scholarly journals Mindfulness practice reduces cortisol blunting during chemotherapy: A randomized controlled study of colorectal cancer patients

Cancer ◽  
2017 ◽  
Vol 123 (16) ◽  
pp. 3088-3096 ◽  
Author(s):  
David S. Black ◽  
Cheng Peng ◽  
Alix G. Sleight ◽  
Nathalie Nguyen ◽  
Heinz-Josef Lenz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Mindfulness Practice ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Colorectal Cancer Patients

The role of reduced glutathione on oxaliplatin-induced neuropathy in colorectal cancer patients

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19539-19539
Author(s):  
G. Lelli ◽  
G. Romano ◽  
R. Ardito ◽  
A. Bochicchio ◽  
A. Capobianco ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Sensory Neuropathy ◽  
Treatment Interruption ◽  
Sensory Loss ◽  
Controlled Study ◽  
Common Side Effect ◽  
Oxaliplatin Treatment ◽  
Randomised Controlled ◽  
Colorectal Cancer Patients

19539 Background: Peripheral sensory neuropathy is a common side-effect of oxaliplatin based chemotherapy. The neuropathy is cumulative and dose-related. Symptoms include sensory ataxia and dysesthesia of the limbs, mouth, throat and larynx, and may be exacerbated by exposure to cold. Studies suggest that Glutathione (GSH) is neuroprotective against oxaliplatin-induced neuropathy. Methods: From Jan. 2004, 83 consecutive colorectal cancer patients (pts) elegibile to oxaliplatin-based regimen were treated with GSH 1500 mg/mq over a 15-minute infusion period before oxaliplatin. Treatment-related toxicity was evaluated based on National Cancer Institute (NCI) Criteria. Results: After four cycles of chemotherapy, 5 pts (6%) experienced G1 neurotoxicity. After eight cycles, 2 pts (2.4%) experienced G2 sensory neuropathy (duration < 7 days) and 8 (9.6%) pts G1. After 12 cycles, G3 sensory neuropathy was observed in 2 pts (2.4%), G2 in 8 (9.6%) and G1 in 11 pts (13%). Neither G4 sensory neuropathy was registered nor treatment interruption was required. Conclusions: These findings suggest that use of GSH may protect from oxaliplatin-induced neuropathy. In fact, in our series, only 2 (2.4%) pts experienced severe paresthesia interfering with daily activities and none hade permanent sensory loss. However, only a well designed randomised controlled study will definitely prove the protective effect of GSH on oxaliplatin induced neurotoxicity. No significant financial relationships to disclose.

Randomized Controlled Study to Evaluate the Efficacy of a Preoperative Respiratory Rehabilitation Program to Prevent Postoperative Pulmonary Complications after Esophagectomy

2015 ◽  
Vol 32 (5) ◽  
pp. 331-337 ◽  
Author(s):  
Ippei Yamana ◽  
Shinsuke Takeno ◽  
Tatsuya Hashimoto ◽  
Kenji Maki ◽  
Ryosuke Shibata ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Patients ◽  
Rehabilitation Program ◽  
Pulmonary Complications ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Postoperative Pulmonary Complications ◽  
Postoperative Rehabilitation ◽  
Randomized Controlled ◽  
Respiratory Rehabilitation

Background/Aims: Patients with postoperative pulmonary complications after esophagectomy often have increased mortality. The purpose of the study was to examine the efficacy of preventing postoperative pulmonary complications by an intensive preoperative respiratory rehabilitation (PR) program for esophageal cancer patients. Methods: This study was a prospective randomized controlled study. Thirty patients in the PR group and 30 patients in the no preoperative respiratory rehabilitation (NPR) group were included. The PR group received preoperative rehabilitation for more than 7 days, while the NPR group did not receive any preoperative rehabilitation. All patients underwent postoperative rehabilitation from the first postoperative day. The postoperative pulmonary complications were evaluated using the Clavien-Dindo classification (CDC) and the Utrecht Pneumonia Scoring System (UPSS). Results: The CDC grade in the PR group was significantly lower than that in the NPR group (p = 0.014). The UPSS score in the PR group was significantly lower than that in the NPR group at postoperative day 1 (p = 0.031). In the multivariate analysis, NPR was an independent risk factor for postoperative pulmonary complications greater than CDC grade II (OR: 3.99, 95% CI: 1.28-12.4, p = 0.017). Conclusions: This study showed that the intensive PR program was capable of reducing the postoperative pulmonary complications in esophageal cancer patients.

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