scholarly journals Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: Is there a difference in outcome between morning and afternoon treatment?

Cancer ◽  
2010 ◽  
Vol 117 (2) ◽  
pp. 414-420 ◽  
Author(s):  
Douglas A. Rahn ◽  
Dibyendu K. Ray ◽  
David J. Schlesinger ◽  
Ladislau Steiner ◽  
Jason P. Sheehan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastasis ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Gamma Knife Radiosurgery ◽  
Nonsmall Cell Lung Cancer

scholarly journals Long-Term Survival of a Patient with Brainstem and Recurrent Brain Metastasis from Stage IV Nonsmall Cell Lung Cancer Treated with Multiple Gamma Knife Radiosurgeries and Craniotomies: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Andrew F. Lamm ◽  
Ameer L. Elaimy ◽  
Alexander R. Mackay ◽  
Robert K. Fairbanks ◽  
John J. Demakas ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastasis ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Gamma Knife Radiosurgery ◽  
Stage Iv ◽  
Nonsmall Cell Lung Cancer ◽  
Term Survival ◽  
The Right

The prognosis of patients diagnosed with stage IV nonsmall cell lung cancer that have brain and brainstem metastasis is very poor, with less than a third surviving a year past their initial date of diagnosis. We present the rare case of a 57-year-old man who is a long-term survivor of brainstem and recurrent brain metastasis, after aggressive treatment. He is now five and a half years out from diagnosis and continues to live a highly functional life without evidence of disease. Four separate Gamma Knife stereotactic radiosurgeries in conjunction with two craniotomies were utilized since his initial diagnosis to treat recurrent brain metastasis while chemoradiation therapy and thoracic surgery were used to treat his primary disease in the right upper lung. In his situation, Gamma Knife radiosurgery proved to be a valuable, safe, and effective tool for the treatment of multiply recurrent brain metastases within critical normal structures.

scholarly journals Pulmonary resection in patients with nonsmall-cell lung cancer treated with gamma-knife radiosurgery for synchronous brain metastases

Cancer ◽  
2008 ◽  
Vol 112 (8) ◽  
pp. 1780-1786 ◽  
Author(s):  
Seung-Yeob Yang ◽  
Dong Gyu Kim ◽  
Se-Hoon Lee ◽  
Hyun-Tai Chung ◽  
Sun Ha Paek ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Pulmonary Resection ◽  
Gamma Knife Radiosurgery ◽  
Nonsmall Cell Lung Cancer

Gamma Knife Radiosurgery for Treatment of Cerebral Metastases From Non–Small-Cell Lung Cancer

2011 ◽  
Vol 81 (4) ◽  
pp. e463-e468 ◽  
Author(s):  
Micaela Motta ◽  
Antonella del Vecchio ◽  
Luca Attuati ◽  
Piero Picozzi ◽  
Lucia. Perna ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Cerebral Metastases ◽  
Small Cell Lung

scholarly journals Prognosis of Non-Small Cell Lung Cancer with Synchronous Brain Metastases Treated with Gamma Knife Radiosurgery

2006 ◽  
Vol 21 (3) ◽  
pp. 527 ◽  
Author(s):  
Doo-Sik Kong ◽  
Jung-Il Lee ◽  
Do Hyun Nam ◽  
Kwan Park ◽  
Jong Hyun Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Gamma Knife Radiosurgery for Brain Metastases in Non-Small Cell Lung Cancer Patients Treated with Immunotherapy or Targeted Therapy

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3668
Author(s):  
Anna Cho ◽  
Helena Untersteiner ◽  
Dorian Hirschmann ◽  
Abdallah Shaltout ◽  
Philipp Göbl ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Combined Treatment ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Small Cell Lung

The combination of Gamma Knife radiosurgery (GKRS) and systemic immunotherapy (IT) or targeted therapy (TT) is a novel treatment method for brain metastases (BMs) in non-small cell lung cancer (NSCLC). To elucidate the safety and efficacy of concomitant IT or TT on the outcome after GKRS, 496 NSCLC patients with BMs, who were treated with GKRS were retrospectively reviewed. The median time between the initial lung cancer diagnosis and the diagnosis of brain metastases was one month. The survival after the initial BM diagnosis was significantly longer than the survival predicted by prognostic BM scores. After the first Gamma Knife radiosurgery treatment (GKRS1), the estimated median survival was 9.9 months (95% CI = 8.3–11.4). Patients with concurrent IT or TT presented with a significantly longer survival after GKRS1 than patients without IT or TT (p < 0.001). These significant differences in the survival were also apparent among the four treatment groups and remained significant after adjustment for Karnofsky performance status scale (KPS), recursive partitioning analysis (RPA) class, sex, and multiple BMs. About half of all our patients (46%) developed new distant BMs after GKRS1. Of note, no statistically significant differences in the occurrence of radiation reaction, radiation necrosis, or intralesional hemorrhage in association with IT or TT at or after GKRS1 were observed. In NSCLC-BM patients, the concomitant use of GKRS and IT or TT showed an increase in overall survival without increased complications related to GKRS. Therefore, the combined treatment with GKRS and IT or TT seems to be a safe and powerful treatment option and emphasizes the role of radiosurgery in modern BM treatment.

Treatment outcome for patients with primary nonsmall-cell lung cancer and synchronous brain metastasis

1999 ◽  
Vol 7 (5) ◽  
pp. 313-319 ◽  
Author(s):  
Mark A. Chidel ◽  
John H. Suh ◽  
John F. Greskovich ◽  
Patrick A. Kupelian ◽  
Gene H. Barnett
Keyword(s):  
Lung Cancer ◽  
Treatment Outcome ◽  
Brain Metastasis ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer

scholarly journals Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF)

Neurosurgery ◽  
2021 ◽  
Vol 89 (Supplement_2) ◽  
pp. S20-S20
Author(s):  
Christopher P Cifarelli ◽  
John A Vargo ◽  
Wei Fang ◽  
Roman Liscak ◽  
Khumar Guseynova ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Retrospective Study ◽  
Small Cell Lung Cancer ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Small Cell Lung
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