scholarly journals The association of the BRAFV600E mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer

Cancer ◽  
2011 ◽  
Vol 118 (7) ◽  
pp. 1764-1773 ◽  
Author(s):  
Tae Hyuk Kim ◽  
Young Joo Park ◽  
Jung Ah Lim ◽  
Hwa Young Ahn ◽  
Eun Kyung Lee ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factors ◽  
Clinical Outcome ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Poor Clinical Outcome

scholarly journals The Risk of Relapse in Papillary Thyroid Cancer (PTC) in the Context of BRAFV600E Mutation Status and Other Prognostic Factors

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132821 ◽  
Author(s):  
Agnieszka Czarniecka ◽  
Monika Kowal ◽  
Dagmara Rusinek ◽  
Jolanta Krajewska ◽  
Michal Jarzab ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factors ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Mutation Status ◽  
Risk Of Relapse

scholarly journals BRAFV600E mutation influences hypoxia-inducible factor-1α expression levels in papillary thyroid cancer

2010 ◽  
Vol 23 (8) ◽  
pp. 1052-1060 ◽  
Author(s):  
Monica Zerilli ◽  
Giovanni Zito ◽  
Anna Martorana ◽  
Maria Pitrone ◽  
Daniela Cabibi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Hypoxia Inducible Factor ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Expression Levels ◽  
Hypoxia Inducible Factor 1Α

BRAFV600E mutation is associated with increased prevalence of contralateral lymph-node metastases in low and low-to-intermediate risk papillary thyroid cancer

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Alfredo Campennì ◽  
Rosaria M. Ruggeri ◽  
Giuseppe Giuffrè ◽  
Massimiliano Siracusa ◽  
Angela Alibrandi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Cancer ◽  
Lymph Node Metastases ◽  
Intermediate Risk ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Node Metastases

scholarly journals Correlation between F18-FDG PET/CT Imaging and BRAF V600E Genetic Mutation for the Early Assessment of Treatment Response in Papillary Thyroid Cancers

2020 ◽  
Vol 10 (2) ◽  
pp. 52
Author(s):  
Andra Piciu ◽  
Maria-Iulia Larg ◽  
Doina Piciu
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factors ◽  
Papillary Thyroid Cancer ◽  
Genetic Mutation ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Early Assessment ◽  
Pet Ct ◽  
Ct Evaluation

In thyroid neoplastic pathology, the BRAF V600E mutation is shown to be involved in the oncogenesis of papillary thyroid cancer and its subtypes. The purpose of this study is to evaluate the correlation between the mutation of the BRAF V600E oncogene and the pathological standardized uptake values (SUV) at the F18-fluorodeoxyglucose (F18-FDG) positron emission tomography/computed tomography (PET/CT) evaluation, for a group of 20 patients with radically treated (total thyroidectomy and radioiodine therapy) papillary thyroid cancer, with subclinical persistent disease, at 6 months after the initial treatment. We analyzed the correlations between the values of SUV and the presence of the BRAF mutation as well with other prognostic factors such as stage, age, specific tumor markers (thyroglobulin and anti-thyroglobulin), extrathyroid extension, the presence of metastatic lymph nodes or distant metastasis. The value of SUV in the case of BRAF+ (positive) patients was higher than in the negative ones, but without statistical significance, thus, the values of the SUV cannot be a predictable factor for the presence of the genetic mutation. There was a statistically significant correlation in BRAF+ subgroup between the SUV values and the positive resection limit following surgery, showing a higher SUV value in the PET/CT evaluation. No correlation was observed between the aforementioned prognostic factors involved in papillary thyroid cancer and the BRAF V600E mutation.

scholarly journals Clinical Responses to Vemurafenib in Patients with Metastatic Papillary Thyroid Cancer Harboring BRAFV600E Mutation

Thyroid ◽  
2013 ◽  
Vol 23 (10) ◽  
pp. 1277-1283 ◽  
Author(s):  
Kevin B. Kim ◽  
Maria E. Cabanillas ◽  
Alexander J. Lazar ◽  
Michelle D. Williams ◽  
Deborah L. Sanders ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Clinical Responses

BRAFV600E Mutation and Papillary Thyroid Cancer

JAMA ◽  
2013 ◽  
Vol 310 (5) ◽  
pp. 534 ◽  
Author(s):  
Alessia Ciarrocchi ◽  
Silvio Cavuto ◽  
Simonetta Piana
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Brafv600e Mutation

BRAFV600E Mutation is Associated with Decreased Disease-Free Survival in Papillary Thyroid Cancer

2016 ◽  
Vol 40 (7) ◽  
pp. 1618-1624 ◽  
Author(s):  
S. Fraser ◽  
C. Go ◽  
A. Aniss ◽  
S. Sidhu ◽  
L. Delbridge ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Disease Free Survival ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Free Survival ◽  
Disease Free
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