Effects of an outreach and internal navigation program on breast cancer diagnosis in an urban cancer center with a large African-American population

Cancer ◽  
2008 ◽  
Vol 113 (3) ◽  
pp. 602-607 ◽  
Author(s):  
Sheryl G. A. Gabram ◽  
Mary Jo B. Lund ◽  
Jessica Gardner ◽  
Nadjo Hatchett ◽  
Harvey L. Bumpers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Cancer Diagnosis ◽  
Breast Cancer Diagnosis ◽  
Cancer Center ◽  
American Population ◽  
African American Population ◽  
Navigation Program

Recruitment for Breast Cancer Predisposition Studies in an Underserved African American Population

2005 ◽  
Vol 11 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Annette Patterson ◽  
Helen Davis ◽  
David Euhus ◽  
Susan Neuhausen ◽  
Louise Strong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Cancer Predisposition ◽  
American Population ◽  
African American Population ◽  
Breast Cancer Predisposition

Characterization of bone only metastasis (BOM) patients (pts) with respect to tumor subtypes (TS).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 1072-1072
Author(s):  
Amanda Marie Parkes ◽  
Katherine Clifton ◽  
Aydah Al Awadhi ◽  
Oluchi Oke ◽  
Carla L. Warneke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Metastatic Breast ◽  
Breast Cancer Diagnosis ◽  
Cancer Center ◽  
Tumor Subtypes ◽  
Lytic Lesions ◽  
Initial Biopsy ◽  
Md Anderson

1072 Background: Metastatic breast cancer (MBC) pts with BOM are a unique population with limited characterization. Our goal was to characterize the TS of BOM pts, evaluating differences in sites and types of bone metastases (BM), treatment, and survival. Methods: We identified pts followed at MD Anderson Cancer Center from 01/01/1997 to 12/31/2015 for at least 6 months with a BOM diagnosis as first site of metastasis (met). TS was assessed by initial biopsy immunohistochemistry (IHC) (Table 1) with hormone receptor (HR) + defined as ER or PR >10%. Results: We identified 1445 pts with BOM, 1049 with initial biopsy IHC available to group into TS (Table 1). Among BOM pts, the majority had multiple BM at diagnosis (1141/79%), most in both the axial (Ax) and appendicular (App) skeleton (53%). Of the 808 pts with BM categorized on imaging at diagnosis, the majority were lytic (389/48%), with 21% sclerotic, 18% mixed, and 12% blastic. Time from breast cancer diagnosis to first met differed significantly by TS, χ2(3) = 94.33, P< .0001, with median time to met longer for pts with blastic (3.08 years; 95% CI 2.03, 4.24) versus lytic lesions (1.75 years; 95% CI 1.27, 2.17). Conclusions: BOM patients are a unique MBC subpopulation, more commonly found in luminal TS patients. Our study demonstrates prognostic differences in BOM pts specific to TS and emphasizes the need for further study of BOM patients. [Table: see text]

Genetic predisposition to breast cancer among African American women.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 104-104
Author(s):  
Julie R Palmer ◽  
Chunling Hu ◽  
Steven Hart ◽  
Rohan David Gnanaolivu ◽  
Chi Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Cancer Predisposition ◽  
American Population ◽  
African American Population ◽  
Breast Cancer Predisposition ◽  
Predisposition Genes ◽  
History Of ◽  
Brca1 Brca2

104 Background: The identification of pathogenic mutations in breast cancer susceptibility genes through clinical genetic testing leads to focused screening and prevention strategies for women at increased risk of cancer. However, the frequency of mutations and the risks of cancer associated with breast cancer predisposition genes has not been established for the African American population. Methods: Germline DNA samples from African American women (5,054 breast cancer cases and 4,993 age-matched unaffected controls) from 10 U.S. studies were tested for mutations in 20 established breast cancer predisposition genes using a QIAseq multiplex amplicon panel as part of the “CAnceR RIsk Estimates Related to Susceptibility” (CARRIERS) study. The frequency of mutations in each gene and associations between mutations and breast cancer risk, adjusted for study design, age, and first-degree family history of breast cancer, were evaluated. Results: The mean age at diagnosis of breast cancer cases was 54.4 years and the mean age of controls was 55.2 years. 18.2% of cases and 10.8% of controls reported a first-degree family history of breast cancer. Pathogenic mutations in any of the 20 breast cancer predisposition genes were identified in 7.6% of breast cancer cases and 2.4% of controls. In multivariable analyses, mutations in BRCA1, BRCA2, and PALB2 were associated with high risks of breast cancer (odds ratio (OR) > 5.0). Mutations in CHEK2 were associated with moderate risks of breast cancer (OR > 2.0), whereas mutations in ATM had lower clinical relevance (OR = 1.8). Mutations in BRCA1, BRCA2, PALB2, and RAD51D, but not CHEK2 or ATM, were associated with increased risks of estrogen receptor negative breast cancer. Conclusions: Cancer predisposition genes confer similar risks of breast cancer in the African American population as in non-Hispanic Whites. These studies provide important insights into the risks of breast cancer associated with predisposition gene mutations in the African American population.

scholarly journals Genetic Susceptibility Loci for Subtypes of Breast Cancer in an African American Population

2012 ◽  
Vol 22 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Julie R. Palmer ◽  
Edward A. Ruiz-Narvaez ◽  
Charles N. Rotimi ◽  
L. Adrienne Cupples ◽  
Yvette C. Cozier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Genetic Susceptibility ◽  
American Population ◽  
Susceptibility Loci ◽  
African American Population
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