scholarly journals Heart rate decrease during crizotinib treatment and potential correlation to clinical response

Cancer ◽  
2013 ◽  
Vol 119 (11) ◽  
pp. 1969-1975 ◽  
Author(s):  
Sai-Hong Ignatius Ou ◽  
Wilson P. Tong ◽  
Michele Azada ◽  
Christina Siwak-Tapp ◽  
Joni Dy ◽  
...  
Keyword(s):  
Heart Rate ◽  
Clinical Response ◽  
Rate Decrease ◽  
Heart Rate Decrease

Anxiety, Perception, and Control of Heart Rate

1984 ◽  
Vol 59 (1) ◽  
pp. 203-211 ◽  
Author(s):  
Vilfredo De Pascalis ◽  
Maria L. Alberti ◽  
Raffaele Pandolfo
Keyword(s):  
Heart Rate ◽  
Right Hemisphere ◽  
Cognitive Strategies ◽  
Significant Negative Correlation ◽  
Activity Levels ◽  
Heart Activity ◽  
Rate Decrease ◽  
Heart Rate Decrease ◽  
Relaxation Responses ◽  
The Right

8 women and 8 men took Cattell's IPAT-anxiety questionnaire and later McFarland's test of ability to perceive heart activity. The second test involved subjects' tracking their own heart rates, then they enrolled in an EKG biofeedback session to evaluate ability to increase and decrease heart rate from subjects' resting baselines. At the end of the session each subject completed Blanchard, et al.'s questionnaire to specify the cognitive strategies used for heart-rate control. Heart rate, abdominal respiration rate, respiration amplitude, EEG percent power in theta, alpha, and beta bands were evaluated. Success of heart-rate decrease seemed to depend mainly on activity levels: the subjects who achieved high scores on the activity test decreased heart rate significantly better than did low scorers. The relationship between scores for perception of heart and increases in heart rate was nonsignificant: increased heart-rate seemed to depend on differences in respiration between the rest and periods of increase. The significant, negative correlation between trait anxiety and perceptions of heart activity suggested that anxiety affected subjects' ability to perceive heart rate. The theta EEG power of the right hemisphere was significantly higher in subjects scoring high than for those low in perception of heart activity. During heart-rate increase tasks subjects mainly reported use of ‘arousal responses,’ similarly during heart-rate decrease tasks they reported use of relaxation responses.

IS BLUNTED HEART RATE DECREASE AT NIGHT ASSOCIATED TO PREVALENT ORGAN DAMAGE IN ESSENTIAL HYPERTENSION?

2011 ◽  
Vol 29 ◽  
pp. e1
Author(s):  
S. Meani ◽  
C. Cuspidi ◽  
F. Negri ◽  
C. Valerio ◽  
C. Sala ◽  
...  
Keyword(s):  
Heart Rate ◽  
Essential Hypertension ◽  
Organ Damage ◽  
Rate Decrease ◽  
Heart Rate Decrease

scholarly journals Intermittent vagus nerve stimulation allows preventing the “escape” effect of heart rhythm changes

2019 ◽  
Vol 24 (6) ◽  
pp. 674-683
Author(s):  
Ya. I. Poleshchenko ◽  
D. A. Oleynikov ◽  
V. Yu. Lukichev ◽  
D. A. Khromikhin ◽  
M. A. Krylova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Pulse Generator ◽  
Nerve Damage ◽  
Rate Decrease ◽  
Positive Effects ◽  
Heart Rate Decrease

Background.Vagus nerve stimulation has been proposed for the treatment of a number of diseases. The positive effects of vagus nerve stimulation on ischemic and reperfusion myocardial injury has been tested in experimental models. However, the escape effect of vagus activation on heart rate and the methodology to overcome this effect have not been reported properly.Objective. The purpose of the study is to evaluate parameters of prolonged stimulation that decrease heart rate and allow overcoming the escape effect of vagus nerve activation.Design and methods. We used Wistar rats (n = 9). Cervical section was performed under general anesthesia. Left vagus nerve isolated from adjacent tissue was contacted with custom stimulation electrodes and a custom pulse generator. Blood pressure was measured in the right common carotid artery. Limb electrocardiogram was continuously recorded. First, stimulation parameters repeatedly evoking vagal reaction (decrease in heart rate) without nerve damage were evaluated. Second, parameters of intermittent stimulation that allowed repeat and consistent heart rate decrease were assessed.Results. During experiments, in 5 animals the following parameters leading to sustained 30 ± 20 % heart rate reduction were found: rectangular pulse, 30 Hz, 0,5 ms, 1–2 V (0,6– 0,8 mA). Stimulation with 50 Hz frequency led to nerve damage in 1 case. Stimulation with 20 Hz frequency led to heart rate over-suppression of heart rate and blood pressure. Intermittent nerve stimulation was tested in 4 animals and led to repeated heart rate decrease by 38 ± 15 %. The parameters which helped to avoid escape effect on heart rate change were the following: the length of stimulation episode of 45 s and interruption of stimulation for 15 s.Conclusion. Intermittent electrical stimulation evokes vagal reactions on heart rate and allows overcoming the escape effect of vagal activation. 

scholarly journals Ultrasound-induced heart rate decrease: role of the vagus nerve

2015 ◽  
Vol 62 (2) ◽  
pp. 329-336 ◽  
Author(s):  
Olivia C. Coiado ◽  
Elaine B. Buiochi ◽  
William D. O'brien
Keyword(s):  
Heart Rate ◽  
Vagus Nerve ◽  
Rate Decrease ◽  
Heart Rate Decrease

scholarly journals Belching as a rare cause of sudden and short-lived heart rate decrease during exercise

2011 ◽  
Vol 151 (1) ◽  
pp. e19-e21
Author(s):  
Emanuel C. Furtado ◽  
João Felipe C. Franca ◽  
Claudio Gil S. Araújo
Keyword(s):  
Heart Rate ◽  
Rate Decrease ◽  
Heart Rate Decrease

Amphotericin-Induced Heart-Rate Decrease in Children

1995 ◽  
Vol 34 (7) ◽  
pp. 358-364 ◽  
Author(s):  
Maurice Levy ◽  
Jeanette Domaratzki ◽  
Gideon Koren
Keyword(s):  
Heart Rate ◽  
Rate Decrease ◽  
Heart Rate Decrease
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