scholarly journals Lifestyle and metabolic syndrome in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study

Cancer ◽  
2014 ◽  
Vol 120 (17) ◽  
pp. 2742-2750 ◽  
Author(s):  
Webb A. Smith ◽  
Chenghong Li ◽  
Kerri A. Nottage ◽  
Daniel A. Mulrooney ◽  
Gregory T. Armstrong ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Childhood Cancer ◽  
Adult Survivors ◽  
Survivors Of Childhood Cancer

scholarly journals Cardiac remodeling after anthracycline and radiotherapy exposure in adult survivors of childhood cancer: A report from the St Jude Lifetime Cohort Study

Cancer ◽  
2021 ◽  
Author(s):  
John L. Jefferies ◽  
Wojciech M. Mazur ◽  
Carrie R. Howell ◽  
Juan C. Plana ◽  
Kirsten K. Ness ◽  
...  
Keyword(s):  
Cohort Study ◽  
Childhood Cancer ◽  
Cardiac Remodeling ◽  
Adult Survivors ◽  
Survivors Of Childhood Cancer

scholarly journals Career readiness in adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort Study

2014 ◽  
Vol 9 (1) ◽  
pp. 20-29 ◽  
Author(s):  
David Strauser ◽  
James L. Klosky ◽  
Tara M. Brinkman ◽  
Alex W. K. Wong ◽  
Fong Chan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Childhood Cancer ◽  
Adult Survivors ◽  
Career Readiness ◽  
Survivors Of Childhood Cancer

scholarly journals METABOLIC SYNDROME PARAMETERS, DETERMINANTS, AND BIOMARKERS IN ADULT SURVIVORS OF CHILDHOOD CANCER: PROTOCOL OF THE DUTCH CHILDHOOD CANCER SURVIVOR STUDY METABOLIC SYNDROME (DUTCH LATER METS STUDY) (Preprint)

2020 ◽  
Author(s):  
Vincent Pluimakers ◽  
Marta Fiocco ◽  
Jenneke van Atteveld ◽  
Monique Hobbelink ◽  
Dorine Bresters ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Previous Treatment ◽  
Adult Survivors ◽  
Childhood Cancer Survivors ◽  
Snp Analysis ◽  
Cross Sectional ◽  
Survivors Of Childhood Cancer

BACKGROUND Potential late effects of treatment for childhood cancer include adiposity, insulin resistance, dyslipidemia and hypertension. These risk factors cluster together as metabolic syndrome (MetS) and increase the risk for development of diabetes mellitus and cardio- and cerebrovascular disease. Knowledge on risk factors, timely diagnosis and preventive strategies is of importance to prevent cardio- and cerebrovascular complications and improve quality of life. Currently, no studies in national cohorts on prevalence and determinants of MetS in childhood cancer survivors including biomarkers and genetic predisposition are available. OBJECTIVE The objectives of the Dutch LATER METS study are to assess 1) the prevalence and risk factors of MetS and its separate components, and 2) the potential value of additional biomarkers, in the national cohort of adult long-term survivors of childhood cancer. METHODS This is a cross-sectional study, based on recruitment of all survivors treated in the Netherlands between 1963 and 2002. MetS will be classified according to the definitions of the National Cholesterol Education Program (NCEP-ATP III) as well as the Joint Interim Statement (JIS), and compared to reference data. Dual-energy X-ray absorptiometry (DXA) scans were performed to assess body composition in more detail. The effect of patient characteristics, previous treatment, and genetic variation on the risk of MetS will be assessed. The diagnostic and predictive value of novel biomarkers will be tested. RESULTS Patient accrual started in 2016 and lasted until April 2020. A total of 2380 survivors has participated, in seven pediatric oncology hospitals. From July 2020, biomarker testing, SNP analysis and data analysis will be performed. CONCLUSIONS The Dutch LATER METS study will provide knowledge on clinical and genetic determinants of MetS, and the diagnostic value of biomarkers, in childhood cancer survivors. The results of this study will be used to optimize surveillance guidelines for MetS in survivors, based on enhanced risk stratification and screening strategies. This will improve diagnosis of MetS, and prevent complications. CLINICALTRIAL Registered at toetsingonline.nl, NL32117.018.10

Metabolic syndrome in adult survivors of childhood cancer.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e22102-e22102
Author(s):  
Aruna Alahari Dhir ◽  
Anuprita Daddi ◽  
Sheela Sawant ◽  
Maya Prasad
Keyword(s):  
Metabolic Syndrome ◽  
Childhood Cancer ◽  
Adult Survivors ◽  
Survivors Of Childhood Cancer

Emotional distress, stress, and cardiovascular health in adult survivors of childhood cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 10547-10547
Author(s):  
Margaret M. Lubas ◽  
Mingjuan Wang ◽  
John L. Jefferies ◽  
Kirsten K. Ness ◽  
Matthew J. Ehrhardt ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Metabolic Syndrome ◽  
Childhood Cancer ◽  
Emotional Distress ◽  
Cardiovascular Health ◽  
Adult Survivors ◽  
Cardiac Health ◽  
Survivors Of Childhood Cancer ◽  
New Onset

