scholarly journals Improvement in sexual function after ovarian cancer: Effects of sexual therapy and rehabilitation after treatment for ovarian cancer

Cancer ◽  
2017 ◽  
Vol 124 (1) ◽  
pp. 176-182 ◽  
Author(s):  
Sharon L. Bober ◽  
Christopher J. Recklitis ◽  
Alexis L. Michaud ◽  
Alexi A. Wright
Keyword(s):  
Ovarian Cancer ◽  
Sexual Function ◽  
Sexual Therapy

LION-PAW (lymphadenectomy in ovarian neoplasm) sexual function assessment: a prospective sub-study of the LION trial

2020 ◽  
Vol 30 (10) ◽  
pp. 1548-1553 ◽  
Author(s):  
Annette Hasenburg ◽  
Jalid Sehouli ◽  
Bjoern Lampe ◽  
Alexander Reuss ◽  
Barbara Schmalfeld ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Sexual Function ◽  
Radical Surgery ◽  
Performance Status ◽  
Advanced Ovarian Cancer ◽  
Sexually Active ◽  
Limited Information ◽  
Platinum Based Chemotherapy ◽  
Eortc Qlq ◽  
The Impact

BackgroundThere is limited information about the impact of radical surgery including pelvic and para-aortic lymphadenectomy and subsequent platinum-based chemotherapy on sexuality in patients with advanced ovarian cancer.ObjectiveTo evaluate the impact of radical surgery including pelvic and para-aortic lymphadenectomy and subsequent platinum-based chemotherapy on sexuality in patients with advanced ovarian cancer as a sub-protocol of the prospectively randomized LION trial.MethodsThe Sexual Activity Questionnaire was applied to assess sexual function according to its sub-scales activity, pleasure, and discomfort. The 'orgasm' sub-scale from the Female Sexual Function Index was also added. The questionnaire was administered in combination with the EORTC QLQ-C30 questionnaire at baseline prior surgery, after 6, 12, and 24 months. The primary endpoint was changes in sexual function.ResultsOverall, 495 patients received the questionnaires. 254 (51%) responded at baseline. Of these, 55 (22%) patients were sexually active, 182 (72%) were sexually inactive, and for 17 (7%) patients' data were not available. There was a total of 55/495 (11%) patients at 6 months, 139 (28%) patients at 12 months, and 81 (16%) patients at 24 months. Median age was 60.5 years (range 21.4–75.8). At baseline, sexually active responders were significantly younger (median age 51.5 years,) than sexually inactive responders (median age 61.8 years) and tended to have a better performance status. Discomfort evaluated as dryness of the vagina and pain during sexual intercourse was significantly worse at 12 months than at baseline (p<0.001); however, the surgical variable, lymphadenectomy, did not have any impact on this. The orgasm sub-scale showed diverging results with a deterioration from baseline to 12 months in the lymphadenectomy group compared with the no-lymphadenectomy group (p=0.02).ConclusionThe majority of patients were sexually inactive; however, in those who were sexually active, pain during intercourse was worse at 12 months. In addition, the orgasm sub-scale demonstrated worse results in patients who underwent complete lymphadenectomy. The study suggests that surgery in the retroperitoneal space may influence sexual function.

Preliminary results from the Sexual Therapy and Rehabilitation after Treatment for Ovarian Cancer (START-OC) study.

2016 ◽  
Vol 34 (3_suppl) ◽  
pp. 127-127
Author(s):  
Sharon L. Bober ◽  
Jaime E. Blackmon ◽  
Christopher J. Recklitis ◽  
Alexi A. Wright
Keyword(s):  
Ovarian Cancer ◽  
Sexual Dysfunction ◽  
Self Efficacy ◽  
Group Intervention ◽  
Group Session ◽  
Eligibility Criteria ◽  
Sexual Therapy ◽  
Quantitative Analyses ◽  
Feedback Data

