scholarly journals Time‐varying survival effects for squamous cell carcinomas at oropharyngeal and nonoropharyngeal head and neck sites in the United States, 1973‐2015

Cancer ◽  
2020 ◽  
Vol 126 (23) ◽  
pp. 5137-5146
Author(s):  
Andrew F. Brouwer ◽  
Kevin He ◽  
Steven B. Chinn ◽  
Alison M. Mondul ◽  
Christina H. Chapman ◽  
...  
Keyword(s):  
United States ◽  
Head And Neck ◽  
Squamous Cell ◽  
The United States ◽  
Squamous Cell Carcinomas ◽  
Time Varying

All-Cause 30-Day Mortality After Surgical Treatment for Head and Neck Squamous Cell Carcinoma in the United States

2019 ◽  
Vol 42 (7) ◽  
pp. 596-601 ◽  
Author(s):  
Aleksandr R. Bukatko ◽  
Parth B. Patel ◽  
Vindhya Kakarla ◽  
Matthew C. Simpson ◽  
Eric Adjei Boakye ◽  
...  
Keyword(s):  
United States ◽  
Squamous Cell Carcinoma ◽  
Surgical Treatment ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
The United States ◽  
Neck Squamous Cell Carcinoma

scholarly journals PCN51 ECONOMIC BURDEN OF SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK (SCCHN) IN THE UNITED STATES

2019 ◽  
Vol 22 ◽  
pp. S65
Author(s):  
A. Berger ◽  
M. Contente ◽  
N. Kumar ◽  
P. Abraham ◽  
R. Shah ◽  
...  
Keyword(s):  
United States ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Economic Burden ◽  
The United States

Changes in the proportion of squamous cell carcinoma in head and neck cancer in the United States and Canada, 1995-2015.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17554-e17554
Author(s):  
Matthew Gaubatz ◽  
Aleksandr R Bukatko ◽  
Katherine M. Polednik ◽  
Matthew C Simpson ◽  
Eric Adjei Boakye ◽  
...  
Keyword(s):  
United States ◽  
Squamous Cell Carcinoma ◽  
Head And Neck Cancer ◽  
North America ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
The United States ◽  
Apparent Lack

e17554 Background: There has been a shift in the epidemiologic landscape of head and neck cancer (HNC) with decreasing incidence of tobacco-related and increasing incidence of human papillomavirus (HPV)-related HNC. While it is often reported that ≥ 90% of HNC is considered squamous cell carcinoma (SCC), there is an apparent lack of recent population-based data to support this claim. This study aimed to estimate the current proportion and evaluate change in the proportion of SCC in HNC diagnoses in North America (United States and Canada) from 1995 to 2015. Methods: We queried the North American Association of Central Cancer Registries (NAACCR) database for HNC cases that were of either squamous (SQ) (ICD-0-3: 8050-8089) or squamous plus unspecified epithelial (SQE) (ICD-0-3:8010-8089) origin in the United States and Canada ( n = 1,054,409). All HNC included in the analysis were microscopically confirmed, malignant head and neck primary tumor sites of the oral cavity, nasopharynx, hypopharynx, oropharynx, nasal cavity, and larynx. Sub-analyses were conducted across more extensive cohort restriction combinations (country specific, registry specific, and primary sequence of cancer). Results: The overall proportion of SCC in HNC in North America from 1995-2015 was 81.7% (95% CI: 81.7 – 81.8) for SQ and 84.9% (95% CI: 84.8 – 85.0) for SQE. The proportion of SCC in HNC peaked in 2015 with 83.3% (95% CI: 83.0 – 83.6) for SQ and 85.9% (95% CI: 85.6 – 86.2) for SQE; and was lowest in 2005 with 80.7% (95% CI: 80.4 – 81.1) for SQ and 84.3% (95% CI: 83.9 – 84.6) for SQE. In the time period of this study (1995 – 2015), there were no years for which SQ or SQE made up 90% or more of HNC for any of the HNC cohorts. Conclusions: The changing landscape of HNC risk factors in the United States and Canada warrants re-evaluation and update of HNC epidemiological literature with regards to the proportion of SCC in HNC.

scholarly journals Vaccine Strategies for Human Papillomavirus-Associated Head and Neck Cancers

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 33
Author(s):  
Jade Z. Zhou ◽  
Jessica Jou ◽  
Ezra Cohen
Keyword(s):  
United States ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Squamous Cell ◽  
The United States ◽  
Oral Infection ◽  
Hpv Vaccines ◽  
Global Epidemiology ◽  
Rising Incidence ◽  
Hpv 18

The rising incidence of oropharyngeal squamous cell cancers (OPSCC) in the United States is largely attributed to HPV. Prophylactic HPV vaccines have demonstrated effectiveness against oral infection of HPV 16 and HPV 18. We review the global epidemiology and biology of HPV-related cancers as well as the development of HPV vaccines and their use worldwide. We also review the various strategies and challenges in development of therapeutic HPV vaccines.

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