scholarly journals Genetic polymorphisms in DNA base-excision repair genesADPRT,XRCC1, andAPE1 and the risk of squamous cell carcinoma of the head and neck

Cancer ◽  
2007 ◽  
Vol 110 (4) ◽  
pp. 867-875 ◽  
Author(s):  
Chunying Li ◽  
Zhibin Hu ◽  
Jiachun Lu ◽  
Zhensheng Liu ◽  
Li-E Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Genetic Polymorphisms ◽  
Base Excision Repair ◽  
Squamous Cell ◽  
Excision Repair ◽  
Dna Base Excision Repair ◽  
Dna Base ◽  
Base Excision

IMMUNOEXPRESSION OF DNA BASE EXCISION REPAIR PROTEINS IN ORAL TONGUE SQUAMOUS CELL CARCINOMA

2017 ◽  
Vol 124 (2) ◽  
pp. e128
Author(s):  
THALITA SANTANA CONCEIÇÃO ◽  
MELKA COÊLHO SÁ ◽  
EDILMAR DE MOURA SANTOS ◽  
VIVIANE ALVES DE OLIVEIRA ◽  
ÉRICKA JANINE DANTAS DA SILVEIRA ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Base Excision Repair ◽  
Squamous Cell ◽  
Excision Repair ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue ◽  
Dna Base Excision Repair ◽  
Dna Base ◽  
Base Excision

Association between polymorphisms in genes related to DNA base-excision repair with risk and prognosis of oropharyngeal squamous cell carcinoma

2016 ◽  
Vol 142 (9) ◽  
pp. 1917-1926 ◽  
Author(s):  
Ericka Francislaine Dias Costa ◽  
Erika Stocco Santos ◽  
Vitor Teixeira Liutti ◽  
Frederico Leal ◽  
Vivian Castro Antunes Santos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Base Excision Repair ◽  
Squamous Cell ◽  
Excision Repair ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Dna Base Excision Repair ◽  
Dna Base ◽  
Base Excision

DNA base excision repair proteins APE-1 and XRCC-1 are overexpressed in oral tongue squamous cell carcinoma

2017 ◽  
Vol 46 (7) ◽  
pp. 496-503 ◽  
Author(s):  
Thalita Santana ◽  
Melka Coêlho Sá ◽  
Edilmar de Moura Santos ◽  
Hébel Cavalcanti Galvão ◽  
Ricardo D. Coletta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Base Excision Repair ◽  
Squamous Cell ◽  
Excision Repair ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue ◽  
Dna Base Excision Repair ◽  
Dna Base ◽  
Base Excision

scholarly journals Molecular Markers of Anticancer Drug Resistance in Head and Neck Squamous Cell Carcinoma: A Literature Review

Cancers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 376 ◽  
Author(s):  
Sandra López-Verdín ◽  
Jesús Lavalle-Carrasco ◽  
Ramón Carreón-Burciaga ◽  
Nicolás Serafín-Higuera ◽  
Nelly Molina-Frechero ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Excision Repair ◽  
Dna Lesions ◽  
Neck Squamous Cell Carcinoma ◽  
Tumor Resistance ◽  
Base Excision

This manuscript provides an update to the literature on molecules with roles in tumor resistance therapy in head and neck squamous cell carcinoma (HNSCC). Although significant improvements have been made in the treatment for head and neck squamous cell carcinoma, physicians face yet another challenge—that of preserving oral functions, which involves the use of multidisciplinary therapies, such as multiple chemotherapies (CT) and radiotherapy (RT). Designing personalized therapeutic options requires the study of genes involved in drug resistance. This review provides an overview of the molecules that have been linked to resistance to chemotherapy in HNSCC, including the family of ATP-binding cassette transporters (ABCs), nucleotide excision repair/base excision repair (NER/BER) enzymatic complexes (which act on nonspecific DNA lesions generated by gamma and ultraviolet radiation by cross-linking and forming intra/interchain chemical adducts), cisplatin (a chemotherapeutic agent that causes DNA damage and induces apoptosis, which is a paradox because its effectiveness is based on the integrity of the genes involved in apoptotic signaling pathways), and cetuximab, including a discussion of the genes involved in the cell cycle and the proliferation of possible markers that confer resistance to cetuximab.

Sign in / Sign up

Export Citation Format

Share Document