127 Background: For ovarian cancer (OC) survivors, serious sexual dysfunction is one of the most distressing long-term side effects of treatment, with up to 90% survivors reporting a loss of interest in sexual activity for years after diagnosis. Despite the prevalence and magnitude of the problem, treatment-related sexual dysfunction and accompanying psychological distress are not addressed for most survivors. There is a critical need to address these problems for OC survivors. Methods: We are currently piloting a novel psychosexual intervention to help women manage sexual changes and improve sexual functioning after ovarian cancer treatment. Guided by Self-Determination Theory, this group-based intervention also aims to enhance women’s self-efficacy to address problems. Eligibility criteria include: OC diagnosis, functional ability, and sexual dysfunction. Women participate in a single half-day workshop, complete questionnaires, and engage in a booster telephone session. Detailed workshop evaluations are collected to assess women’s feedback of the group session. This study is currently enrolling. Results: To date, 369 women have been contacted, of which 45 (12.2%) have attended or are scheduled to attend a group session. Preliminary feedback data indicate high favorability of the group session; 100% of the women (N = 16) agreed or strongly agreed that the content of the group session was easy to understand and that the group session gave helpful information for addressing treatment-related sexual problems. Additionally, 100% of participants agreed that they were satisfied with the group session and enjoyed participating in it. Conclusions: Preliminary data show that women report multiple benefits from the session content and are highly satisfied with the group session. However, low response rates raise several questions with regard to timing and recruitment of a sexual health intervention after OC treatment. Next steps include quantitative analyses of changes in sexual function, sexual knowledge, and sexual self-efficacy consequent to the group intervention. Clinical trial information: NCT02287519.

scholarly journals Long-term quality of life and sexual function of elderly people with endometrial or ovarian cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ariane Mamguem Kamga ◽  
Leila Bengrine-Lefevre ◽  
Valérie Quipourt ◽  
Laure Favier ◽  
Ariane Darut-Jouve ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Ovarian Cancer ◽  
Sexual Function ◽  
Physical Functioning ◽  
Bodily Pain ◽  
Anxiety Depression ◽  
The Impact

Abstract Background With the growing number of older endometrial cancer (EC) and ovarian cancer (OC) survivors, data on long-term health-related quality of life (HRQoL) became an important issue in the management of older patients. So, the aim of this study was to describe and compare according to age long-term HRQoL, sexual function, and social deprivation of adults with either EC or OC. Methods A cross-sectional study was set up using data from the Côte d’Or gynecological cancer registry. A series of questionnaires assessing HRQoL (SF-12), sexual function (FSFI), anxiety/depression (HADS), social support (SSQ6) and deprivation (EPICES) were offered to women with EC or OC diagnosed between 2006 and 2013. HRQoL, sexual function, anxiety/depression, social support and deprivation scores were generated and compared according to age (< 70 years and ≥ 70 years). Results A total of 145 women with EC (N = 103) and OC (N = 42) participated in this study. Fifty-six percent and 38% of EC and OC survivors respectively were aged 70 and over. Treatment did not differ according to age either in OC or EC. The deprivation level did not differ between older and younger survivors with OC while older survivors with EC were more precarious. The physical HRQoL was more altered in older EC survivors. This deterioration concerned only physical functioning (MD = 24, p = 0.012) for OC survivors while it concerned physical functioning (MD = 30, p < 0.0001), role physical (MD = 22, p = 0.001) and bodily pain (MD = 21, p = 0.001) for EC survivors. Global health (MD = 11, p = 0.011) and role emotional (MD = 12, p = 0.018) were also deteriorated in elderly EC survivors. Sexual function was deteriorated regardless of age and cancer location with a more pronounced deterioration in elderly EC survivors for desire (p = 0.005), arousal (p = 0.015) and orgasm (p = 0.007). Social support, anxiety and depression were not affected by age regardless of location. Conclusion An average 6 years after diagnosis, the impact of cancer on HRQoL is greatest in elderly survivors with either EC or OC.

