Reproductive history, infertility treatment, and the risk of acute leukemia in children with down syndrome

Cancer ◽  
2007 ◽  
Vol 110 (9) ◽  
pp. 2067-2074 ◽  
Author(s):  
Susan E. Puumala ◽  
Julie A. Ross ◽  
Andrew F. Olshan ◽  
Leslie L. Robison ◽  
Franklin O. Smith ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Leukemia ◽  
Infertility Treatment ◽  
Reproductive History ◽  
Children With Down Syndrome ◽  
Leukemia In Children

Neuropsychological late effects of treatment for acute leukemia in children with Down syndrome

2014 ◽  
Vol 62 (5) ◽  
pp. 854-858 ◽  
Author(s):  
Caroline Roncadin ◽  
Johann Hitzler ◽  
Andrea Downie ◽  
Isabelle Montour-Proulx ◽  
Cheryl Alyman ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Leukemia ◽  
Late Effects ◽  
Children With Down Syndrome ◽  
Leukemia In Children

scholarly journals Infections and Acute Leukemia in Children with Down Syndrome

10.5772/18533 ◽  
2011 ◽  
Author(s):  
Juan Manuel ◽  
Maria Luisa ◽  
Janet Flores-Lujano ◽  
Carolina Bekker ◽  
Sandra Pinto-Cardoso ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Leukemia ◽  
Children With Down Syndrome ◽  
Leukemia In Children

scholarly journals Maternal health conditions during pregnancy and acute leukemia in children with Down syndrome: A Children's Oncology Group study

2009 ◽  
Vol 52 (5) ◽  
pp. 602-608 ◽  
Author(s):  
Simona Ognjanovic ◽  
Susan Puumala ◽  
Logan G. Spector ◽  
Franklin O. Smith ◽  
Leslie L. Robison ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Maternal Health ◽  
Acute Leukemia ◽  
Health Conditions ◽  
Oncology Group ◽  
Oncology Group Study ◽  
Children With Down Syndrome ◽  
Leukemia In Children

Maternal and Birth Characteristics and Risk of Leukemia in Children with Down Syndrome.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 861-861
Author(s):  
Michelle A. Roesler ◽  
Cindy K. Blair ◽  
Logan G. Spector ◽  
Leslie L. Robison ◽  
Andrew F. Olshan ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Birth Weight ◽  
Acute Leukemia ◽  
Maternal Age ◽  
Childhood Leukemia ◽  
Advanced Maternal Age ◽  
Children With Down Syndrome ◽  
Increased Risk ◽  
Birth Characteristics ◽  
Leukemia In Children

Abstract High birth weight (> 4000 g) is a risk factor for childhood leukemia, especially for younger children. Advanced maternal age has also been associated with an increased risk, though less consistently than birth weight. Because children with Down syndrome (DS) are at a 20-fold increased risk of developing acute leukemia than the general population, we evaluated maternal and child birth characteristics that may be associated with leukemia in children with DS. A case-control study of DS and acute leukemia was conducted through the Children’s Oncology Group in North America. From 1997 to 2002, 158 children ages birth-18 years with DS and acute leukemia (including 61 acute myeloid leukemia (AML) and 97 acute lymphoblastic leukemia (ALL)) were enrolled. Children with DS alone (n= 173) were identified through the cases’ pediatric clinics and frequency matched to cases on age. Mothers of cases and controls completed a telephone interview that included questions regarding maternal and birth characteristics. Here, we present data related to singleton pregnancies (165 controls and 151 cases (96 ALL/55AML)). Advanced maternal age (≥ 35 vs. <35) was associated with an elevated risk of leukemia (Odds Ratio (OR)=1.79, 95% Confidence Interval (CI))=1.09–2.94), which was apparent for both ALL and AML. There was also a suggestion of an increased risk for children in the highest tertile (>3260 g) of birth weight (OR=1.56, 95% CI=0.87–2.78) compared to children in the reference group (2850–3260 g). Birth length ≥ 21 inches showed an increased risk for AML cases only (OR=3.06; CI=1.25–7.50). In contrast, increasing birth order was associated with a decreased risk, particularly for AML (OR=0.36; 95% CI 0.14–0.97). This is the first study to evaluate maternal and child birth characteristics in relation to leukemia risk in children with DS. Our results add to the growiA. ng body of evidence that suggests that newborn body size may be related to the underlying etiology of childhood leukemia.

GATA1 mutations in acute leukemia in children with Down syndrome

2006 ◽  
Vol 166 (2) ◽  
pp. 112-116 ◽  
Author(s):  
Isis Quezado Magalhães ◽  
Alessandra Splendore ◽  
Mariana Emerenciano ◽  
Alexandre Figueiredo ◽  
Íris Ferrari ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Leukemia ◽  
Children With Down Syndrome ◽  
Leukemia In Children

Magnetic Fields and Acute Leukemia in Children With Down Syndrome

Epidemiology ◽  
2007 ◽  
Vol 18 (1) ◽  
pp. 158-161 ◽  
Author(s):  
Juan Manuel Mejia-Arangure ◽  
Arturo Fajardo-Gutierrez ◽  
Maria Luisa Perez-Saldivar ◽  
Clara Gorodezky ◽  
Armando Martinez-Avalos ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Magnetic Fields ◽  
Acute Leukemia ◽  
Children With Down Syndrome ◽  
Leukemia In Children

scholarly journals Immune-Related Conditions and Acute Leukemia in Children with Down Syndrome: A Children's Oncology Group Report

2014 ◽  
Vol 24 (2) ◽  
pp. 454-458 ◽  
Author(s):  
Amy M. Linabery ◽  
Wenchao Li ◽  
Michelle A. Roesler ◽  
Logan G. Spector ◽  
Alan S. Gamis ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Leukemia ◽  
Oncology Group ◽  
Children With Down Syndrome ◽  
Group Report ◽  
Leukemia In Children

P079 Relation between magnetic fields and acute leukemia in children with Down syndrome

Blood Reviews ◽  
2007 ◽  
Vol 21 ◽  
pp. S111
Author(s):  
J.M. Mejía-Aranguré ◽  
A. Fajardo-Gutiérrez ◽  
M.L. Pérez-Saldivar ◽  
L. Velásquez-Pérez ◽  
R. Bernáldez-Ríos ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Magnetic Fields ◽  
Acute Leukemia ◽  
Children With Down Syndrome ◽  
Leukemia In Children

scholarly journals Acute leukemia in children with Down syndrome

Haematologica ◽  
2010 ◽  
Vol 95 (7) ◽  
pp. 1043-1045 ◽  
Author(s):  
A. C. Xavier ◽  
J. W. Taub
Keyword(s):  
Down Syndrome ◽  
Acute Leukemia ◽  
Children With Down Syndrome ◽  
Leukemia In Children
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