scholarly journals Extracapsular extension of neck nodes and absence of human papillomavirus 16‐DNA are predictors of impaired survival in p16‐positive oropharyngeal squamous cell carcinoma

Cancer ◽  
2020 ◽  
Vol 126 (9) ◽  
pp. 1856-1872 ◽  
Author(s):  
Josefine Freitag ◽  
Theresa Wald ◽  
Thomas Kuhnt ◽  
Tanja Gradistanac ◽  
Marlen Kolb ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Extracapsular Extension ◽  
Human Papillomavirus 16

Machine Learning Prediction of Extracapsular Extension in Human Papillomavirus–Associated Oropharyngeal Squamous Cell Carcinoma

2020 ◽  
Vol 163 (5) ◽  
pp. 992-999
Author(s):  
Kyle M. Hatten ◽  
Julian Amin ◽  
Amal Isaiah
Keyword(s):  
Machine Learning ◽  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Conditional Inference ◽  
National Cancer Database ◽  
Extracapsular Extension

Objective To determine whether machine learning (ML) can predict the presence of extracapsular extension (ECE) prior to treatment, using common oncologic variables, in patients with human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC). Study Design Retrospective database review. Setting National Cancer Database study. Methods All patients with HPV-associated OPSCC treated surgically between January 1, 2010, and December 31, 2015, were selected from the National Cancer Database. Patients were excluded if surgical pathology reports did not include information regarding primary tumor stage, number of metastatic regional lymph nodes, size of largest metastatic regional lymph node, and tumor grade. The data were split into a random distribution of 80% for training and 20% for testing with ML methods. Results A total of 3753 adults with surgically treated HPV-associated OPSCC met criteria for inclusion in the study. Approximately 38% of these patients treated with surgical management demonstrated ECE. ML models demonstrated modest accuracy in predicting ECE, with the areas under the receiver operating characteristic curves ranging from 0.58 to 0.68. The conditional inference tree model (0.66) predicted the metastatic lymph node number to be the most important predictor of ECE. Conclusion Despite a large cohort and the use of ML algorithms, the power of clinical and oncologic variables to predict ECE in HPV-associated OPSCC remains limited.

Transoral robotic surgery for oropharyngeal squamous cell carcinoma in the era of human papillomavirus

Head & Neck ◽  
2017 ◽  
Vol 40 (4) ◽  
pp. 710-721 ◽  
Author(s):  
Omar Mahmoud ◽  
Kim Sung ◽  
Francisco J. Civantos ◽  
Giovanna R. Thomas ◽  
Michael A. Samuels
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Robotic Surgery ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transoral Robotic Surgery ◽  
Oropharyngeal Squamous Cell Carcinoma
Sign in / Sign up

Export Citation Format

Share Document