Weight loss does not decrease risk of breast cancer–related arm lymphedema

Cancer ◽  
2021 ◽  
Author(s):  
Sacha A. Roberts ◽  
Tessa C. Gillespie ◽  
Amy M. Shui ◽  
Cheryl L. Brunelle ◽  
Kayla M. Daniell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Weight Loss ◽  
Arm Lymphedema

scholarly journals Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kayo Togawa ◽  
Huiyan Ma ◽  
Ashley Wilder Smith ◽  
Marian L. Neuhouser ◽  
Stephanie M. George ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Physical Health ◽  
Analysis Of Covariance ◽  
Health Related Quality ◽  
Burning Pain ◽  
Related Quality ◽  
Health Related ◽  
Arm Lymphedema

AbstractWe examined cross-sectional associations between arm lymphedema symptoms and health-related quality of life (HRQoL) in the Health, Eating, Activity and Lifestyle (HEAL) Study. 499 women diagnosed with localized or regional breast cancer at ages 35–64 years completed a survey, on average 40 months after diagnosis, querying presence of lymphedema, nine lymphedema-related symptoms, e.g., tension, burning pain, mobility loss, and warmth/redness, and HRQoL. Analysis of covariance models were used to assess HRQoL scores in relation to presence of lymphedema and lymphedema-related symptoms. Lymphedema was self-reported by 137 women, of whom 98 were experiencing lymphedema at the time of the assessment. The most common symptoms were heaviness (52%), numbness (47%), and tightness (45%). Perceived physical health was worse for women reporting past or current lymphedema than those reporting no lymphedema (P-value < 0.0001). No difference was observed for perceived mental health (P-value = 0.31). Perceived physical health, stress, and lymphedema-specific HRQoL scores worsened as number of symptoms increased (P-values ≤ 0.01). Women reporting tension in the arm had lower physical health (P-value = 0.01), and those experiencing burning pain, tension, heaviness, or warmth/redness in the arm had lower lymphedema-specific HRQoL (P-values < 0.05). Treatment targeting specific lymphedema-related symptoms in addition to size/volume reduction may improve some aspects of HRQoL among affected women.

scholarly journals Reduced-Calorie Dietary Weight Loss, Exercise, and Sex Hormones in Postmenopausal Women: Randomized Controlled Trial

2012 ◽  
Vol 30 (19) ◽  
pp. 2314-2326 ◽  
Author(s):  
Kristin L. Campbell ◽  
Karen E. Foster-Schubert ◽  
Catherine M. Alfano ◽  
Chia-Chi Wang ◽  
Ching-Yun Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Free Testosterone ◽  
Randomized Controlled ◽  
Weight Loss Diet ◽  
Vigorous Intensity ◽  
Free Estradiol

Purpose Estrogens and androgens are elevated in obesity and associated with increased postmenopausal breast cancer risk, but the effect of weight loss on these biomarkers is unknown. We evaluated the individual and combined effects of a reduced-calorie weight loss diet and exercise on serum sex hormones in overweight and obese postmenopausal women. Patients and Methods We conducted a single-blind, 12-month, randomized controlled trial from 2005 to 2009. Participants (age 50 to 75 years; body mass index > 25.0 kg/m2, exercising < 100 minutes/wk) were randomly assigned using a computer-generated sequence to (1) reduced-calorie weight loss diet (“diet”; n = 118), (2) moderate- to vigorous-intensity aerobic exercise (“exercise”; n = 117), (3) combined reduced-calorie weight loss diet and moderate- to vigorous-intensity aerobic exercise (“diet + exercise”; n = 117), or (4) control (n = 87). Outcomes were estrone concentration (primary) and estradiol, free estradiol, total testosterone, free testosterone, androstenedione, and sex hormone–binding globulin (SHBG) concentrations (secondary). Results Mean age and body mass index were 58 years and 30.9 kg/m2, respectively. Compared with controls, estrone decreased 9.6% (P = .001) with diet, 5.5% (P = .01) with exercise, and 11.1% (P < .001) with diet + exercise. Estradiol decreased 16.2% (P < .001) with diet, 4.9% (P = .10) with exercise, and 20.3% (P < .001) with diet + exercise. SHBG increased 22.4% (P < .001) with diet and 25.8% (P < .001) with diet + exercise. Free estradiol decreased 21.4% (P < .001) with diet and 26.0% (P < .001) with diet + exercise. Free testosterone decreased 10.0% (P < .001) with diet and 15.6% (P < .001) with diet + exercise. Greater weight loss produced stronger effects on estrogens and SHBG. Conclusion Weight loss significantly lowered serum estrogens and free testosterone, supporting weight loss for risk reduction through lowering exposure to breast cancer biomarkers.

