scholarly journals Excision repair cross-complementing gene-1, ribonucleotide reductase subunit M1, ribonucleotide reductase subunit M2, and human equilibrative nucleoside transporter-1 expression and prognostic value in biliary tract malignancy

Cancer ◽  
2012 ◽  
Vol 119 (2) ◽  
pp. 454-462 ◽  
Author(s):  
Sarah B. Fisher ◽  
Kevin E. Fisher ◽  
Sameer H. Patel ◽  
Matthew G. Lim ◽  
David A. Kooby ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Ribonucleotide Reductase ◽  
Prognostic Value ◽  
Excision Repair ◽  
Nucleoside Transporter ◽  
Equilibrative Nucleoside Transporter ◽  
Biliary Tract Malignancy ◽  
Ribonucleotide Reductase Subunit M2

scholarly journals RRM1 Expression as a Prognostic Biomarker for Unresectable or Recurrent Biliary Tract Cancer Treated with Gemcitabine plus Cisplatin

2021 ◽  
Vol 10 (20) ◽  
pp. 4652
Author(s):  
Jung Won Chun ◽  
Boyoung Lee ◽  
Weon Seo Park ◽  
Nayoung Han ◽  
Eun Kyung Hong ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Large Scale ◽  
Cytidine Deaminase ◽  
Progression Free Survival ◽  
Chemotherapy Response ◽  
Nucleoside Transporter ◽  
Free Survival ◽  
Equilibrative Nucleoside Transporter ◽  
Tract Cancer

The combination of gemcitabine plus cisplatin (GP) is regarded as a first-line treatment for patients with unresectable or recurrent biliary tract cancer (BTC). Several proteins including human equilibrative nucleoside transporter-1 (hENT1), deoxycytidine kinase (DCK), cytidine deaminase (CDA), and ribonucleotide reductase subunit 1 (RRM1) are known to be involved in gemcitabine uptake and metabolism. This study was aimed to identify the predictive and prognostic values of these biomarkers in patients who treated with GP for advanced BTC. Tumor samples were obtained from 34 patients with unresectable or recurrent BTC who were treated with GP between August 2015 and February 2018. Intratumoral expression of hENT1, DCK, CDA and RRM1 was determined by immunohistochemistry and analyzed for association with chemotherapy response, progression-free survival (PFS) and overall survival (OS). Median OS was significantly longer in the RRM1-negative group than in the RRM1-positive (9.9 months vs. 5.9 months, p = 0.037). Multivariate adjustment analyses also demonstrated RRM1 expression as an independent prognostic factor for OS in patients treated with GP chemotherapy. Increased intratumoral expression of RRM1 on immunohistochemical staining may be a biomarker predicting poor survival in patients with GP chemotherapy for advanced BTC. Large-scale well-predefined prospective research is needed to validate the utility of biomarkers in clinical practice.

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