The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor

Cancer ◽  
2008 ◽  
Vol 112 (9) ◽  
pp. 2060-2070 ◽  
Author(s):  
Andrew M. Davidoff ◽  
Dana W. Giel ◽  
Deborah P. Jones ◽  
Jesse J. Jenkins ◽  
Matthew J. Krasin ◽  
...  
2015 ◽  
Vol 31 (3) ◽  
pp. 229-236 ◽  
Author(s):  
Kathleen Kieran ◽  
Andrew M. Davidoff

2013 ◽  
Vol 48 (7) ◽  
pp. 1481-1485 ◽  
Author(s):  
Kathleen Kieran ◽  
Mark A. Williams ◽  
Jeffrey S. Dome ◽  
Lisa M. McGregor ◽  
Matthew J. Krasin ◽  
...  

2017 ◽  
Vol 65 (4) ◽  
pp. e26894 ◽  
Author(s):  
Óscar Girón-Vallejo ◽  
Darío García-Calderón ◽  
Ramón Ruiz-Pruneda ◽  
Rosa Cabello-Laureano ◽  
Ernesto Doménech-Abellán ◽  
...  

Children ◽  
2018 ◽  
Vol 5 (10) ◽  
pp. 134 ◽  
Author(s):  
Andrew Murphy ◽  
Andrew Davidoff

Historically, the management of bilateral Wilms tumor (BWT) was non-standardized and suffered from instances of prolonged chemotherapy and inconsistent surgical management which resulted in suboptimal renal and oncologic outcomes. Because of the risk of end-stage renal disease associated with the management of BWT, neoadjuvant chemotherapy and nephron-sparing surgery have been adopted as the guiding management principles. This management strategy balances acceptable oncologic outcomes against the risk of end-stage renal disease. A recent multi-institutional Children’s Oncology Group study (AREN0534) has confirmed the benefits of standardized 3-drug neoadjuvant chemotherapy and the utilization of nephron-sparing surgery in BWT patients; however, less than 50% of patients underwent bilateral nephron-sparing surgery. The coordination of neoadjuvant chemotherapy and the timing and implementation of bilateral nephron-sparing surgery are features of BWT management that require collaboration between oncologists and surgeons. This review discusses the surgical management strategy in the context of BWT disease biology, with an emphasis on timepoints during therapy at which surgical decision making can greatly impact this disease and minimize long-term toxicities.


2014 ◽  
Vol 49 (1) ◽  
pp. 149-153 ◽  
Author(s):  
Kathleen Kieran ◽  
Mark A. Williams ◽  
Lisa M. McGregor ◽  
Jeffrey S. Dome ◽  
Matthew J. Krasin ◽  
...  

2015 ◽  
Vol 193 (1) ◽  
pp. 262-267 ◽  
Author(s):  
Jochen Hubertus ◽  
Brigitte Günther ◽  
Kristina Becker ◽  
Norbert Graf ◽  
Rhoikos Furtwängler ◽  
...  

2007 ◽  
Vol 178 (4S) ◽  
pp. 1786-1790 ◽  
Author(s):  
Dana W. Giel ◽  
Mark A. Williams ◽  
Deborah P. Jones ◽  
Andrew M. Davidoff ◽  
Jeffrey S. Dome

2018 ◽  
Vol 18 ◽  
pp. 16-18
Author(s):  
Laura DiChiacchio ◽  
Nicole M. Shockcor ◽  
Regina Macatangay ◽  
Eric Strauch

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