scholarly journals Fine-needle aspiration cytopathology-An accurate diagnostic modality in mammary carcinoma with osteoclast-like giant cells

2010 ◽  
Vol 118 (6) ◽  
pp. 468-473 ◽  
Author(s):  
Solène-Florence Jacquet ◽  
Corinne Balleyguier ◽  
Jean-Rémi Garbay ◽  
Céline Bourgier ◽  
Marie-Christine Mathieu ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Mammary Carcinoma ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Diagnostic Modality ◽  
Fine Needle

Fine needle aspiration cytology of mammary carcinoma with osteoclast-like giant cells

Cytopathology ◽  
2004 ◽  
Vol 15 (6) ◽  
pp. 321-325 ◽  
Author(s):  
B. Vicandi ◽  
J. A. Jimenez-Heffernan ◽  
P. Lopez-Ferrer ◽  
D. Hardisson ◽  
A. Perez-Campos ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Mammary Carcinoma ◽  
Fine Needle Aspiration Cytology ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Aspiration Cytology of Pediatric Solitary Papillary Hyperplastic Thyroid Nodule

2001 ◽  
Vol 125 (12) ◽  
pp. 1575-1578 ◽  
Author(s):  
Kamal K. Khurana ◽  
Zubair W. Baloch ◽  
Virginia A. LiVolsi
Keyword(s):  
Fine Needle Aspiration ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Cytokeratin 19 ◽  
Intranuclear Inclusions ◽  
Cytologic Diagnosis ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
False Positive Diagnosis ◽  
Needle Aspiration Cytology

Abstract Context.—Solitary papillary hyperplastic thyroid nodules (SPHTNs) are frequently encountered in children and teenagers. Although the histologic features are well described, to the best of our knowledge, cytologic findings have not been reported. Objectives.—To review the cytologic features of histologically proven SPHTNs and to identify the potential diagnostic pitfalls in cytologic diagnosis. Materials and Methods.—Fine-needle aspiration cytology of 3 histologically proven SPHTNs was reviewed. Results.—Two girls and 1 boy (ages 11, 12, and 15 years) were affected. The cytologic diagnosis in all 3 cases was suspicious for papillary thyroid carcinoma (PTC). The spectrum of cytologic findings included broad flat sheets and 3-dimensional clusters with fire flares. There was mild to moderate nuclear pleomorphism and nuclear atypia. Short nonbranching papillae with transgressing vessels shown to represent hyperplastic papillae on histologic sections were identified in all cases. The background contained giant cells, histiocytes, and watery and inspissated colloid. Although nuclear grooves were identified in occasional cells, intranuclear inclusions were absent. A cell block section (1 case) and histologic sections of SPHTNs (2 cases) were immunohistochemically negative for cytokeratin 19. Conclusions.—Fine-needle aspiration of SPHTNs may be difficult to interpret accurately and can result in false-positive diagnosis of PTC. Although it shares several cytologic features with PTC, the presence of fire flares and short nonbranching papillae, as well as lack of intranuclear inclusions and watery and inspissated colloid in SPHTN appear to be useful features that are helpful in distinguishing SPHTN from PTC. Negative immunohistochemical staining for cytokeratin 19 is useful in excluding a diagnosis of PTC.

ROLE OF FINE NEEDLE ASPIRATION CYTOLOGY (FNAC) IN BONE TUMORS AND TUMOR LIKE LESIONS

2021 ◽  
pp. 69-70
Author(s):  
Ragini Kumari ◽  
Vikash M. Harinandan ◽  
Kunal Shankar ◽  
Ajit Kumar Chaudhary ◽  
Debarshi Jana
Keyword(s):  
Fine Needle Aspiration ◽  
Bone Tumors ◽  
Needle Aspiration ◽  
Bone Lesions ◽  
Diagnostic Modality ◽  
Predictive Values ◽  
Female Ratio ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background: FNAC is considered an important procedure in the diagnosis of bone tumors because of its high accuracy. In our study FNA was performed in patients to study the role of FNAC in the diagnosis of bone tumors and to evaluate its usefulness as a diagnostic modality. Methods: Fine needle aspiration was performed on 54 patients whose age ranged between 5 – 75 years with a male to female ratio 1.84 :1 presented with various bone lesions. The bone lesions included 42 (78%) primary lesions, 5 (9.3%) metastatic deposits and 7 (12. 7%) malignancy of related structures involving the bone. Results: 47 biopsy specimens were available for cytohistological correlation and cytological ndings of 45 cases correlated with histopathology. The overall diagnostic accuracy was 95.92%, with 100% sensitivity and specicity. The predictive values of positive as well as negative test were 100%. Conclusions:Thus FNAwas found to be a safe and an extremely useful, rapid method in the preliminary diagnosis of bone lesions.

Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up

2016 ◽  
Vol 60 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Lisa M. Rooper ◽  
Jeffrey S. Iding ◽  
Jonathan D. Cuda ◽  
Syed Z. Ali
Keyword(s):  
Differential Diagnosis ◽  
Fine Needle Aspiration ◽  
Mammary Carcinoma ◽  
Needle Aspiration ◽  
Partial Mastectomy ◽  
Low Grade ◽  
Fine Needle ◽  
Nuclear Atypia ◽  
Long Term Follow Up ◽  
Palpable Breast

Background: Fine-needle aspiration (FNA) is well-established as an accurate technique for the diagnosis of palpable breast masses. While the differential diagnosis of such lesions usually focuses on benign or malignant mammary proliferations, a subset of breast neoplasms arises from skin and soft tissue. Skin adnexal neoplasms such as hidradenoma can pose a particular pitfall on breast FNA cytology (FNAC) as epithelial proliferations that are not of ductal or lobular origin. Case: A 59-year-old female presented with a superficial breast mass. FNAC revealed a hypercellular lesion with marked nuclear atypia that was highly suspicious for carcinoma. However, at partial mastectomy, the histological features of the tumor were consistent with atypical hidradenoma. Negativity for estrogen receptor (ER) and progesterone receptor (PR) confirmed the diagnosis. Eighteen years later, the patient remains free of recurrence or metastasis. Conclusions: This report offers the first description of findings of atypical hidradenoma on FNAC. In the breast, its high cellularity and nuclear atypia can mimic a primary mammary carcinoma on FNAC. Although breast and skin adnexal tumors show a immunohistochemical overlap, negative ER and PR stains in a low-grade tumor can suggest a nonmammary lesion. Skin adnexal neoplasms should be considered in the differential diagnosis of superficial breast tumors.

scholarly journals SPOROTRIKOSIS LIMFOKUTAN DIAGNOSIS HISTOPATOLOGI DAN SITOLOGI

2013 ◽  
Vol 2 (1) ◽  
Author(s):  
Poppy M. Lintong ◽  
Inneke V. Sumolang
Keyword(s):  
Skin Lesion ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Histopathological Examination ◽  
Sporothrix Schenckii ◽  
Giant Cells ◽  
Skin Lesions ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Left Hand

Abstract: Diagnosis of sporotrichosis associated with lymphocutaneous nodules was made based on the histopathological examination of skin lesions and the cytology of fine needle aspiration biopsy (FNAB). A case of sporotrichosis in a 63-year-old man was reported with papules and nodules spread along the back of the left hand, forearm, and arm. The histopatho-logical examination showed infiltration of PMNs, granulomas, and giant cells in the dermis and epidermis, along with hyperplasia and microabscesses. Sporothrix schenckii was not found in the skin lesion tissues. However, in the FNAB cytology examination of lymphocutaneus nodules we found spores of Sporothrix schenckii in the cytoplasma of histiocytes besides granuloma and infiltration of PMNs. Key words: sporothrix schenckii, histopathology, FNAB cytology.  Abstrak: Diagnosis sporotrikosis kulit dengan nodul limfokutan ditegakkan melalui pemerik-saan histopatologi pada lesi kulit dan sitologi biopsi aspirasi jarum halus pada nodul limfo-kutan. Kami melaporkan kasus sporotrikosis pada laki-laki berusia 63 tahun dengan papul-papul dan nodul-nodul eritematosa pada dorsum manus, antebrakium, dan brakium sinistra. Pemeriksaan histopatologi jaringan biopsi dari lesi kulit menunjukkan reaksi radang, gambaran granuloma, dan sel datia dalam dermis dan epidermis, dengan mikroabses disertai hiperplasia. Tidak ditemukan jamur Sporothrix schenckii dalam potongan jaringan histopatologi. Hasil pemeriksaan sitologi biopsi aspirasi jarum halus pada nodul limfokutan memperlihatkan adanya spora-spora jamur Sporothrix schenckii dalam sitoplasma sel-sel histiosit disamping  terdapatnya bentuk granuloma dalam infiltrat radang. Kata kunci: sporothrix schenckii, histopatologi, sitologi biopsi aspirasi jarum halus.

