Fatigue and endocrine symptoms among women with early breast cancer randomized to endocrine versus chemoendocrine therapy: Results from the TAILORx patient‐reported outcomes substudy

Cancer ◽  
2021 ◽  
Author(s):  
Sofia F. Garcia ◽  
Robert J. Gray ◽  
Joseph A. Sparano ◽  
Amye J. Tevaarwerk ◽  
Ruth C. Carlos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Patient Reported Outcomes ◽  
Patient Reported ◽  
Chemoendocrine Therapy ◽  
Endocrine Symptoms

scholarly journals Patient-Reported Cognitive Impairment Among Women With Early Breast Cancer Randomly Assigned to Endocrine Therapy Alone Versus Chemoendocrine Therapy: Results From TAILORx

2020 ◽  
Vol 38 (17) ◽  
pp. 1875-1886 ◽  
Author(s):  
Lynne I. Wagner ◽  
Robert J. Gray ◽  
Joseph A. Sparano ◽  
Timothy J. Whelan ◽  
Sofia F. Garcia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Impairment ◽  
Adjuvant Chemotherapy ◽  
Endocrine Therapy ◽  
Early Breast Cancer ◽  
Menopausal Status ◽  
Unique Contribution ◽  
End Point ◽  
Patient Reported ◽  
Chemoendocrine Therapy

PURPOSE Cancer-related cognitive impairment (CRCI) is common during adjuvant chemotherapy and may persist. TAILORx provided a novel opportunity to prospectively assess patient-reported cognitive impairment among women with early breast cancer who were randomly assigned to chemoendocrine therapy (CT+E) versus endocrine therapy alone (E), allowing us to quantify the unique contribution of chemotherapy to CRCI. METHODS Women with a 21-gene recurrence score of 11 to 25 enrolled in TAILORX were randomly assigned to CT+E or E. Cognitive impairment was assessed among a subgroup of 552 evaluable women using the 37-item Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) questionnaire, administered at baseline, 3, 6, 12, 24, and 36 months. The FACT-Cog included the 20-item Perceived Cognitive Impairment (PCI) scale, our primary end point. Clinically meaningful changes were defined a priori and linear regression was used to model PCI scores on baseline PCI, treatment, and other factors. RESULTS FACT-Cog PCI scores were significantly lower, indicating more impairment, at 3, 6, 12, 24, and 36 months compared with baseline for both groups. The magnitude of PCI change scores was greater for CT+E than E at 3 months, the prespecified primary trial end point, and at 6 months, but not at 12, 24, and 36 months. Tests of an interaction between menopausal status and treatment were nonsignificant. CONCLUSION Adjuvant CT+E is associated with significantly greater CRCI compared with E at 3 and 6 months. These differences abated over time, with no significant differences observed at 12 months and beyond. These findings indicate that chemotherapy produces early, but not sustained, cognitive impairment relative to E, providing reassurance to patients and clinicians in whom adjuvant chemotherapy is indicated to reduce recurrence risk.

scholarly journals Are patient-reported outcomes useful in post-treatment follow-up care for women with early breast cancer? A scoping review

2019 ◽  
Vol Volume 10 ◽  
pp. 117-127 ◽  
Author(s):  
Cathrine Lundgaard Riis ◽  
Troels Bechmann ◽  
Pernille Tine Jensen ◽  
Angela Coulter ◽  
Karina Dahl Steffensen
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Scoping Review ◽  
Patient Reported Outcomes ◽  
Post Treatment ◽  
Patient Reported ◽  
Follow Up Care

scholarly journals Weight loss, physical and psychological patient reported outcomes (PROs) among obese patients (pts) with early breast cancer (BC)

2018 ◽  
Vol 29 ◽  
pp. viii621
Author(s):  
A. Di Meglio ◽  
M. El-Mouhebb ◽  
S. Michiels ◽  
L. Jones ◽  
E. Martin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Weight Loss ◽  
Early Breast Cancer ◽  
Patient Reported Outcomes ◽  
Obese Patients ◽  
Patient Reported

Exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy

2015 ◽  
Vol 5 (4) ◽  
pp. e275-e281 ◽  
Author(s):  
Ritu Arya ◽  
Sharareh Siamakpour-Reihani ◽  
Manisha Palta ◽  
Lisa Massa ◽  
Gloria Broadwater ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Early Breast Cancer ◽  
Patient Reported Outcomes ◽  
Exercise Behavior ◽  
Patient Reported

scholarly journals 90P Patient-reported outcomes among patients with HR+/HER2- early breast cancer: A systematic literature review

2020 ◽  
Vol 31 ◽  
pp. S45-S46
Author(s):  
E.M. Salvo ◽  
J. Cueto ◽  
E.H. Law ◽  
C. Aniceto Da Silva ◽  
C. Cameron ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Literature Review ◽  
Early Breast Cancer ◽  
Systematic Literature Review ◽  
Patient Reported Outcomes ◽  
Patient Reported
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