scholarly journals Dose‐dependent effect of aerobic exercise on inflammatory biomarkers in a randomized controlled trial of women at high risk of breast cancer

Cancer ◽  
2019 ◽  
Vol 126 (2) ◽  
pp. 329-336 ◽  
Author(s):  
Jeremy S. Haley ◽  
Elizabeth A. Hibler ◽  
Shouhao Zhou ◽  
Kathryn H. Schmitz ◽  
Kathleen M. Sturgeon
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
High Risk ◽  
Aerobic Exercise ◽  
Controlled Trial ◽  
Inflammatory Biomarkers ◽  
Dependent Effect ◽  
Randomized Controlled ◽  
Dose Dependent ◽  
Dose Dependent Effect

scholarly journals Dose–response effects of aerobic exercise on estrogen among women at high risk for breast cancer: a randomized controlled trial

2015 ◽  
Vol 154 (2) ◽  
pp. 309-318 ◽  
Author(s):  
Kathryn H. Schmitz ◽  
Nancy I. Williams ◽  
Despina Kontos ◽  
Susan Domchek ◽  
Knashawn H. Morales ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
High Risk ◽  
Aerobic Exercise ◽  
Dose Response ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals The Effects of Exercise Duration and Intensity on Breast Cancer-Related DNA Methylation: A Randomized Controlled Trial

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4128
Author(s):  
Arielle S. Gillman ◽  
Timothy Helmuth ◽  
Claire E. Koljack ◽  
Kent E. Hutchison ◽  
Wendy M. Kohrt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Randomized Controlled Trial ◽  
Aerobic Exercise ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Post Intervention ◽  
Randomized Controlled ◽  
Supervised Exercise

Emerging research suggests that one mechanism through which physical activity may decrease cancer risk is through its influence on the methylation of genes associated with cancer. The purpose of the current study was to prospectively test, using a rigorous experimental design, whether aerobic exercise affects DNA methylation in genes associated with breast cancer, as well as whether quantity of exercise completed affects change in DNA methylation in a dose–response manner. 276 women (M age = 37.25, SD = 4.64) were recruited from the Denver metro area for a randomized controlled trial in which participants were assigned to a supervised aerobic exercise program varying in a fully crossed design by intensity (55–65% versus 75–85% of VO2max) and duration (40 versus 20 min per session). DNA methylation was assessed via blood samples provided at baseline, after completing a 16-week supervised exercise intervention, and six months after the intervention. 137 participants completed the intervention, and 81 had viable pre-post methylation data. Contrary to our hypotheses, total exercise volume completed in kcal/kg/week was not associated with methylation from baseline to post-intervention for any of the genes of interest. An increase in VO2max over the course of the intervention, however, was associated with decreased post-intervention methylation of BRCA1, p = 0.01. Higher levels of self-reported exercise during the follow-up period were associated with lower levels of GALNT9 methylation at the six-month follow-up. This study provides hypothesis-generating evidence that increased exercise behavior and or increased fitness might affect methylation of some genes associated with breast cancer to reduce risk.

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