Fine-Needle Aspiration Biopsy Features in a Case of Giant Cell Fibroblastoma of the Chest Wall

2001 ◽  
Vol 125 (8) ◽  
pp. 1091-1094
Author(s):  
Anirban Maitra ◽  
Charles F. Timmons ◽  
Momin T. Siddiqui ◽  
M. Hossein Saboorian
Keyword(s):  
Giant Cell ◽  
Chest Wall ◽  
Fine Needle Aspiration ◽  
Soft Tissues ◽  
Fine Needle Aspiration Biopsy ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Needle Aspiration Biopsy

Abstract Giant cell fibroblastoma is an unusual tumor of childhood, primarily occurring in the superficial soft tissues. We describe the fine-needle aspiration biopsy features of a case of giant cell fibroblastoma of the chest wall in a 3-year-old child. The aspirates comprised bland spindle to oval cells entrapped in a metachromatic matrix, accompanied by rare multinucleated giant cells with wreathlike nuclei. Although we were unable to render a definitive diagnosis on fine-needle aspiration biopsy, surgical resection of the mass established the diagnosis of giant cell fibroblastoma. We review the distinctive cytologic features of some common soft tissue tumors arising in this age group that may give rise to a diagnostic conundrum on fine-needle aspiration biopsy.

Fine-Needle Aspiration Cytology in the Diagnosis of Breast Paraffinoma

2021 ◽  
pp. 1-5
Author(s):  
Kenneth Y.Y. Kok ◽  
Pemasiri Upali Telisinghe ◽  
Sonal Tripathi
Keyword(s):  
Breast Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Diagnostic Procedures ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Multinucleated Giant Cells ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

<b><i>Introduction:</i></b> Paraffin injections for breast augmentation once a popular form of mammoplasty are now considered obsolete. It had been abandoned by clinicians because of its associated serious complications. The practice is however still available and is being practiced by nonmedically qualified people. Paraffin injection results in the formation of multiple foreign-body granulomas known as breast paraffinoma. The clinical features of breast paraffinoma can mimic and be mistaken for breast carcinoma or inflammatory breast carcinoma. The use of fine-needle aspiration cytology (FNAC) in the evaluation of patients with breast paraffinoma has not been fully evaluated. <b><i>Methods:</i></b> Retrospective review was performed on 30 patients who presented with breast paraffinoma between June 1, 2010, and June 30, 2020, who also had FNAC as part of their breast lump evaluation. <b><i>Results:</i></b> FNAC of 73.3% patients showed multinucleated giant cells and macrophages or histiocytes containing engulfed clear, empty intracytoplasmic vacuoles of varying sizes. In 13.3% of the patients, macrophages or histiocytes with engulfed clear intracytoplasmic vacuoles of varying sizes were seen. In 6.7% of patients, multinucleated giant cells containing engulfed vacuoles of varying sizes were seen, and in 6.7% of patients, hypocellular smears with large amount of clear spaces were seen. Oily droplets were seen in the background of all the smears, and there were no malignant cells seen. These features were compatible with breast paraffinoma. <b><i>Conclusion:</i></b> Most patients with breast paraffinoma can be managed conservatively and they do not require further treatment; FNAC with its characteristic features can provide the reliable diagnosis of breast paraffinoma and therefore sparing these patients from more invasive diagnostic procedures.

Sign in / Sign up

Export Citation Format

Share Document