scholarly journals The effect of copy number variation in the phase II detoxification genesUGT2B17andUGT2B28on colorectal cancer risk

Cancer ◽  
2013 ◽  
Vol 119 (13) ◽  
pp. 2477-2485 ◽  
Author(s):  
Andrea Y. Angstadt ◽  
Arthur Berg ◽  
Junjia Zhu ◽  
Paige Miller ◽  
Terryl J. Hartman ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Copy Number Variation ◽  
Phase Ii ◽  
Copy Number ◽  
Colorectal Cancer Risk ◽  
Number Variation

Germline Copy Number Variation and Cancer Risk

2012 ◽  
Author(s):  
Richarda M de Voer ◽  
Ramprasath Venkatachalam ◽  
Ad Geurts van Kessel ◽  
Roland P Kuiper
Keyword(s):  
Cancer Risk ◽  
Copy Number Variation ◽  
Copy Number ◽  
Number Variation

Abstract 4720: Genome-wide copy number variation and breast cancer risk: Preliminary report

2010 ◽  
Author(s):  
Kyoung-Mu Lee ◽  
Miey Park ◽  
Sang-Hoon Moon ◽  
Hyung-Chol Kim ◽  
Ji-Young Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Copy Number Variation ◽  
Copy Number ◽  
Preliminary Report ◽  
Genome Wide ◽  
Number Variation

Abstract 4281: Mitochondrial DNA copy number, urinary isoprostanes and colorectal cancer risk

2016 ◽  
Author(s):  
Bharat Thyagarajan ◽  
Renwei Wang ◽  
Woon-Puay Koh ◽  
Helene Barcelo ◽  
Jennifer Adams-Haduch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Cancer Risk ◽  
Copy Number ◽  
Colorectal Cancer Risk ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

The mutational landscape of circulating cell-free DNA to identify neoadjuvant chemotherapy response in colorectal cancer patients.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15096-e15096
Author(s):  
Yanlong Liu ◽  
Xiaoli Wei ◽  
Xinying Shi ◽  
Ying Yang ◽  
Lili Fu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Copy Number Variation ◽  
Cancer Patients ◽  
Candidate Genes ◽  
Copy Number ◽  
Free Dna ◽  
Number Variation ◽  
Colorectal Cancer Patients ◽  
Response To Neoadjuvant Chemotherapy

e15096 Background: The neoadjuvant chemotherapy plays an important role in the current treatment of colorectal cancer (CRC), even though parts of patients could not be benefit from it. This study was aimed to explore the specific mutational profile of plasma cell free DNA (cfDNA) in CRC patients with or without response to neoadjuvant chemotherapy. Methods: 16 eligible CRC patients were enrolled in this study from Harbin Medical University Cancer Hospital. These patients were divided into two groups: with response ( R, n = 8) and without response (NR, n = 8) to neoadjuvant chemotherapy. All patients received neoadjuvant chemotherapy and their baseline blood samples were collected. The cfDNA fragments were extracted for enrichment of a panel covering exon regions of 1,086 genes. Gene alterations were analyzed to investigate the relationship between genetic characterizations of cfDNA and response to neoadjuvant chemotherapy. Results: Principal component (PCA) analysis for copy number variation(CNV) of cfDNA differed significantly in two groups. In the R group, there were higher frequency CNV loss in ABL-1, ERBB3, SMO, IGF1R, AURKA, PDGFRA, IDH1, BRAF, PIK3CB, NRAS, NF1, MITF, PTCH1 genes, and CNV gain in MTRR, HSP90AA1, VHL, CREBBP, CHEK2, DDR2, MUTYH, NCOA1, XPC, FANCA genes. Regarding to the area under the ROC curve, CNV of these genes had a high value of 0.967, which implied that CNV of the candidate genes have predictive value for identifying response to neoadjuvant chemotherapy in CRC patients. Furthermore, the Copy Number Instability (CNI) value of R group was significantly higher than NR group(p = 0.0014). Conclusions: The candidate genes’ copy number variation and CNI value of baseline plasma cfDNA can identify the colorectal cancer patients with response or without response to neoadjuvant chemotherapy in this small cohort. The molecular profile of cfDNA in plasma may be a potential biomarker for predicting the response to neoadjuvant chemotherapy in colorectal cancer patients. These findings warrant further expanded prospective cohorts to validate.

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