Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT

Cancer ◽  
2011 ◽  
Vol 117 (18) ◽  
pp. 4141-4154 ◽  
Author(s):  
Bernhard Svejda ◽  
Mark Kidd ◽  
Alexander Kazberouk ◽  
Ben Lawrence ◽  
Roswitha Pfragner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Neuroendocrine Tumor ◽  
Feedback Loop ◽  
Tumor Therapy ◽  
Kinase Inhibition ◽  
Mtor Kinase ◽  
Small Intestinal ◽  
Loop Activation

scholarly journals HIF-mediated Suppression of DEPTOR Confers Resistance to mTOR Kinase Inhibition in Renal Cancer

iScience ◽  
2019 ◽  
Vol 21 ◽  
pp. 509-520 ◽  
Author(s):  
Hong Doan ◽  
Alexander Parsons ◽  
Shruthi Devkumar ◽  
Jogitha Selvarajah ◽  
Francesc Miralles ◽  
...  
Keyword(s):  
Renal Cancer ◽  
Kinase Inhibition ◽  
Mtor Kinase

scholarly journals Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats

2004 ◽  
Vol 66 (5) ◽  
pp. 1766-1773 ◽  
Author(s):  
Vicente E. Torres ◽  
William E. Sweeney ◽  
Xiaofang Wang ◽  
Q.I. Qian ◽  
Peter C. Harris ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Growth Factor Receptor ◽  
Kinase Inhibition ◽  
Tyrosine Kinase Inhibition ◽  
Epidermal Growth

The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer

2002 ◽  
Vol 50 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Rachel Gibson ◽  
Dorothy Keefe ◽  
Julie Clarke ◽  
Geoff Regester ◽  
Fiona Thompson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Tumour Growth ◽  
Keratinocyte Growth Factor ◽  
Intestinal Mucositis ◽  
Small Intestinal

scholarly journals Anti-SSTR2 antibody-drug conjugate for neuroendocrine tumor therapy

2020 ◽  
Author(s):  
Yingnan Si ◽  
Seulhee Kim ◽  
Jianfa Ou ◽  
Yun Lu ◽  
Patrick Ernst ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Tumor Therapy ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals Disruption of TP63-miR-27a* Feedback Loop by Mutant TP53 in Head and Neck Cancer

2019 ◽  
Vol 112 (3) ◽  
pp. 266-277 ◽  
Author(s):  
Nikhil S Chari ◽  
Cristina Ivan ◽  
Xiandong Le ◽  
Jinzhong Li ◽  
Ainiwaer Mijiti ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Oral Cavity ◽  
Head And Neck ◽  
Feedback Loop ◽  
Growth Factor Receptor ◽  
Epidermal Growth

Abstract Background Alterations in the epidermal growth factor receptor and PI3K pathways in head and neck squamous cell carcinomas (HNSCCs) are frequent events that promote tumor progression. Ectopic expression of the epidermal growth factor receptor–targeting microRNA (miR), miR-27a* (miR-27a-5p), inhibits tumor growth. We sought to identify mechanisms mediating repression of miR-27a* in HNSCC, which have not been previously identified. Methods We quantified miR-27a* in 47 oral cavity squamous cell carcinoma patient samples along with analysis of miR-27a* in 73 oropharyngeal and 66 human papillomavirus–positive (HPV+) samples from The Cancer Genome Atlas. In vivo and in vitro TP53 models engineered to express mutant TP53, along with promoter analysis using chromatin immunoprecipitation and luciferase assays, were used to identify the role of TP53 and TP63 in miR-27a* transcription. An HNSCC cell line engineered to conditionally express miR-27a* was used in vitro to determine effects of miR-27a* on target genes and tumor cells. Results miR-27a* expression was repressed in 47 oral cavity tumor samples vs matched normal tissue (mean log2 difference = −0.023, 95% confidence interval = −0.044 to −0.002; two-sided paired t test, P = .03), and low miR-27a* levels were associated with poor survival in HPV+ and oropharyngeal HNSCC samples. Binding of ΔNp63α to the promoter led to an upregulation of miR-27a*. In vitro and in vivo findings showed that mutant TP53 represses the miR-27a* promoter, downregulating miR-27a* levels. ΔNp63α and nucleoporin 62, a protein involved in ΔNP63α transport, were validated as novel targets of miR-27a*. Conclusion Our results characterize a negative feedback loop between TP63 and miR-27a*. Genetic alterations in TP53, a frequent event in HNSCC, disrupt this regulatory loop by repressing miR-27a* expression, promoting tumor survival.

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