chetna N. Purohit ◽  
Marilyn M. Bui ◽  
Ardeshir Hakam

Osteoclast-rich undifferentiated carcinoma of urinary bladder (ORUCUB) is a very rare and an unusual variant of high-grade urothelial carcinoma. Here, we report an extraordinary case of metastatic ORUCUB, diagnosed by fine needle aspiration (FNA) biopsy, in a 74-year-old Hispanic male who presented with a palpable, tender left groin mass and a known previous history of high-grade carcinoma of urinary bladder and prostatic cancer. To the best of our knowledge, diagnosis of ORUCUB by FNA is the first case report in FNA cytology to be published to date. A review of the literature is emphasized on the cytological, histological and immunohistochemical features and differential diagnoses of giant cell tumor.


CytoJournal ◽  
2015 ◽  
Vol 12 ◽  
pp. 18 ◽  
Author(s):  
Sule Canberk ◽  
Mine Onenerk ◽  
Elif Sayman ◽  
Ceren Canbey Goret ◽  
Murat Erkan ◽  
...  

Introduction: DOG1 is a transmembrane protein originally “discovered on gastrointestinal stromal tumors,” works as a calcium-activated chloride channel protein. There is a limited number of studies on the potential usage of this antibody in the diagnosis of salivary gland tumors on routine practice in cell blocks. The aim of this study was to search for the usefulness of K9 clone in oncocytic type tumors and review of the literature. Materials and Methods: Sixty-nine fine needle aspiration (FNA) cytologic materials of predominantly oncocytic morphology salivary gland tumors; acinic cell carcinoma (AciCC) (n = 8), adenoid cystic carcinoma (n = 2), pleomorphic adenoma (PA) (n = 22), Warthin tumor (WT) (n = 20), myoepithelioma (ME) (n = 5), benign oncocytoma (BeO) (n = 3), mucoepidermoid carcinoma (MEC) (n = 7), mammary analog salivary gland carcinoma (n = 2) were immunostained with DOG1 (clone K9) stain. Results: Of the 8 AciCCs, 7 were observed apical-luminal positive staining, demonstrating 1–3 + intensity, and involving 40–70% of the tumor cells. One MEC of 7 (14%), 1 ME of 5 (20%), and 4 PA of 22 (18%) showed weak (1+) cytoplasmic granular staining in 5–10% of the tumor cells. Pure oncocytic neoplasms (WT, BeO) showed no expression with DOG1-K9. Conclusions: FNA is a common tool in the diagnosis and management of salivary gland tumors. DOG1-K9 clone was very useful with a unique staining pattern of apical-luminal positivity in the differential diagnosis of AciCC from other oncocytic salivary gland tumors.


2017 ◽  
Vol 45 (12) ◽  
pp. 1088-1094 ◽  
Author(s):  
He Wang ◽  
Aatika Malik ◽  
Zahra Maleki ◽  
Esther Diana Rossi ◽  
Bo Ping ◽  
...  

2013 ◽  
Vol 42 (11) ◽  
pp. 959-963 ◽  
Author(s):  
Mark A. Vande Haar ◽  
Denise DeFrias ◽  
Xiaoqi Lin

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