Young Women Diagnosed with Early-Stage Ovarian Cancer or Borderline Malignancy of the Ovary: A Focus on Fertility and Sexual Function

2012 ◽  
Vol 30 (4) ◽  
pp. 387-401 ◽  
Author(s):  
Susana M. Campos ◽  
Suzanne Berlin ◽  
Ursula A. Matulonis ◽  
Michael G. Muto ◽  
Lauren Pereira ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Sexual Function ◽  
Young Women ◽  
Early Stage ◽  
Borderline Malignancy ◽  
Early Stage Ovarian Cancer

Sexual function and quality of life of patients affected by ovarian cancer

2019 ◽  
Vol 110 (4) ◽  
Author(s):  
Stefano Cianci ◽  
Mattia Tarascio ◽  
Andrea Rosati ◽  
Salvatore Caruso ◽  
Stefano Uccella ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ovarian Cancer ◽  
Sexual Function

scholarly journals Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal (PROTECTOR): protocol for a prospective non-randomised multi-center trial

2020 ◽  
pp. ijgc-2020-001541
Author(s):  
Faiza Gaba ◽  
Sadiyah Robbani ◽  
Naveena Singh ◽  
W Glenn McCluggage ◽  
Nafisa Wilkinson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ovarian Cancer ◽  
Family History ◽  
Sexual Function ◽  
Endocrine Function ◽  
Exclusion Criteria ◽  
Increased Risk ◽  
Menopausal Women ◽  
Risk Reducing

BackgroundRisk-reducing salpingo-oophorectomy is the 'gold standard' for preventing tubo-ovarian cancer in women at increased risk. However, when performed in pre-menopausal women, it results in premature menopause and associated detrimental health consequences. This, together with acceptance of the central role of the fallopian tube in etiopathogenesis of high-grade serous carcinoma, by far the most common type of tubo-ovarian cancer, has led to risk-reducing early salpingectomy with delayed oophorectomy being proposed as a two-step surgical alternative for pre-menopausal women declining/delaying oophorectomy.Primary ObjectiveTo evaluate the impact on sexual function of risk-reducing early salpingectomy, within a two-step, risk-reducing, early salpingectomy with delayed oophorectomy tubo-ovarian cancer prevention strategy in pre-menopausal women at increased risk of tubo-ovarian cancer.Study HypothesisRisk-reducing early salpingectomy is non-inferior for sexual and endocrine function compared with controls; risk-reducing early salpingectomy is superior for sexual/endocrine function, non-inferior for quality-of-life, and equivalent in satisfaction to the standard risk-reducing salpingo-oophorectomy.Trial DesignMulti-center, observational cohort trial with three arms: risk-reducing early salpingectomy with delayed oophorectomy; risk-reducing salpingo-oophorectomy; controls (no surgery). Consenting individuals undergo an ultrasound, serum CA125, and follicle-stimulating hormone measurements and provide information on medical history, family history, quality-of-life, sexual function, cancer worry, psychological well-being, and satisfaction/regret. Follow-up by questionnaire takes place annually for 3 years. Women receiving risk-reducing early salpingectomy can undergo delayed oophorectomy at a later date of their choosing, or definitely by the menopause.Major Inclusion/Exclusion CriteriaInclusion criteria: pre-menopausal; aged >30 years; at increased risk of tubo-ovarian cancer (mutation carriers or on the basis of a strong family history); completed their family (for surgical arms). Exclusion criteria: post-menopausal; previous bilateral salpingectomy or bilateral oophorectomy; pregnancy; previous tubal/ovarian/peritoneal malignancy; <12 months after cancer treatment; clinical suspicion of tubal/ovarian cancer at baseline.Primary EndpointSexual function measured by validated questionnaires.Sample Size1000 (333 per arm).Estimated Dates for Completing Accrual and Presenting ResultsIt is estimated recruitment will be completed by 2023 and results published by 2027.Trial Registration NumberISRCTN registry: 25 173 360 (https://doi.org/10.1186/ISRCTN25173360).

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