Performance of p16INK4a immunocytochemistry as a marker of anal squamous intraepithelial lesions

2011 ◽  
Vol 119 (3) ◽  
pp. 167-176 ◽  
Author(s):  
Ivan Tramujas da Costa e Silva ◽  
Michelle Coelho Ribeiro ◽  
Felicidad Santos Gimenez ◽  
Junia Raquel Dutra Ferreira ◽  
Renata Silva Galvao ◽  
...  
Keyword(s):  
Squamous Intraepithelial Lesions ◽  
Anal Squamous Intraepithelial Lesions ◽  
Intraepithelial Lesions

scholarly journals PD-1/PD-L1 expression in anal squamous intraepithelial lesions

Oncotarget ◽  
2020 ◽  
Vol 11 (39) ◽  
pp. 3582-3589
Author(s):  
Margot Bucau ◽  
Nathalie Gault ◽  
Nanthara Sritharan ◽  
Emy Valette ◽  
Charlotte Charpentier ◽  
...  
Keyword(s):  
Squamous Intraepithelial Lesions ◽  
Anal Squamous Intraepithelial Lesions ◽  
Intraepithelial Lesions

scholarly journals Human papillomavirus-associated anal squamous intraepithelial lesions in men who have sex with men and transgender women living with and without HIV in Karachi Pakistan: implications for screening and prevention

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Muslima Ejaz ◽  
Muhammad Mubarak ◽  
Tazeen Saeed Ali ◽  
Sören Andersson ◽  
Anna Mia Ekström
Keyword(s):  
Cox Regression ◽  
Transgender Women ◽  
Hiv Care ◽  
Low Grade ◽  
Squamous Intraepithelial Lesions ◽  
Transmitted Infection ◽  
Anal Cytology ◽  
Anal Squamous Intraepithelial Lesions ◽  
Sex With Men ◽  
Intraepithelial Lesions

Abstract Background Anal squamous intraepithelial lesions (ASIL), strongly related to human papilloma virus (HPV) infection, is more prevalent among men who have sex with men (MSM). However, no such data are available for Pakistan yet, and neither HPV vaccination nor anal-cytology screening is implemented in Pakistan. The purpose of this first ever study was to assess the prevalence of HPV-related anal cytological abnormalities among MSM and transgender women living with and without HIV infection in Pakistan. Methods We conducted a cross-sectional study from March 2016 to November 2017 at sexual health centers run by the Perwaaz Trust and the National AIDS Control Program in Karachi. The study enrolled MSM and transgender women aged greater-than-and-equal-to-18-years who reported anal sex in the preceding 6 months. We collected two anal samples for liquid-based cytology and HPV type testing by PCR, and socio-demographic and behavioral data were collected through face-to face interviews. ASIL and its associations with biological and behavioral risk factors were analyzed through Cox regression for prevalence ratios (PR) and corresponding 95% confidence intervals (CIs). Results Out of 271 qualifying participants, 79% were MSM and 21% transgender women. The mean age was 28.8 (± 8) years. Almost 35% (93/271) of the study population had ASIL detected, ASIL was significantly more common among participants living with HIV than in HIV negative ((50/118) 42.4%; vs. (43/153) 28.1%) (p ≤ 0.001). Among ASIL, 66% (61/93) had low-grade squamous intraepithelial lesions (LSIL), and 3.6% (3/93) had high-grade squamous intraepithelial lesions (HSIL). The overall, HPV16 positivity was 35.5% (33/93) among all abnormal anal lesions and all 3 HSIL were HPV16 positive, however, HPV16 positivity could show its association with ASIL detection in univariate model only (PRcrude: 2.11(1.39–3.18)). Moreover, any HR-HPV type (PR 3.04; 95% CI 1.75–5.26), concurrent sexually transmitted infection (STI) (2.13; (1.28–3.55)) and HIV + /HPV + coinfection (1.75; (1.07–2.88)) remained independently associated with ASIL in the multivariate model. Conclusions Abnormal anal cytology among MSM and transgender is prevalent enough to consider optimal screening regimens. Further studies are required to see if periodic anal cytology can be made part of HIV care and treatment programs among MSM in Pakistan.

Lack of regression of anal squamous intraepithelial lesions despite immune restoration under cART

AIDS ◽  
2013 ◽  
Vol 27 (3) ◽  
pp. 401-406 ◽  
Author(s):  
Christophe Piketty ◽  
Béatrice Cochand-Priollet ◽  
Emilie Lanoy ◽  
Ali Si-Mohamed ◽  
Selma Trabelsi ◽  
...  
Keyword(s):  
Squamous Intraepithelial Lesions ◽  
Immune Restoration ◽  
Anal Squamous Intraepithelial Lesions ◽  
Intraepithelial Lesions

Prevalence of anal squamous intraepithelial lesions in HIV-positive and HIV-negative men who have sex with men in Thailand.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 1598-1598
Author(s):  
T. Chalermchai ◽  
A. H. Li ◽  
J. Ananworanich ◽  
N. Teeratakulpisarn ◽  
W. Sathainthammawit ◽  
...  
Keyword(s):  
Hiv Positive ◽  
Squamous Intraepithelial Lesions ◽  
Anal Squamous Intraepithelial Lesions ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
Hiv Negative
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