Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol

Cancer ◽  
2010 ◽  
Vol 116 (3) ◽  
pp. 705-712 ◽  
Author(s):  
Johannes E.A. Wolff ◽  
Pablo Hernaiz Driever ◽  
Bernhard Erdlenbruch ◽  
Rolf D. Kortmann ◽  
Stefan Rutkowski ◽  
...  
Keyword(s):  
High Grade Glioma ◽  
Gross Total Resection ◽  
High Grade ◽  
Intensive Chemotherapy ◽  
Total Resection ◽  
Pediatric High Grade Glioma

scholarly journals Characteristics of Fluorescent Intraoperative Dyes Helpful in Gross Total Resection of High-Grade Gliomas—A Systematic Review

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1100
Author(s):  
Marek Mazurek ◽  
Bartłomiej Kulesza ◽  
Filip Stoma ◽  
Jacek Osuchowski ◽  
Sławomir Mańdziuk ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Aminolevulinic Acid ◽  
High Grade Glioma ◽  
Light Filter ◽  
Gross Total Resection ◽  
High Grade ◽  
Total Resection ◽  
Glioma Surgery ◽  
Glioma Resection ◽  
Intraoperative Fluorescence

Background: A very important aspect in the treatment of high-grade glioma is gross total resection to reduce the risk of tumor recurrence. One of the methods to facilitate this task is intraoperative fluorescence navigation. The aim of the study was to compare the dyes used in this technique fluorescent intraoperative navigation in terms of the mechanism of action and influence on the treatment of patients. Methods: The review was carried out on the basis of articles found in PubMed, Google Scholar, and BMC search engines, as well as those identified by searched bibliographies and suggested by experts during the preparation of the article. The database analysis was performed for the following phrases: “glioma”, “glioblastoma”, “ALA”, “5ALA”, “5-ALA”, “aminolevulinic acid”, ”levulinic acid”, “fluorescein”, “ICG”, “indocyanine green”, and “fluorescence navigation”. Results: After analyzing 913 citations identified on the basis of the search criteria, we included 36 studies in the review. On the basis of the analyzed articles, we found that 5-aminolevulinic acid and fluorescein are highly effective in improving the percentage of gross total resection achieved in high-grade glioma surgery. At the same time, the limitations resulting from the use of these methods are marked—higher costs of the procedure and the need to have neurosurgical microscope in combination with a special light filter in the case of 5-aminolevulinic acid (5-ALA), and low specificity for neoplastic cells and the dependence on the degree of damage to the blood–brain barrier in the intensity of fluorescence in the case of fluorescein. The use of indocyanine green in the visualization of glioma cells is relatively unknown, but some researchers have suggested its utility and the benefits of using it simultaneously with other dyes. Conclusion: The use of intraoperative fluorescence navigation with the use of 5-aminolevulinic acid and fluorescein allows the range of high-grade glioma resection to be increased.

scholarly journals Biopsy versus partial versus gross total resection in older patients with high-grade glioma: a systematic review and meta-analysis

2015 ◽  
Vol 17 (6) ◽  
pp. 868-881 ◽  
Author(s):  
S. A. Almenawer ◽  
J. H. Badhiwala ◽  
W. Alhazzani ◽  
J. Greenspoon ◽  
F. Farrokhyar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Patients ◽  
Meta Analysis ◽  
High Grade Glioma ◽  
Gross Total Resection ◽  
High Grade ◽  
Total Resection

scholarly journals Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor

2017 ◽  
Vol 20 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Erin N. Kiehna ◽  
Maxine R. Arnush ◽  
Benita Tamrazi ◽  
Jennifer A. Cotter ◽  
Debra Hawes ◽  
...  
Keyword(s):  
High Grade Glioma ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
High Grade ◽  
Total Resection ◽  
Hematopoietic Stem ◽  
Stem Cell Rescue ◽  
First Case ◽  
Disease Free ◽  
Pediatric High Grade Glioma

Pediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chemotherapy and autologous hematopoietic stem cell rescue. At 30 months after transplantation, she remains disease free.

scholarly journals HG-10 * HYPOXIA PATHWAY DRIVEN BY HIF-1ALPHA ARE PREDOMINANTLY INVOLVED IN PEDIATRIC HIGH GRADE GLIOMA AND REPRESENT PROMISING THERAPEUTIC TARGETS

2015 ◽  
Vol 17 (suppl 3) ◽  
pp. iii12-iii12
Author(s):  
C. Lasthaus ◽  
M. Litzler ◽  
C. Bour ◽  
D. Guenot ◽  
N. Entz-Werle
Keyword(s):  
Therapeutic Targets ◽  
High Grade Glioma ◽  
High Grade ◽  
Pediatric High Grade Glioma

scholarly journals HGG-41. STRUCTURAL VARIANT DRIVERS IN PEDIATRIC HIGH-GRADE GLIOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii351-iii351
Author(s):  
Frank Dubois ◽  
Ofer Shapira ◽  
Noah Greenwald ◽  
Travis Zack ◽  
Jessica W Tsai ◽  
...  
Keyword(s):  
Copy Number ◽  
High Grade Glioma ◽  
High Grade ◽  
Structural Variants ◽  
Single Nucleotide Variants ◽  
Single Nucleotide ◽  
Effector Domains ◽  
Topologically Associating Domains ◽  
Genome Wide ◽  
Pediatric High Grade Glioma

Abstract BACKGROUND Driver single nucleotide variants (SNV) and somatic copy number aberrations (SCNA) of pediatric high-grade glioma (pHGGs), including Diffuse Midline Gliomas (DMGs) are characterized. However, structural variants (SVs) in pHGGs and the mechanisms through which they contribute to glioma formation have not been systematically analyzed genome-wide. METHODS Using SvABA for SVs as well as the latest pipelines for SCNAs and SNVs we analyzed whole-genome sequencing from 174 patients. This includes 60 previously unpublished samples, 43 of which are DMGs. Signature analysis allowed us to define pHGG groups with shared SV characteristics. Significantly recurring SV breakpoints and juxtapositions were identified with algorithms we recently developed and the findings were correlated with RNAseq and H3K27ac ChIPseq. RESULTS The SV characteristics in pHGG showed three groups defined by either complex, intermediate or simple signature activities. These associated with distinct combinations of known driver oncogenes. Our statistical analysis revealed recurring SVs in the topologically associating domains of MYCN, MYC, EGFR, PDGFRA & MET. These correlated with increased mRNA expression and amplification of H3K27ac peaks. Complex recurring amplifications showed characteristics of extrachromosomal amplicons and were enriched in coding SVs splitting protein regulatory from effector domains. Integrative analysis of all SCNAs, SNVs & SVs revealed patterns of characteristic combinations between potential drivers and signatures. This included two distinct groups of H3K27M DMGs with either complex or simple signatures and different combinations of associated variants. CONCLUSION Recurrent SVs associate with signatures shaped by an underlying process, which can lead to distinct mechanisms to activate the same oncogene.

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