scholarly journals Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines

Cancer ◽  
2008 ◽  
Vol 113 (4) ◽  
pp. 690-700 ◽  
Author(s):  
Mark Kidd ◽  
Ignat Drozdov ◽  
Richard Joseph ◽  
Roswitha Pfragner ◽  
Michael Culler ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Neuroendocrine Tumor ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Small Intestinal

scholarly journals A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines

2012 ◽  
Vol 40 ◽  
pp. 108-113 ◽  
Author(s):  
Gert Schwach ◽  
Patchanita Thamyongkit ◽  
Lorenz Michael Reith ◽  
Bernhard Svejda ◽  
Günther Knör ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Neuroendocrine Tumor ◽  
Cell Lines ◽  
Water Soluble ◽  
Tumor Cell Lines ◽  
Cationic Porphyrin

scholarly journals A Comprehensive Molecular Characterization of the Pancreatic Neuroendocrine Tumor Cell Lines BON-1 and QGP-1

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 691 ◽  
Author(s):  
Kim B. Luley ◽  
Shauni B. Biedermann ◽  
Axel Künstner ◽  
Hauke Busch ◽  
Sören Franzenburg ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Neuroendocrine Tumor ◽  
Molecular Characterization ◽  
Cell Lines ◽  
Cell Function ◽  
Tumor Cell Lines ◽  
Β Cells ◽  
Mesenchymal Transition ◽  
Endocrine Progenitors

Experimental models of neuroendocrine tumor disease are scarce, with only a few existing neuroendocrine tumor cell lines of pancreatic origin (panNET). Their molecular characterization has so far focused on the neuroendocrine phenotype and cancer-related mutations, while a transcription-based assessment of their developmental origin and malignant potential is lacking. In this study, we performed immunoblotting and qPCR analysis of neuroendocrine, epithelial, developmental endocrine-related genes as well as next-generation sequencing (NGS) analysis of microRNAs (miRs) on three panNET cell lines, BON-1, QGP-1, and NT-3. All three lines displayed a neuroendocrine and epithelial phenotype; however, while insulinoma-derived NT-3 cells preferentially expressed markers of mature functional pancreatic β-cells (i.e., INS, MAFA), both BON-1 and QGP-1 displayed high expression of genes associated with immature or non-functional β/δ-cells genes (i.e., NEUROG3), or pancreatic endocrine progenitors (i.e., FOXA2). NGS-based identification of miRs in BON-1 and QGP-1 cells revealed the presence of all six members of the miR-17–92 cluster, which have been implicated in β-cell function and differentiation, but also have roles in cancer being both oncogenic or tumor suppressive. Notably, both BON-1 and QGP-1 cells expressed several miRs known to be negatively associated with epithelial–mesenchymal transition, invasion or metastasis. Moreover, both cell lines failed to exhibit migratory activity in vitro. Taken together, NT-3 cells resemble mature functional β-cells, while both BON-1 and QGP-1 are more similar to immature/non-functional pancreatic β/δ-cells or pancreatic endocrine progenitors. Based on the recent identification of three transcriptional subtypes in panNETs, NT-3 cells resemble the “islet/insulinoma tumors” (IT) subtype, while BON-1 and QGP-1 cells were tentatively classified as “metastasis-like/primary” (MLP). Our results provide a comprehensive characterization of three panNET cell lines and demonstrate their relevance as neuroendocrine tumor models.

scholarly journals Gel electrophoretic separation of proteins from cultured neuroendocrine tumor cell lines

2014 ◽  
Vol 11 (2) ◽  
pp. 1407-1415 ◽  
Author(s):  
NATALIA MIĘKUS ◽  
ILONA OLĘDZKA ◽  
ALINA PLENIS ◽  
ZOFIA WOŹNIAK ◽  
ANNA LEWCZUK ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Neuroendocrine Tumor ◽  
Cell Lines ◽  
Electrophoretic Separation ◽  
Tumor Cell Lines ◽  
Separation Of Proteins

scholarly journals Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines

Cancer ◽  
2009 ◽  
Vol 115 (21) ◽  
pp. 4934-4945 ◽  
Author(s):  
Ignat Drozdov ◽  
Mark Kidd ◽  
Bjorn I. Gustafsson ◽  
Bernhard Svejda ◽  
Richard Joseph ◽  
...  
Keyword(s):  
Small Intestine ◽  
Tumor Cell ◽  
Neuroendocrine Tumor ◽  
Signaling Pathways ◽  
Cell Lines ◽  
Tumor Cell Lines

Abstract P024: Antitumoral effect of telotristat ethyl as a single agent in neuroendocrine tumor cell lines and potential synergies

2021 ◽  
Author(s):  
Arantzazu Sierra Ramirez ◽  
Marinela Méndez ◽  
Adrián Plaza ◽  
Andrés Pastor ◽  
Javier Molina Cerrillo ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Neuroendocrine Tumor ◽  
Cell Lines ◽  
Single Agent ◽  
Tumor Cell Lines ◽  
Antitumoral Effect

Abstract 3464: CRISPR-mediated inactivation of ATRX and DAXX in pancreatic neuroendocrine tumor cell lines

2017 ◽  
Author(s):  
Anthony J. Rizzo ◽  
Jacqueline A. Brosnan-Cashman ◽  
Mindy K. Graham ◽  
Alan K. Meeker ◽  
Christopher M. Heaphy
Keyword(s):  
Tumor Cell ◽  
Neuroendocrine Tumor ◽  
Cell Lines ◽  
Pancreatic Neuroendocrine Tumor ◽  
Tumor Cell Lines

scholarly journals Next generation exome sequencing of pancreatic neuroendocrine tumor cell lines BON-1 and QGP-1 reveals different lineages

2015 ◽  
Vol 208 (10) ◽  
pp. 523 ◽  
Author(s):  
Timon Vandamme ◽  
Matthias Beyens ◽  
Marc Peeters ◽  
Guy Van Camp ◽  
Ken Op de Beeck
Keyword(s):  
Tumor Cell ◽  
Neuroendocrine Tumor ◽  
Exome Sequencing ◽  
Cell Lines ◽  
Pancreatic Neuroendocrine Tumor ◽  
Tumor Cell Lines ◽  
Next Generation

Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines

2009 ◽  
Vol 65 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Dhana E. Larsson ◽  
Sadia Hassan ◽  
Rolf Larsson ◽  
Kjell Öberg ◽  
Dan Granberg
Keyword(s):  
Tumor Cell ◽  
Neuroendocrine Tumor ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Cancer Drugs ◽  
Anti Cancer
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