Breast cancer survivors’ experience of making weight, dietary and physical activity changes during participation in a weight loss intervention

2016 ◽  
Vol 25 (5) ◽  
pp. 1455-1463 ◽  
Author(s):  
Caroline O Terranova ◽  
Sheleigh P Lawler ◽  
Kym Spathonis ◽  
Elizabeth G Eakin ◽  
Marina M Reeves
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Weight Loss ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Weight Loss Intervention

scholarly journals Height, weight, weight change and risk of breast cancer in Rio de Janeiro, Brazil

2001 ◽  
Vol 119 (2) ◽  
pp. 62-66 ◽  
Author(s):  
Anelise Bezerra de Vasconcelos ◽  
Gulnar Azevedo e Silva Mendonça ◽  
Rosely Sichieri
Keyword(s):  
Breast Cancer ◽  
Weight Loss ◽  
Rio De Janeiro ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Positive Association ◽  
State University ◽  
Weight Changes ◽  
Potential Risk Factors ◽  
Incident Cases

CONTEXT: The relationship between body size and breast cancer still remains controversial in considering menopausal status. OBJECTIVE: To evaluate the association of height, weight and weight changes with breast cancer in the city of Rio de Janeiro, Brazil. DESIGN: Case-control study. SETTING: National Cancer Institute (INCA), Rio de Janeiro, Brazil, and State University of Rio de Janeiro (UERJ). SAMPLE: 177 incident cases of invasive breast cancer admitted to the main hospital of INCA between May 1995 and February 1996, and 377 controls recruited from among female visitors to the same hospital. MAIN MEASUREMENTS: Height and weight were measured and information on maximum weight, weight at ages 18 and 30 years, and potential risk factors were ascertained by interview at the hospital. RESULTS: Height was not related to risk of breast cancer among both pre and postmenopausal women. Nevertheless, women in this study were shorter than in studies that have found a positive association. Premenopausal women in the upper quartile of recent body mass index (BMI) and maximum BMI showed a reduced risk of breast cancer (P for trend <= 0.03). Weight loss between ages 18 and 30 years and from 18 years to present was also associated with breast cancer among premenopausal women. CONCLUSIONS: These findings may merely indicate the known association between leanness and breast cancer. Further studies should explore the role of weight loss on breast cancer risk.

scholarly journals Liposuction of Breast Cancer-Related Arm Lymphedema Reduces Fat and Muscle Hypertrophy

2021 ◽  
Author(s):  
Tobias Karlsson ◽  
Magnus Karlsson ◽  
Karin Ohlin ◽  
Gaby Olsson ◽  
Håkan Brorson
Keyword(s):  
Breast Cancer ◽  
Muscle Hypertrophy ◽  
Arm Lymphedema

scholarly journals Weight loss, diet composition and breast cancer incidence and outcome in postmenopausal women

Oncotarget ◽  
2019 ◽  
Vol 10 (33) ◽  
pp. 3088-3092 ◽  
Author(s):  
Kathy Pan ◽  
Juhua Luo ◽  
Aaron K. Aragaki ◽  
Rowan T. Chlebowski
Keyword(s):  
Breast Cancer ◽  
Weight Loss ◽  
Postmenopausal Women ◽  
Cancer Incidence ◽  
Diet Composition ◽  
Breast Cancer Incidence ◽  
Weight Loss Diet
Sign in / Sign up

Export Citation Format

Share Document