Treatment patterns and outcomes of palliative systemic therapy in patients with salivary duct carcinoma and adenocarcinoma, not otherwise specified

Cancer ◽  
2021 ◽  
Author(s):  
Luana G. Sousa ◽  
Kaiwen Wang ◽  
Danice Torman ◽  
Bailee J. Binks ◽  
Maria Laura Rubin ◽  
...  
Keyword(s):  
Systemic Therapy ◽  
Treatment Patterns ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Not Otherwise Specified

Treatment patterns and systemic therapy outcomes for patients with salivary duct carcinoma and adenocarcinoma NOS.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 6084-6084
Author(s):  
Luana Guimarães Sousa ◽  
Kaiwen Wang ◽  
Danice Torman ◽  
Bailee Binks ◽  
Clark Andersen ◽  
...  
Keyword(s):  
Systemic Therapy ◽  
Locally Advanced ◽  
Treatment Patterns ◽  
Salivary Duct Carcinoma ◽  
Disease Stage ◽  
Her2 Overexpression ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Trimodality Therapy ◽  
Metastatic Setting

6084 Background: Salivary duct carcinoma (SDC) and adenocarcinoma, not otherwise specified (Adeno-NOS) are rare and aggressive subtypes of salivary gland cancers. Biomarker studies revealed targetable alterations such as androgen receptor (AR) and HER2 overexpression; nevertheless, chemotherapy (CT) remains the cornerstone treatment of patients (pts) with locally advanced or metastatic disease based on limited efficacy data. We sought to describe the treatment patterns and outcomes of SDC and Adeno-NOS pts. Methods: We retrospectively collected clinicopathological, treatment, and outcomes data of SDC or Adeno-NOS pts that were seen at MD Anderson from 1990-2020. AR positivity was defined by IHC staining in ≥ 10% of tumor cells, and HER2 by IHC 2+ or 3+ scores. Overall response rate (ORR) was assessed by an independent radiologist per RECIST v1.1. Recurrence-free survival (RFS) and overall survival (OS) from diagnosis were estimated using log-rank test. A multivariable cox regression model was performed to estimate the hazard-ratio (HR) of risk factors on pts outcomes. Results: 200 pts were included, 110 had SDC and 90 Adeno-NOS. Most pts (61%) presented with locoregional disease (stage III-IVB), while 13% had distant metastasis (IVC). AR was positive in 77% of cases, and HER2 in 47%. In the curative setting (N=174), 98% pts underwent surgery and 90% radiotherapy (RT); 15 pts with stage IVA-B disease had aggressive trimodality therapy including surgery, RT, and systemic therapy. Overall, 55% pts recurred. The mRFS and 5-y RFS rate were 24 mos (95%CI, 16-43) and 34.5%, respectively. For pts with IV-A-B stage, trimodality therapy was associated with an improved OS in comparison to surgery and/or RT (39 mos vs NA, p=0.04). In the metastatic setting, 82 pts received ≥1 line of systemic therapy; the preferred 1st line regimen was platinum/taxane with or without trastuzumab (50%). Table summarizes the ORR and mPFS to each therapy line. ORR and PFS was higher for HER2-targeted therapy (1st line: 47% and 11 mos; 2nd line 29% and 6 mos; respectively); only 10 pts received androgen blockage. At a median follow-up of 7.5 y, the mOS was 5 ys and the 5-y OS rate was 50%. In multivariate analysis, higher T and N stages (HR 2.1 and 3.8, p<0.05), and positive margins (HR 2.0, p=0.003) were associated with worse RFS; older age (HR 1.03, p=0.003), and higher TNM stage (HR 1.78, p=0.006) were associated with worse OS. HER2 expression was not prognostic. Conclusions: This study validates prognostic factors in SDC and adeno-NOS and is the largest series to report outcomes to palliative systemic therapy per treatment line, providing a benchmark for future studies in these diseases. Aggressive trimodality therapy may improve outcomes of pts with stage IVA-B disease.[Table: see text]

scholarly journals Systemic therapy in the management of recurrent or metastatic salivary duct carcinoma: A systematic review

2020 ◽  
Vol 89 ◽  
pp. 102069 ◽  
Author(s):  
M.J.M. Uijen ◽  
G. Lassche ◽  
A.C.H. van Engen-van Grunsven ◽  
Y. Tada ◽  
G.W. Verhaegh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Systemic Therapy ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma

“Adenocarcinoma, not otherwise Specified”: A Diminishing Group of Salivary Carcinomas

1992 ◽  
Vol 101 (1) ◽  
pp. 102-104 ◽  
Author(s):  
John G. Batsakis ◽  
Adel K. El-Naggar ◽  
Mario A. Luna
Keyword(s):  
Salivary Duct Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Not Otherwise Specified ◽  
Well Differentiated

As refinements in classification with clinicopathologic correlations proceed, the “adenocarcinomas, not otherwise specified” (NOS) of salivary tissue are reduced in number. Clinicopathologic entities such as salivary duct carcinoma, terminal duct carcinoma, and epimyoepithelial carcinoma, formerly in the NOS category, are examples of this process. There remain, however, adenocarcinomas of salivary tissues that cannot be accommodated in conventional classifications. They are the least common of salivary carcinomas and manifest a cytoarchitecture ranging from a well-differentiated, low-grade appearance to high-grade, invasive lesions. This report addresses this group of carcinomas for which the NOS designation is still applicable.

68-Gallium-PSMA-HBED-CC PET/CT imaging for recurrent/metastatic adenoid cystic carcinoma and salivary duct carcinoma

2019 ◽  
Author(s):  
W van Boxtel ◽  
S Lütje ◽  
AC van Engen-van Grunsven ◽  
GW Verhaegh ◽  
JA Schalken ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Ct Imaging ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Adenoid Cystic ◽  
Pet Ct

Salivary Duct Carcinoma with Unusual Clinical Course of Sialolithiasis

2014 ◽  
Vol 57 (4) ◽  
pp. 251
Author(s):  
Kyung Yeon Kim ◽  
Hae Sang Park ◽  
Sung Min Chung ◽  
Han Su Kim
Keyword(s):  
Clinical Course ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma

Analysis of PD-L1 expression in salivary duct carcinoma with its efficacy as a tumor marker

2019 ◽  
Vol 35 (1) ◽  
pp. 13-20
Author(s):  
Yong Ju Lee ◽  
Yoon Woo Koh ◽  
Sun Och Yoon ◽  
Hyang Joo Ryu ◽  
Hye Ryun Kim ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma

A lung tumor with features of salivary duct carcinoma

2021 ◽  
Author(s):  
Keisuke Sato ◽  
Mai Matsumura ◽  
Yoko Anzai ◽  
Hiromasa Arai ◽  
Motoki Sekiya ◽  
...  
Keyword(s):  
Lung Tumor ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma

The tumor immune contexture of salivary duct carcinoma

Head & Neck ◽  
2021 ◽  
Author(s):  
Gustavo Schvartsman ◽  
Diana Bell ◽  
Maria Laura Rubin ◽  
Michael Tetzlaff ◽  
Ehab Hanna ◽  
...  
Keyword(s):  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Immune Contexture
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