scholarly journals The calcium-sensing receptor and parathyroid hormone-related protein are expressed in differentiated, favorable neuroblastic tumors

Cancer ◽  
2009 ◽  
Vol 115 (12) ◽  
pp. 2792-2803 ◽  
Author(s):  
Carmen de Torres ◽  
Helena Beleta ◽  
Rubén Díaz ◽  
Núria Toran ◽  
Eva Rodríguez ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Related Protein ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Parathyroid Hormone Related Protein ◽  
Neuroblastic Tumors

scholarly journals Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone–Related Protein

2016 ◽  
Vol 76 (18) ◽  
pp. 5348-5360 ◽  
Author(s):  
Wonnam Kim ◽  
Farzin M. Takyar ◽  
Karena Swan ◽  
Jaekwang Jeong ◽  
Joshua VanHouten ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Parathyroid Hormone ◽  
Related Protein ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Parathyroid Hormone Related Protein

scholarly journals Calcium stimulates parathyroid hormone-related protein production in Leydig tumor cells through a putative cation-sensing mechanism

2000 ◽  
pp. 500-505 ◽  
Author(s):  
N Buchs ◽  
D Manen ◽  
JP Bonjour ◽  
R Rizzoli
Keyword(s):  
Parathyroid Hormone ◽  
Cell Membrane ◽  
Tumor Cells ◽  
Dependent Manner ◽  
Related Protein ◽  
Sensing Mechanism ◽  
Calcium Sensing ◽  
Parathyroid Hormone Related Protein ◽  
Leydig Tumor Cells ◽  
Cation Sensing

The production of parathyroid hormone-related protein (PTHrP) is regulated by a variety of hormones and growth factors. Previous research has shown that several PTHrP-producing cells are influenced by extracellular calcium (Ca(2+)(o)) concentration, with elevated levels increasing PTH-like activity released by cultured H500 rat Leydig tumor cells through a post-transcriptional mechanism. We have investigated the hypothesis that calcium stimulates PTHrP production in H500 cells by interacting with a cell membrane-associated cation-sensing receptor. Besides increased Ca(2+)(o) concentration, magnesium and the polycationic antibiotic neomycin also increased PTHrP production in a concentration-dependent manner. In the presence of the calcium ionophore, ionomycin, which markedly elevated cytosolic free calcium, the stimulation by Ca(2+)(o) of PTHrP could still be detected. These results indicate that increasing Ca(2+)(o) stimulates PTHrP production, possibly through a putative cell membrane-associated calcium-sensing mechanism. RT-PCR revealed the presence of a very small amount of calcium-sensing receptor coding mRNA.

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