scholarly journals The influence of proteasome inhibitor MG132, external radiation, and unlabeled antibody on the tumor uptake and biodistribution of 188Re-labeled anti-E6 C1P5 antibody in cervical cancer in mice

Cancer ◽  
2010 ◽  
Vol 116 (S4) ◽  
pp. 1067-1074 ◽  
Author(s):  
Rébécca Phaeton ◽  
Xing Guo Wang ◽  
Mark H. Einstein ◽  
Gary L. Goldberg ◽  
Arturo Casadevall ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Proteasome Inhibitor ◽  
Proteasome Inhibitor Mg132 ◽  
Tumor Uptake ◽  
External Radiation ◽  
Unlabeled Antibody

scholarly journals Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis

2005 ◽  
Vol 118 (8) ◽  
pp. 1892-1900 ◽  
Author(s):  
Brigitte M.T. Hougardy ◽  
John H. Maduro ◽  
Ate G.J. van der Zee ◽  
Derk Jan A. de Groot ◽  
Fiona A.J. van den Heuvel ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Proteasome Inhibitor ◽  
Proteasome Inhibitor Mg132 ◽  
Cervical Cancer Cells ◽  
Induced Apoptosis ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer

The proteasome inhibitor MG132 induces apoptosis in human pancreatic cancer cells

2005 ◽  
Author(s):  
Moritz Wente ◽  
Guido Eibl ◽  
Howard Reber ◽  
Helmut Friess ◽  
Markus Büchler ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Proteasome Inhibitor ◽  
Human Pancreatic Cancer ◽  
Proteasome Inhibitor Mg132 ◽  
Pancreatic Cancer Cells

scholarly journals Over-Activated Proteasome Mediates Neuroinflammation on Acute Intracerebral Hemorrhage in Rats

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1326 ◽  
Author(s):  
Hock-Kean Liew ◽  
Wei-Fen Hu ◽  
Peter Bor-Chian Lin ◽  
Po-Kai Wang ◽  
Andy Po-Yi Tsai ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Er Stress ◽  
Inflammatory Cytokines ◽  
Proteasome Inhibitor ◽  
Neuronal Cell ◽  
Neurological Deficits ◽  
Critical Event ◽  
Secondary Brain Injury ◽  
Proteasome Inhibitor Mg132 ◽  
Pro Inflammatory Cytokines

Background: Neuroinflammation is a hallmark in intracerebral hemorrhage (ICH) that induces secondary brain injury, leading to neuronal cell death. ER stress-triggered apoptosis and proteostasis disruption caused neuroinflammation to play an important role in various neurological disorders. The consequences of ER stress and proteostasis disruption have rarely been studied during the course of ICH development. Methods: ICH was induced by collagenase VII-S intrastriatal infusion. Animals were sacrificed at 0, 3, 6, 24, and 72 h post-ICH. Rats were determined for body weight changes, hematoma volume, and neurological deficits. Brain tissues were harvested for molecular signaling analysis either for ELISA, immunoblotting, immunoprecipitation, RT-qPCR, protein aggregation, or for histological examination. A non-selective proteasome inhibitor, MG132, was administered into the right striatum three hours prior to ICH induction. Results: ICH-induced acute proteasome over-activation caused the early degradation of the endoplasmic reticulum (ER) chaperone GRP78 and IκB protein. These exacerbations were accompanied by the elevation of pro-apoptotic CCAAT-enhancer-binding protein homologous protein (CHOP) and pro-inflammatory cytokines expression via nuclear factor-kappa B (NF-κB) signal activation. Pre-treatment with proteasome inhibitor MG132 significantly ameliorated the ICH-induced ER stress/proteostasis disruption, pro-inflammatory cytokines, neuronal cells apoptosis, and neurological deficits. Conclusions: ICH induced rapid proteasome over-activation, leading to an exaggeration of the ER stress/proteostasis disruption, and neuroinflammation might be a critical event in acute ICH pathology.

Proteasome inhibitor MG132 modulates inflammatory pain by central mechanisms in adjuvant arthritis

2014 ◽  
Vol 20 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Aisha Siddiqah Ahmed ◽  
Mahmood Ahmed ◽  
Jian Li ◽  
Harvest F. Gu ◽  
Georgy Bakalkin ◽  
...  
Keyword(s):  
Inflammatory Pain ◽  
Adjuvant Arthritis ◽  
Proteasome Inhibitor ◽  
Proteasome Inhibitor Mg132
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