10547 Background: The contribution of emotional distress and stress to cardiac health in adult survivors of childhood cancer has not been reported, despite evidence of causal associations in the general population. Methods: Comprehensive medical assessments and standardized measures of depression, anxiety, post-traumatic stress disorder, and perceived stress were performed on 3,267 survivors in the St. Jude Lifetime Cohort (median[range] 29.9[18.0-64.5] years of age; 7.7[0-24.8] years at diagnosis; 49% female). Physical outcomes included hypertension, diabetes, dyslipidemia, cardiomyopathy, dysrhythmia (grades 2-4 per the NCI CTCAE criteria), myocardial infarction (grades 3-4), and metabolic syndrome (yes/no). Multivariable generalized linear models examined associations between these outcomes with any distress/stress, adjusted for demographics, cumulative anthracycline dose and thoracic radiation, physical activity, BMI, smoking, and alcohol intake. Unadjusted longitudinal associations between distress/stress and new onset cardiac conditions were examined among survivors who completed repeat medical assessment(s) (n = 1748; median follow-up = 3.9 years). New onset conditions were defined as a change from grade 0-1 at baseline to ≥ grade 2 at follow-up. Results: Survivor reported distress/stress (29% overall) was more prevalent in those with hypertension (28.2% vs 19.5%, P< 0.001), dyslipidemia (16.4% vs. 11.3%, P< 0.001), diabetes (9.4% vs. 6.9%, P= 0.02), and metabolic syndrome (32.2% vs. 23.2%, P< 0.001), but not among dysrhythmia, cardiomyopathy, and myocardial infarction. In separate multivariable models, distress/stress was associated with hypertension (RR = 1.24, 95% CI 1.07-1.43), dyslipidemia (RR = 1.29, 95% CI 1.03-1.61), and metabolic syndrome (RR = 1.35, 95% CI 1.17-1.54). Baseline distress/stress was associated with new onset hypertension (OR = 1.33, 95% CI 0.94-2.01), dyslipidemia (OR = 1.37, 95% CI 0.94-1.87), and dysrhythmia (OR = 2.78, 95% CI 1.12-6.91). Conclusions: Emotional distress/stress is associated with adverse cardiovascular health and may serve as an intervention target for improving cardiac health outcomes among survivors of childhood cancer.

Components of the Metabolic Syndrome in 500 Adult Long-Term Survivors of Childhood Cancer.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 3068-3068
Author(s):  
Marjolein van Waas ◽  
Sebastian Neggers ◽  
Rob Pieters ◽  
M.M. Van Den Heuvel
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Childhood Cancer ◽  
Total Cholesterol ◽  
Conflicts Of Interest ◽  
Adult Survivors ◽  
Cranial Irradiation ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Survivors Of Childhood Cancer

Abstract Abstract 3068 Poster Board III-5 Introduction Adult survivors of childhood cancer have been reported to have an increased risk of late sequels. A cluster of abnormalities that contribute to the metabolic syndrome may be expressed at a higher level and therefore result in an increased risk for diabetes mellitus and cardiovascular diseases. Patients and Methods We investigated a single centre cohort of 500 adult survivors (228 females) of childhood cancer, median age 28 years (range 18-59 years) and median follow-up time 19 years (range 6–49 years). This cohort included 164 acute lymphoblastic leukaemia (ALL) survivors (75 females). We measured total cholesterol, high-density lipoprotein-cholesterol (HDL), systolic and diastolic blood pressure, body mass index and the prevalence of diabetes mellitus. Data from the Dutch epidemiologic MORGEN-study were used to calculate standard deviation scores as normative values. Results The criteria of the metabolic syndrome were met in 13% of the total cohort. ALL survivors treated with cranial irradiation had an increased risk of developing the metabolic syndrome compared to ALL survivors not treated with cranial irradiation (23% vs. 7%, P=0.011). ALL survivors who received CRT had higher total cholesterol levels compared to ALL survivors who did not (mean SDS 0.38 vs. mean SDS –0.05, P=0.027), whereas their HDL levels did not differ. Also, ALL survivors treated with CRT were more often hypertensive compared to ALL survivors not treated with CRT (22% vs. 10%, P=0.036) and more often overweight (59% vs. 34%, P=0.003), however they were not more often obese (12% vs. 9%, ns). Conclusions Adult survivors of childhood cancer, especially ALL survivors treated with cranial irradiation, are at increased risk of developing the metabolic syndrome. This increased risk is probably determined by higher prevalence of overweight and hypertension in ALL survivors. Disclosures No relevant conflicts of interest to declare.

scholarly journals Validity of anthropometric measurements for characterizing obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study

Cancer ◽  
2015 ◽  
Vol 121 (12) ◽  
pp. 2036-2043 ◽  
Author(s):  
Robyn E. Karlage ◽  
Carmen L. Wilson ◽  
Nan Zhang ◽  
Sue Kaste ◽  
Daniel M. Green ◽  
...  
Keyword(s):  
Cohort Study ◽  
Childhood Cancer ◽  
Adult Survivors ◽  
Anthropometric Measurements ◽  
Survivors Of Childhood Cancer
Sign in / Sign up

Export Citation Format

Share Document