Reliability of immunostaining using pan-melanoma cocktail, SOX10, and microphthalmia transcription factor in confirming a diagnosis of melanoma on fine-needle aspiration smears

2014 ◽  
Vol 122 (10) ◽  
pp. 779-785 ◽  
Author(s):  
Jessica Clevenger ◽  
Cicily Joseph ◽  
Marilyn Dawlett ◽  
Ming Guo ◽  
Yun Gong
Keyword(s):  
Transcription Factor ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Microphthalmia Transcription Factor

scholarly journals PAX8 is expressed in anaplastic thyroid carcinoma diagnosed by fine-needle aspiration: a study of three cases with histological correlates

2013 ◽  
Vol 169 (3) ◽  
pp. 307-311 ◽  
Author(s):  
Claudio Bellevicine ◽  
Antonino Iaccarino ◽  
Umberto Malapelle ◽  
Ferdinando Carlo Sasso ◽  
Bernardette Biondi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Anaplastic Thyroid Carcinoma ◽  
Fine Needle ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Two Samples ◽  
Design And Methods

ObjectiveIt is difficult to diagnose anaplastic thyroid carcinoma (ATC) in a fine-needle aspiration (FNA) sample because, given the loss of morphological and immunophenotypical follicular thyroid features, its cytology resembles that of other undifferentiated neoplasms. Recent studies have shown that immunostaining for paired box gene 8 (PAX8), a transcription factor expressed in normal thyroid, is effective for diagnosing ATCs on histology. The aim of this study was to evaluate whether PAX8 could be used to identify ATCs on cytology also.Design and methodsWe selected three PAX8-immunostained undifferentiated FNA samples previously diagnosed as suspected ATCs, whose cell block had been negative for the expression of TGB and thyroid transcription factor-1. Matched histological samples, available in two cases, were also processed for PAX8 immunohistochemistry.ResultsAll three FNA samples were PAX8 positive. Two samples that had an epithelioid pattern showed a diffuse, intense nuclear signal. The third sample, which had a spindle-cell pattern, showed less intense and more patchy staining. Matched histology yielded overlapping results.ConclusionsPAX8 immunocytochemistry can help cytopathologists to diagnose ATCs.

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