scholarly journals Severity of reduced bone mineral density and risk of fractures in long‐term survivors of childhood leukemia and lymphoma undergoing guideline‐recommended surveillance for bone health

Cancer ◽  
2019 ◽  
Vol 126 (1) ◽  
pp. 202-210
Author(s):  
Hadley M. Bloomhardt ◽  
Kyaw Sint ◽  
Wilhelmenia L. Ross ◽  
Jaime Rotatori ◽  
Kathryn Ness ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
Childhood Leukemia ◽  
Mineral Density ◽  
Long Term Survivors

Bone mineral density, body composition, and height in long-term survivors of acute lymphoblastic leukemia in childhood

2000 ◽  
Vol 35 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Inge M. van der Sluis ◽  
Marry M. van den Heuvel-Eibrink ◽  
Karel H�hlen ◽  
Eric P. Krenning ◽  
Sabine M.P.F. de Muinck Keizer-Schrama
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Acute Lymphoblastic Leukemia ◽  
Bone Mineral ◽  
Lymphoblastic Leukemia ◽  
Mineral Density ◽  
Long Term Survivors

Bone Mineral Density of Very Long-term Survivors After Childhood Liver Transplantation

2018 ◽  
Vol 66 (5) ◽  
pp. 797-801
Author(s):  
Looi C. Ee ◽  
Charlton Noble ◽  
Jonathan Fawcett ◽  
Geoffrey J. Cleghorn
Keyword(s):  
Bone Mineral Density ◽  
Liver Transplantation ◽  
Bone Mineral ◽  
Mineral Density ◽  
Long Term Survivors

Bone mineral density in long-term survivors of highly malignant osteosarcoma

2003 ◽  
Vol 85-B (2) ◽  
pp. 231-237 ◽  
Author(s):  
G. Holzer ◽  
P. Krepler ◽  
M. A. Koschat ◽  
S. Grampp ◽  
M. Dominkus ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Long Term Survivors

scholarly journals Bone mineral density is compromised in very long-term survivors of irradiated childhood brain tumor

2018 ◽  
Vol 57 (5) ◽  
pp. 665-674 ◽  
Author(s):  
Tiina M. Remes ◽  
Pekka M. Arikoski ◽  
Päivi M. Lähteenmäki ◽  
Mikko O. Arola ◽  
Tytti M.-L. Pokka ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Brain Tumor ◽  
Bone Mineral ◽  
Childhood Brain Tumor ◽  
Mineral Density ◽  
Long Term Survivors

Bone Density Measurements in Patients with Severe Chronic Neutropenia On Long-Term G-CSF Therapy.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 1362-1362 ◽  
Author(s):  
David C. Dale ◽  
Audrey Anna Bolyard ◽  
Linda A DiMeglio ◽  
Tracy M Marrero ◽  
Laurence A. Boxer
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
Median Dose ◽  
Mineral Density ◽  
Cyclic Neutropenia ◽  
Density Measurements ◽  
Day Range ◽  
Chronic Neutropenia

