scholarly journals Distinguishing parathyroid and thyroid lesions on ultrasound‐guided fine‐needle aspiration: A correlation of clinical data, ancillary studies, and molecular analysis

2017 ◽  
Vol 125 (9) ◽  
pp. 674-682 ◽  
Author(s):  
Margaret Cho ◽  
Thaira Oweity ◽  
Tamar C. Brandler ◽  
Karen Fried ◽  
Pascale Levine
Keyword(s):  
Molecular Analysis ◽  
Clinical Data ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Ancillary Studies ◽  
Thyroid Lesions

Do anticoagulation medications increase the risk of haematoma in ultrasound-guided fine needle aspiration of thyroid lesions?

Cytopathology ◽  
2018 ◽  
Vol 29 (6) ◽  
pp. 565-568 ◽  
Author(s):  
Helmi Khadra ◽  
Roostam Kholmatov ◽  
Dominique Monlezun ◽  
Emad Kandil
Keyword(s):  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Thyroid Lesions

Manufactured Cell Blocks: Turning Smears into Sections

2019 ◽  
Vol 63 (1) ◽  
pp. 28-34
Author(s):  
Alexandra Kang ◽  
Alina Miranda ◽  
Bastiaan de Boer
Keyword(s):  
Lymph Node ◽  
Soft Tissue ◽  
Molecular Analysis ◽  
Fine Needle Aspiration ◽  
Retrospective Review ◽  
Needle Aspiration ◽  
Dna Integrity ◽  
Fine Needle ◽  
Molecular Studies ◽  
Ancillary Studies

Whilst cytological smears are still the basis of cytodiagnosis, there is an increasing role for ancillary testing. Specimens obtained are not always optimal, often with limited material for ancillary studies. Several reports have described the utility of scraping material from cytological smears to manufacture cell blocks to provide material for ancillary studies. Our objective was a retrospective review of the PathWest (QE2) experience with manufactured cell blocks (mCB) over the last 10 years. A total of 178 fine-needle aspiration cases with mCB were extracted from the PathWest database. Data were subdivided into: lymph node (89), breast (31), thyroid (23), soft tissue (13), liver (11), and other sites (11) and were analysed. All available material was reviewed. Diagnostic material was identified in 163 mCB (91.6%). Immunohistochemistry (IHC) was performed on 149 cases. Positive IHC staining was seen in 139 cases (93.3%) and advanced the diagnosis in 119 cases (79.9%). Molecular studies were performed on 38 mCB with adequate DNA obtained in 37 cases (97.3%). Our review has demonstrated that cellular material scraped from air-dried or prefixed smears can be made into cell blocks. Antigen preservation is adequate to provide diagnostically useful results with IHC whilst DNA integrity is preserved to allow molecular analysis.

scholarly journals Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience

CytoJournal ◽  
2016 ◽  
Vol 13 ◽  
pp. 1 ◽  
Author(s):  
Almed K. Alomari ◽  
Berrin Ustun ◽  
Harry R. Aslanian ◽  
Xinquan Ge ◽  
David Chhieng ◽  
...  
Keyword(s):  
Endoscopic Ultrasound ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Prior History ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Secondary Tumors ◽  
History Of ◽  
Ancillary Studies ◽  
Diagnostic Pitfalls

Background: Pancreatic masses may seldom represent a metastasis or secondary involvement by lymphoproliferative disorders. Recognition of this uncommon occurrence may help render an accurate diagnosis and avoid diagnostic pitfalls during endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). In this study, we review our experience in diagnosing secondary tumors involving the pancreas. Materials and Methods: The electronic database of cytopathology archives was searched for cases of secondary tumors involving the pancreas at our institution and a total of 31 cases were identified. The corresponding clinical presentations, imaging study findings, cytological diagnoses, the results of ancillary studies, and surgical follow-up, if available, were reviewed. Results: Nineteen of the patients were male and 12 female, with a mean age of 66 years. Twenty-three patients (74%) had a prior history of malignancy, with the latency ranging from 6 months to 19 years. The secondary tumors involving the pancreas included metastatic carcinoma (24 cases), metastatic sarcoma (3 cases), diffuse large B-cell lymphoma (2 cases), and plasma cell neoplasm (2 cases). The most common metastatic tumors were renal cell carcinoma (8 cases) and lung carcinoma (7 cases). Correct diagnoses were rendered in 29 cases (94%). The remaining two cases were misclassified as primary pancreatic carcinoma. In both cases, the patients had no known history of malignancy, and no ancillary studies were performed. Conclusions: Secondary tumors involving the pancreas can be accurately diagnosed by EUS-FNA. Recognizing uncommon cytomorphologic features, knowing prior history of malignancy, and performing ancillary studies are the keys to improve diagnostic performance and avoid diagnostic pitfalls.

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