scholarly journals Impact of biochemical failure classification on clinical outcome: A secondary analysis of Radiation Therapy Oncology Group 9202 and 9413

Cancer ◽  
2014 ◽  
Vol 121 (6) ◽  
pp. 844-852 ◽  
Author(s):  
Daniel A. Hamstra ◽  
Kyounghwa Bae ◽  
Gerald Hanks ◽  
Chen Hu ◽  
William U. Shipley ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Clinical Outcome ◽  
Radiation Therapy Oncology Group ◽  
Secondary Analysis ◽  
Biochemical Failure ◽  
Oncology Group ◽  
Failure Classification

scholarly journals Short Delay in Initiation of Radiotherapy May Not Affect Outcome of Patients With Glioblastoma: A Secondary Analysis From the Radiation Therapy Oncology Group Database

2009 ◽  
Vol 27 (5) ◽  
pp. 733-739 ◽  
Author(s):  
Deborah T. Blumenthal ◽  
Minhee Won ◽  
Minesh P. Mehta ◽  
Walter J. Curran ◽  
Luis Souhami ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Radiation Therapy ◽  
Treatment Regimen ◽  
Radiation Therapy Oncology Group ◽  
Secondary Analysis ◽  
Time Interval ◽  
Oncology Group ◽  
Survival Times ◽  
Short Delay ◽  
Time To Initiation

Purpose To analyze the Radiation Therapy Oncology Group (RTOG) database of patients with glioblastoma and appraise whether outcome was influenced by time to initiation of radiation therapy (RT). Patients and Methods From 1974 through 2003, adult patients with histologically confirmed supratentorial glioblastoma were enrolled onto 16 RTOG studies. Of 3,052 enrolled patients, 197 patients (6%) were either initially rendered ineligible or had insufficient chronologic data, leaving a cohort of 2,855 patients for the present analysis. We selected four patient groups based on the interval from surgery to the start of RT: ≤ 2 weeks, 2 to 3 weeks, 3 to 4 weeks, more than 4 weeks to the protocol eligibility limit of 6 weeks. Survival times were estimated by the Kaplan-Meier method. Multivariate analysis incorporated variables of time interval, recursive partitioning analysis (RPA) class, and treatment regimen. Results No decrement in survival could be identified with increasing time to initiation of RT. Among our four temporal groupings, median survival time was unexpectedly and significantly greater in the group with the longest interval (> 4 weeks) than in those with the shortest delay (≤ 2 weeks): respectively, 12.5 months versus 9.2 months (P < .0001). On multivariate analysis, with overall survival as the end point, time interval more than 4 weeks and lower RPA class were both significant predictors of improved outcome. Treatment regimen was not a significant factor. Conclusion There is no evident reduction in survival by delaying initiation of RT within the relatively narrow constraint of 6 weeks. An unanticipated yet significantly superior outcome was identified for patients for whom RT was delayed beyond 4 weeks from surgery.

Does Timing of Androgen Deprivation Influence Radiation-Induced Toxicity? A Secondary Analysis of Radiation Therapy Oncology Group Protocol 9413

Urology ◽  
2008 ◽  
Vol 72 (5) ◽  
pp. 1125-1129 ◽  
Author(s):  
Daniel Taussky ◽  
Kyounghwa Bae ◽  
Jean-Paul Bahary ◽  
Mack Roach ◽  
Colleen A. Lawton ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Radiation Therapy Oncology Group ◽  
Secondary Analysis ◽  
Androgen Deprivation ◽  
Oncology Group ◽  
Radiation Induced

Activated STAT3 as a Correlate of Distant Metastasis in Prostate Cancer: A Secondary Analysis of Radiation Therapy Oncology Group 86-10

Urology ◽  
2007 ◽  
Vol 69 (3) ◽  
pp. 505-509 ◽  
Author(s):  
Javier F. Torres-Roca ◽  
Michelle DeSilvio ◽  
Linda B. Mora ◽  
Li Yan Khor ◽  
Elizabeth Hammond ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Distant Metastasis ◽  
Radiation Therapy Oncology Group ◽  
Secondary Analysis ◽  
Oncology Group
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