Abstract Abstract 1362 G-CSF is a very effective treatment for idiopathic, congenital and cyclic neutropenia (SCN). G-CSF also expands myeloid tissues that give rise to osteoclasts that resorb bone. For this reason, the Severe Chronic Neutropenia International Registry (SCNIR) has collected data on fractures in this population for over 15 years. These data indicate that fractures are uncommon events. To expand information on bone health for patients on long-term G-CSF, we collected additional information from a patient survey and reviewed reports of bone mineral density measurements (BMD) in US children and adults in the SCNIR. Letters were sent to 680 patients; 367 responded. 17 of 367 patients reported fractures; 15 were related to accidents (11 extremities, 4 spine) and 2 were categorized as spontaneous (both spine). The frequency of fractures was 0.005 per patient year on G-CSF. 222 patients indicated that they had not had a BMD study. We received 266 BMDs on 145 subjects (45 children {<21 years of age} and 100 adults) having sufficient information in a standard report format for evaluation. There were 82 BMDs in the 45 children and 184 BMDs in the 100 adults. For adults, abnormal BMD was defined as a t score less than -2.5; for children abnormal was a z score of less than -2.0. 205 of 266 BMD reports were normal; BMDs for 34 of 45 children and 85 of 100 adults were normal. 11 BMDs prior to G-CSF treatment were normal (4 children, 5 adults – 2 adults had 2 normal BMDs) and 194 BMDs during G-CSF treatment were normal (30 children, 85 adults). The G-CSF median dose for children with normal scans was 5.1 mcg/kg/day (range 0.0 - 53) and for adults was 1.1 mcg/kg/day (range 0.0 - 38). 61 of 266 scans were abnormal in 11 children and 15 adults. 1 of 6 adult scans prior to G-CSF treatment was abnormal. During G-CSF treatment there were 60 abnormal BMDs in 11 children and 14 adults. The G-CSF median dose for children with abnormal BMDs was 3.6 mcg/kg/day (range 0.0 - 18) and for adults was 2.3 mcg/kg/day (range 0.0 - 37). 28 subjects (8 children, 20 adults) had three or more sequential BMD reports. Of these, 17 subjects (3 children, 14 adults) suggested a trend of decreasing BMD while on G-CSF, 11 subjects (5 children, 6 adults) had normal serial BMDs on G-CSF without trending toward decreased bone mineral density. 33 patients reported treatments with osteoporosis medications; 15(46%) calcium supplements, 12(36%) bisphosphonates, 3(9%) Vitamin D supplements, 2(6%) hormonal supplements, and 1(3%) calcitonin; the effectiveness of these therapies could not be evaluated. This survey confirms that overt fractures are low-frequency events for patients with SCN on many years of G-CSF therapy. The trend toward decreased BMD in approximately 60% of patients with serial assessments suggests that bone loss is a common effect of chronic G-CSF treatment. The data also suggest that baseline and follow-up BMD assessments are useful for determining bone health for SCN patients on long term G-CSF therapy. Disclosures Dale: Amgen Inc.: Consultancy, Honoraria, Research Funding, Speaker. Boxer:Amgen Inc.: Equity Ownership.

scholarly journals The Relationship between Parity and Bone Mineral Density in Women Characterized by a Homogeneous Lifestyle and High Parity

2005 ◽  
Vol 90 (8) ◽  
pp. 4536-4541 ◽  
Author(s):  
Elizabeth A. Streeten ◽  
Kathleen A. Ryan ◽  
Daniel J. McBride ◽  
Toni I. Pollin ◽  
Alan R. Shuldiner ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Health ◽  
Long Term Effects ◽  
Mineral Density ◽  
High Parity ◽  
Hip Bmd ◽  
Caucasian Women ◽  
Few Data

Abstract Context: We reported previously that Old Order Amish (OOA) women have fewer hip fractures and higher bone mineral density (BMD) than non-Amish Caucasian women. Objective: The objective of this study was to determine whether the high parity characteristic of OOA women contributes to their relative bone health. Previous data on the long-term effects of parity on BMD have yielded conflicting results with few data from very high parity populations. This observational study included participants in the Amish Family Osteoporosis Study, begun in 1997 to identify genetic and clinical determinants of osteoporosis in the OOA. We measured BMD by dual-energy x-ray absorptiometry at the spine, hip, and distal radius in 424 parous OOA women aged 40 and older (mean age, 57.7 ± 12 yr; mean parity, 7.6 ± 2.9). Results: Increasing parity was associated with later menopause (P = 0.001) and modestly, but not significantly, higher body mass index (BMI) (P = 0.09). Increasing parity was associated with higher BMD at the total hip and trochanter (age-adjusted P = 0.02 and 0.03), no longer statistically significant after accounting for BMI. Among women aged 50–59 yr, parity was strongly associated with BMD even after accounting for age and BMI (age-adjusted P = 0.02), although this was not true for women younger than 50 or at least 60 yr old. Conclusions: We conclude that high parity is associated with increased hip BMD in OOA women, largely mediated by higher BMI. The parity-hip BMD association remained statistically significant after accounting for age and BMI only in women aged 50–59 yr, partially explained by a later menopausal age with high parity. The benefit of high parity on BMD appeared to be lost soon after the menopausal transition, and, therefore, these data provide evidence of neither a detrimental nor beneficial effect of high parity on long-term bone health.

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