scholarly journals Impact of fecal immunochemical test-based screening programs on proximal and distal colorectal cancer surgery rates: A natural multiple-baseline experiment

Cancer ◽  
2015 ◽  
Vol 121 (22) ◽  
pp. 3982-3989 ◽  
Author(s):  
Ugo Fedeli ◽  
Manuel Zorzi ◽  
Emanuele D.L. Urso ◽  
Nicola Gennaro ◽  
Angelo P. Dei Tos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Surgery ◽  
Fecal Immunochemical Test ◽  
Multiple Baseline ◽  
Colorectal Cancer Surgery ◽  
Screening Programs ◽  
Immunochemical Test ◽  
Surgery Rates ◽  
Baseline Experiment

Factors Associated with Participation in Colorectal Cancer Screening Using a Fecal Immunochemical Test (FIT) in Thai Population Aged 45 to 74 years in Namphong District, Khon Kaen Province

2021 ◽  
Vol 104 (7) ◽  
pp. 1067-1072
Keyword(s):  
Public Health ◽  
Colorectal Cancer ◽  
Fecal Immunochemical Test ◽  
Thai Population ◽  
Screening Programs ◽  
Crc Screening ◽  
Factors Associated ◽  
History Of ◽  
Public Health Officials ◽  
Immunochemical Test

Background: Presently, the level of participation in screening programs for colorectal cancer (CRC) with Fecal Immunochemical Test (FIT) is considerably low. Objective: To investigate factors associated with participation in CRC screening using a FIT in the Thai population age 45 to 74 years in the Namphong District of Khon Kaen Province. Materials and Methods: In the present study, the unmatched case-control study design was applied. Three hundred ten participants were equally divided into two groups with 155 participants in the study group and the other 155 in the control group. The data were collected by conducting interviews. Moreover, to explain the association between the factors, multiple logistic regressions were used with adjusted odds ratio (ORadj), a confidence level at 95%, and with p<0.05. Results: It was found that ages were equal to or higher than 60 years (ORadj 2.08; 95%CI 1.19 to 3.63), the lower education level (ORadj 3.70; 95% CI 1.86 to 7.33), a family history of cancer (ORadj 5.25; 95% CI 2.14 to 12.86), receiving advice from public health officials regarding CRC screening (ORadj 3.09; 95% CI 1.81 to 5.27), and high level of knowledge about CRC (ORadj 4.01; 95% CI 2.09 to 7.69) had all been related to participation in the CRC screening program with a statistical significance (p<0.05). Conclusion: The results revealed that receiving advice from public health officials regarding CRC screening and that proper knowledge had been related to participation in screening programs for CRC with the FIT. Thus, to raise awareness and create a greater understanding, public health officers should disseminate knowledge about CRC. Information about the colorectal screening with the FIT should especially be spread to those people who are younger than 60 years of age, have educational levels higher than the primary level, and to those, who have no family history of CRC. Keywords: Colorectal Cancer Screening; Fecal Immunochemical Test (FIT); Thai population

scholarly journals New fecal bacterial signature for colorectal cancer screening reduces the fecal immunochemical test false-positive rate in a screening population

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243158
Author(s):  
Marta Malagón ◽  
Sara Ramió-Pujol ◽  
Marta Serrano ◽  
Joan Amoedo ◽  
Lia Oliver ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
False Positive ◽  
False Positive Rate ◽  
Fecal Immunochemical Test ◽  
Noninvasive Test ◽  
Screening Programs ◽  
Crc Screening ◽  
Positive Rate ◽  
Immunochemical Test ◽  
Advanced Adenomas

Guidelines recommend routine screening for colorectal cancer (CRC) in asymptomatic adults starting at age 50. The most extensively used noninvasive test for CRC screening is the fecal immunochemical test (FIT), which has an overall sensitivity for CRC of approximately 61.0%-91.0%, which drops to 27.0%-67.0% for advanced adenomas. These figures contain a high false-positive rate and a low positive predictive value. This work aimed to develop a new, noninvasive CRC screening tool based on fecal bacterial markers capable of decreasing FIT false-positive rates in a FIT-positive population. We defined a fecal bacterial signature (RAID-CRC Screen) in a proof-of-concept with 172 FIT-positive individuals and validated the obtained results on an external cohort of 327 FIT-positive subjects. All study participants had joined the national CRC screening program. In the clinical validation of RAID-CRC Screen, a sensitivity of 83.9% and a specificity of 16.3% were obtained for the detection of advanced neoplasm lesions (advanced adenomas and/or CRC). FIT 20 μg/g produced 184 false-positive results. Using RAID-CRC Screen, this value was reduced to 154, thus reducing the false-positive rate by 16.3%. The RAID-CRC Screen test could be implemented in CRC screening programs to allow a significant reduction in the number of colonoscopies performed unnecessarily for FIT-positive participants of CRC screening programs.

