The prognostic and staging implications of bone invasion in oral squamous cell carcinoma

Cancer ◽  
2011 ◽  
Vol 117 (19) ◽  
pp. 4460-4467 ◽  
Author(s):  
Ardalan Ebrahimi ◽  
Rajmohan Murali ◽  
Kan Gao ◽  
Michael S. Elliott ◽  
Jonathan R. Clark
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bone Invasion

Bone invasion by oral squamous cell carcinoma

2021 ◽  
Vol 63 (3) ◽  
Author(s):  
David Král ◽  
Richard Pink ◽  
Lenka Šašková ◽  
Jaroslav Michálek ◽  
Peter Tvrdý
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bone Invasion

scholarly journals CCL28-induced RARβ expression inhibits oral squamous cell carcinoma bone invasion

2019 ◽  
Vol 129 (12) ◽  
pp. 5381-5399 ◽  
Author(s):  
Junhee Park ◽  
Xianglan Zhang ◽  
Sun Kyoung Lee ◽  
Na-Young Song ◽  
Seung Hwa Son ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bone Invasion

scholarly journals The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yin-Zhe An ◽  
Eunae Cho ◽  
Junqi Ling ◽  
Xianglan Zhang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cancer Associated Fibroblasts ◽  
Bone Invasion ◽  
Biological Behaviour ◽  
Snail Expression

Abstract Background In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. Methods The clinicopathological significance of Axin2 and Snail expression was investigated by immunohistochemistry in an OSCC cohort containing 217 tissue samples from patients with long-term follow-up. The influence of the Axin2-Snail axis on the biological behaviour of OSCC cells and CAFs was further investigated both in vitro and in vivo. Results Axin2 expression was significantly associated with Snail expression, the desmoplasia status, and bone invasion in patients with OSCC. In multivariate analysis, lymph node metastasis, desmoplasia, Axin2 expression, and Snail expression were independent poor prognostic factors in our cohort. Consistent with these findings, OSCC cells demonstrated attenuated oncogenic activity as well as decreased expression of Snail and various cytokines after Axin2 knockdown in vitro. Among the related cytokines, C-C motif chemokine ligand 5 (CCL5) and interleukin 8 (IL8) demonstrated a strong influence on the biological behaviour of CAFs in vitro. Moreover, both the desmoplastic reaction and osteolytic lesions in the calvaria were predominantly decreased after Axin2 knockdown in OSCC cells in vivo using a BALB/c athymic nude mouse xenograft model. Conclusions Oncogenic activities of the Axin2-Snail axis are not limited to the cancer cells themselves but rather extend to CAFs via regulation of the cytokine-mediated cancer-stromal interaction, with further implications for bone invasion as well as a poor prognosis in OSCC.

scholarly journals Establishment of a murine model of bone invasion by oral squamous cell carcinoma

Oral Oncology ◽  
2007 ◽  
Vol 43 (3) ◽  
pp. 257-262 ◽  
Author(s):  
Takeshi Nomura ◽  
Takahiko Shibahara ◽  
Akira Katakura ◽  
Shizuka Matsubara ◽  
Nobuo Takano
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Murine Model ◽  
Bone Invasion

The cellular and molecular mechanisms of bone invasion by oral squamous cell carcinoma

Oral Diseases ◽  
2010 ◽  
Vol 17 (5) ◽  
pp. 462-468 ◽  
Author(s):  
E Jimi ◽  
H Furuta ◽  
K Matsuo ◽  
K Tominaga ◽  
T Takahashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Molecular Mechanisms ◽  
Bone Invasion

p130Cas induces bone invasion by oral squamous cell carcinoma by regulating tumor epithelial–mesenchymal transition and cell proliferation

2020 ◽  
Vol 41 (8) ◽  
pp. 1038-1048
Author(s):  
Tatsuki Yaginuma ◽  
Jing Gao ◽  
Kengo Nagata ◽  
Ryusuke Muroya ◽  
Huang Fei ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Bone Matrix ◽  
Bone Invasion ◽  
Mesenchymal Transition ◽  
Tgf Β1

Abstract Bone invasion is a critical factor in determining the prognosis of oral squamous cell carcinoma (OSCC) patients. Transforming growth factor β (TGF-β) is abundantly expressed in the bone matrix and is involved in the acquisition of aggressiveness by tumors. TGF-β is also important to cytoskeletal changes during tumor progression. In this study, we examined the relationship between TGF-β signaling and cytoskeletal changes during bone invasion by OSCC. Immunohistochemical staining of OSCC samples from five patients showed the expression of p130Cas (Crk-associated substrate) in the cytoplasm and phosphorylated Smad3 expression in the nucleus in OSCC cells. TGF-β1 induced the phosphorylation of Smad3 and p130Cas, as well as epithelial–mesenchymal transition (EMT) accompanied by the downregulation of the expression of E-cadherin, a marker of epithelial cells, and the upregulation of the expression of N-cadherin, or Snail, a marker of mesenchymal cells, in human HSC-2 cells and mouse squamous cell carcinome VII (SCCVII) cells. SB431542, a specific inhibitor of Smad2/3 signaling, abrogated the TGF-β1-induced phosphorylation of p130Cas and morphological changes. Silencing p130Cas using an short hairpin RNA (shRNA) or small interfering RNA in SCCVII cells suppressed TGF-β1-induced cell migration, invasion, EMT and matrix metalloproteinase-9 (MMP-9) production. Compared with control SCCVII cells, SCCVII cells with silenced p130Cas strongly suppressed zygomatic and mandibular destruction in vivo by reducing the number of osteoclasts, cell proliferation and MMP-9 production. Taken together, these results showed that the expression of TGF-β/p130Cas might be a new target for the treatment of OSCC bone invasion.

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