scholarly journals DICKKOPF-4 activates the noncanonical c-Jun-NH2 kinase signaling pathway while inhibiting the Wnt-canonical pathway in human renal cell carcinoma

Cancer ◽  
2010 ◽  
Vol 117 (8) ◽  
pp. 1649-1660 ◽  
Author(s):  
Hiroshi Hirata ◽  
Yuji Hinoda ◽  
Shahana Majid ◽  
Yi Chen ◽  
Mohd S. Zaman ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Renal Cell ◽  
Canonical Pathway ◽  
Kinase Signaling ◽  
Human Renal Cell Carcinoma ◽  
Kinase Signaling Pathway

Oleic acid promotes cell invasion through an integrin-linked kinase signaling pathway in renal cell carcinoma

2019 ◽  
Vol 72 (6) ◽  
pp. 968-975 ◽  
Author(s):  
Zhen-Hua Liu ◽  
Cai-Peng Qing ◽  
Zheng-Zuo Sheng ◽  
Gui-Zhong Li ◽  
Li-Bo Man ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Oleic Acid ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Cell Invasion ◽  
Renal Cell ◽  
Kinase Signaling ◽  
Integrin Linked Kinase ◽  
Kinase Signaling Pathway

108 IGFBP-4 ACTIVATES THE WNT/BETA-CATENIN SIGNALING PATHWAY AND INDUCES M-CAM EXPRESSION IN HUMAN RENAL CELL CARCINOMA

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Koji Ueno ◽  
Hiroshi Hirata ◽  
Z. Laura Tabatabai ◽  
Yuji Hinoda ◽  
Peter R. Carroll ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Renal Cell ◽  
Beta Catenin ◽  
Human Renal Cell Carcinoma

scholarly journals Rap2B promotes angiogenesis via PI3K/AKT/VEGF signaling pathway in human renal cell carcinoma

Tumor Biology ◽  
2017 ◽  
Vol 39 (7) ◽  
pp. 101042831770165 ◽  
Author(s):  
Jiehui Di ◽  
Keyu Gao ◽  
Debao Qu ◽  
Yaoyao Wu ◽  
Jing Yang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Renal Cell ◽  
Human Renal Cell Carcinoma ◽  
Vegf Signaling ◽  
Vegf Signaling Pathway

scholarly journals MicroRNA-21 Regulates the Proliferation, Differentiation, and Apoptosis of Human Renal Cell Carcinoma Cells by the mTOR-STAT3 Signaling Pathway

2016 ◽  
Vol 24 (5) ◽  
pp. 371-380 ◽  
Author(s):  
Tao Liang ◽  
Xiao-Yong Hu ◽  
Yong-Hui Li ◽  
Bin-Qiang Tian ◽  
Zuo-Wei Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Mrna Expression ◽  
Signaling Pathway ◽  
Renal Cell ◽  
Caspase 3 ◽  
Human Renal Cell Carcinoma ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

MicroRNA-21 (miRNA-21), a kind of short, noncoding RNAs, functioned as a tumor marker and was upregulated in renal cell carcinoma (RCC). However, the underlying mechanisms of miRNA-21 in RCC were uncertain. Therefore, the effects and mechanisms of miRNA-21 on the proliferation, differentiation, and apoptosis of cultured human RCC cells were further investigated in this study. After slicing miRNA-21 in RCC cells, the viability, mRNA expression of C/EBPα and PPARγ, caspase 3 activity, and protein expression of mTOR, STAT3, and pSTAT3 were determined. It was found that knockdown of miRNA-21 downregulated the optical density (OD) value of cells, inhibited mRNA expression of PPARγ and C/EBPα, and enhanced activity of caspase 3. Furthermore, protein expression of pSTAT3 was also decreased in the absence of miRNA-21. Notably, miRNA-21-changed proliferation, differentiation, and apoptosis of human RCC cells were partially regulated following the block of the mTOR-STAT3 signaling pathway by the mTOR inhibitor (XL388). It was indicated that miRNA-21 promoted proliferation and differentiation and decreased apoptosis of human RCC cells through the activation of the mTOR-STAT3 signaling pathway.

scholarly journals Alterations in Janus (JAK2)/signal transducer of activated transcription signaling pathway in human renal cell carcinoma (1179.2)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Amy Banes‐Berceli ◽  
Sara Singhal ◽  
Matthew Fulton ◽  
Timothy Geddes ◽  
Bryan Thibodeau ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Renal Cell ◽  
Signal Transducer ◽  
Human Renal Cell Carcinoma
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