scholarly journals Polyprev: Randomized, Multicenter, Controlled Trial Comparing Fecal Immunochemical Test with Endoscopic Surveillance after Advanced Adenoma Resection in Colorectal Cancer Screening Programs: A Study Protocol

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1520
Author(s):  
Cristina Regueiro ◽  
Raquel Almazán ◽  
Isabel Portillo ◽  
María Besó ◽  
Carlos Tourne-Garcia ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Practice ◽  
Diagnostic Yield ◽  
Fecal Immunochemical Test ◽  
Endoscopic Surveillance ◽  
Advanced Adenoma ◽  
Colonic Lesion ◽  
Screening Programs ◽  
Crc Screening ◽  
Immunochemical Test

Colorectal cancer (CRC) screening programs have been implemented to reduce the burden of the disease. When an advanced colonic lesion is detected, clinical practice guidelines recommend endoscopic surveillance with different intervals between explorations. Endoscopic surveillance is producing a considerable increase in the number of colonoscopies, with a limited effect on the CRC incidence. Instead, participation in CRC screening programs based on the fecal immunochemical test (FIT) could be a non-inferior alternative to endoscopic surveillance to reduce 10-year CRC incidence. Based on this hypothesis, we have designed a multicenter and randomized clinical trial within the Spanish population CRC screening programs to compare FIT surveillance with endoscopic surveillance. We will include individuals aged from 50 to 65 years with complete colonoscopy and advanced lesions resected within the CRC screening programs. Patients will be randomly allocated to perform an annual FIT and colonoscopy if fecal hemoglobin concentration is ≥10 µg/g, or to perform endoscopic surveillance. On the basis of the non-superior CRC incidence, we will recruit 1894 patients in each arm. The main endpoint is 10-year CRC incidence and the secondary endpoints are diagnostic yield, participation, adverse effects, mortality and cost-effectiveness. Our results may modify the clinical practice after advanced colonic resection in CRC screening programs.

scholarly journals Colorectal cancer screening: foreign guidelines on fecal immunochemical test cut-off (review)

2021 ◽  
Vol 67 (4) ◽  
pp. 456-462
Author(s):  
Dmitrii Andreev ◽  
Asan Kashurnikov ◽  
Aleksandr Zavyalov
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Hemoglobin Concentration ◽  
Fecal Immunochemical Test ◽  
Screening Programs ◽  
Wide Range ◽  
Positive Threshold ◽  
Immunochemical Test ◽  
Threshold Setting

Introduction. According to WHO data for 2020, colorectal cancer occupies first (highest) position (excluding non-melanoma skin cancer) in the top ranking list of the most frequent cancers in the Russian Federation.  Colorectal cancer screening plays a pivotal role in early diagnosis and treatment. The best positive threshold values for hemoglobin concentration in a quantitative fecal immunochemical test (FIT) are postulated in a fraction of foreign recommendations. We reviewed the FIT cut-off values in those clinical guidelines. Materials and methods. The relevant publications were retrieved from PubMed and Google. The search horizon covered the last decade. Searches used the terms: «fecal immunochemical test» AND «screening» OR «cancer» AND «colorectal» OR «colon» OR «rectum", as well as other semantic and thematic forms. The recommendations appeared in last decade were reviewed. Results. This review summarizes the cut-off values for hemoglobin concentration in FIT, included in the clinical and laboratory guidelines developed in such regions as: Europe, Canada, USA, New Zealand. Many CRC screening programs use the FIT with a threshold setting for interpreting a positive test result. In practice, a wide range of options for threshold hemoglobin concentrations is used to interpret positive results of quantitative FIT. The FIT cut-off value is critically important to select the size of population for further examination depending on capacity of colonoscopy units. Discussion and conclusions. The foreign guidelines don’t establish single unified approach for FIT results interpretation, which would be an optimal fit for all imaginable practical situations in healthcare system. Improvement of screening techniques based on FIT would lead to the further steps on the way towards more effective and safe CRC diagnosis.

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