scholarly journals CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo

Cancer ◽  
2012 ◽  
Vol 119 (4) ◽  
pp. 729-738 ◽  
Author(s):  
Marica Gemei ◽  
Peppino Mirabelli ◽  
Rosa Di Noto ◽  
Claudia Corbo ◽  
Antonino Iaccarino ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Tumor Growth ◽  
Cell Isolation ◽  
Stem Cell Isolation

Microfluidic Tandem Mechanical Sorting System for Enhanced Cancer Stem Cell Isolation and Ingredient Screening

2021 ◽  
pp. 2100985
Author(s):  
Yuanyuan Jia ◽  
Peiliang Shen ◽  
Tao Yan ◽  
Weijia Zhou ◽  
Jia Sun ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Isolation ◽  
Sorting System ◽  
Stem Cell Isolation

scholarly journals RUNX1 suppresses breast cancer stemness and tumor growth

2018 ◽  
Author(s):  
Deli Hong ◽  
Andrew J. Fritz ◽  
Kristiaan H. Finstad ◽  
Mark P. Fitzgerald ◽  
Adam L. Viens ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Tumor Suppressor ◽  
Cancer Stem Cell ◽  
Tumor Growth ◽  
Epithelial Mesenchymal Transition ◽  
Ectopic Expression ◽  
Cell Activity ◽  
Mesenchymal Transition

SummaryRecent studies have revealed that mutations in the transcription factor Runx1 are prevalent in breast tumors. Yet, how loss of Runx1 contributes to breast cancer (BCa) remains unresolved. We demonstrate for the first time that Runx1 represses the breast cancer stem cell (BCSC) phenotype and consequently, functions as a tumor suppressor in breast cancer. Runx1 ectopic expression in MCF10AT1 and MCF10CA1a BCa cells reduces (60%) migration, invasion and in vivo tumor growth in mouse mammary fat pad (P<0.05). Runx1 is decreased in BCSCs, and overexpression of Runx1 suppresses tumorsphere formation and reduces the BCSC population. Furthermore, Runx1 inhibits Zeb1 expression, while Runx1 depletion activates Zeb1 and the epithelial-mesenchymal transition. Mechanistically Runx1 functions as a tumor suppressor in breast cancer through repression of cancer stem cell activity. This key regulation of BCSCs by Runx1 may be shared in other epithelial carcinomas, highlighting the importance of Runx1 in solid tumors.

Advancements in Cancer Stem Cell Isolation and Characterization

2019 ◽  
Vol 15 (6) ◽  
pp. 755-773 ◽  
Author(s):  
Heena Jariyal ◽  
Chanchal Gupta ◽  
Vedika Sandeep Bhat ◽  
Jayant Ramakant Wagh ◽  
Akshay Srivastava
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Isolation ◽  
Isolation And Characterization ◽  
Stem Cell Isolation

scholarly journals Extracellular vesicles from human liver stem cells inhibit renal cancer stem cell‐derived tumor growth in vitro and in vivo

2020 ◽  
Vol 147 (6) ◽  
pp. 1694-1706 ◽  
Author(s):  
Alessia Brossa ◽  
Valentina Fonsato ◽  
Cristina Grange ◽  
Stefania Tritta ◽  
Marta Tapparo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Tumor Growth ◽  
Extracellular Vesicles ◽  
Renal Cancer ◽  
Human Liver ◽  
Liver Stem Cells

Abstract 1908: The Wnt-target Prox1 promotes colorectal cancer stem cell survival to fuel tumor growth

2014 ◽  
Author(s):  
Zoltan Wiener ◽  
Ville Hyvönen ◽  
Jenny Högström ◽  
Tanja Holopainen ◽  
Arja Band ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Tumor Growth ◽  
Cell Survival ◽  
Stem Cell Survival

scholarly journals Agent-based modeling of cancer stem cell driven solid tumor growth

2015 ◽  
Author(s):  
Jan T Poleszczuk ◽  
Paul Macklin ◽  
Heiko Enderling
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Tumor Growth ◽  
Population Level ◽  
In Vitro Assays ◽  
Agent Based ◽  
In Vivo Experiments ◽  
Behavioral Rules

Computational modeling of tumor growth has become an invaluable tool to simulate complex cell-cell interactions and emerging population-level dynamics. Agent-based models are commonly used to describe the behavior and interaction of individual cells in different environments. Behavioral rules can be informed and calibrated by in vitro assays, and emerging population-level dynamics may be validated with both in vitro and in vivo experiments. Here, we describe the design and implementation of a lattice-based agent-based model of cancer stem cell driven tumor growth.

400 FAK Inhibitor VS-4718 Attenuates Breast Cancer Stem Cell Function and Inhibits Tumor Growth in Vivo

2012 ◽  
Vol 48 ◽  
pp. 122 ◽  
Author(s):  
Q. Xu ◽  
V.N. Kolev ◽  
C.M. Vidal ◽  
I.M. Shapiro ◽  
J.E. Ring ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Tumor Growth ◽  
Cell Function ◽  
Breast Cancer Stem Cell
Sign in / Sign up

Export Citation Format

Share Document