scholarly journals Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma

Cancer ◽  
2007 ◽  
Vol 109 (11) ◽  
pp. 2315-2322 ◽  
Author(s):  
Rashmi Chugh ◽  
Thomas Wagner ◽  
Kent A. Griffith ◽  
Jeremy M.G. Taylor ◽  
Dafydd G. Thomas ◽  
...  
Keyword(s):  
Breath Test ◽  
Cyp3a4 Activity ◽  
Erythromycin Breath Test

scholarly journals Troglitazone Induces CYP3A4 Activity Leading to Falsely Abnormal Dexamethasone Suppression Test

2003 ◽  
Vol 88 (7) ◽  
pp. 3113-3116 ◽  
Author(s):  
Eleni V. Dimaraki ◽  
Craig A. Jaffe
Keyword(s):  
Breath Test ◽  
Plasma Corticosterone ◽  
Dexamethasone Suppression Test ◽  
Screening Tests ◽  
Cyp3a4 Activity ◽  
Abnormal Response ◽  
Before And After ◽  
Erythromycin Breath Test ◽  
Suppression Test ◽  
Dexamethasone Suppression

After evaluating a patient who appeared to have a falsely abnormal response to the dexamethasone suppression test while taking troglitazone, we examined the effects of troglitazone on the activity of hepatic CYP3A4 and the screening tests for Cushing’s syndrome. We studied five healthy women and three healthy men, aged 25 ± 2 yr, before and after treatment with troglitazone (600 mg daily) for 28 d. Baseline 0800 h cortisol and corticosterone were similar before and after troglitazone treatment. Before troglitazone treatment, all subjects suppressed 0800 h cortisol below 1.8 μg/dl (mean, 0.66 ± 0.08 μg/dl) during the 1-mg overnight dexamethasone suppression test (DST), whereas during troglitazone treatment none of the subjects suppressed 0800 h cortisol below 1.8 μg/dl (mean, 9.0 ± 1.8 μg/dl). Serum dexamethasone levels decreased by 66 ± 4%, and the erythromycin breath test measurements increased by 27 ± 8%, indicating increased CYP3A4 activity during troglitazone treatment. The hydrocortisone suppression test (HST) was performed by administering 50 mg hydrocortisone at 2300 h. Using the criterion of suppression of 0800 h plasma corticosterone by more than 50%, the specificity of the HST was 100% both before and after troglitazone treatment. In conclusion, troglitazone induced the activity of CYP3A4 leading to falsely abnormal DST. HST is a useful alternative to the DST in patients taking medications that increase the activity of CYP3A4.

scholarly journals Comparison of urinary 6-β-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

1992 ◽  
Vol 52 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Paul B Watkins ◽  
D Kim Turgeon ◽  
Paul Saenger ◽  
Kenneth S Lown ◽  
Joseph C Kolars ◽  
...  
Keyword(s):  
Breath Test ◽  
Cyp3a Activity ◽  
Erythromycin Breath Test

Erythromycin breath test

2001 ◽  
Vol 70 (4) ◽  
pp. 0395-0397 ◽  
Author(s):  
Laurent P. Rivory ◽  
Paul B. Watkins
Keyword(s):  
Breath Test ◽  
Erythromycin Breath Test

PREDICTION OF INTERPATIENT AND INTRAPATIENT VARIATION IN OG 37–325 DOSING REQUIREMENTS BY THE ERYTHROMYCIN BREATH TEST

1994 ◽  
Vol 57 (12) ◽  
pp. 1736-1741 ◽  
Author(s):  
D. Kim Turgeon ◽  
Alan B. Leichtman ◽  
Debbie S. Blake ◽  
Robert L. Schmouder ◽  
Kenneth S. Lown ◽  
...  
Keyword(s):  
Breath Test ◽  
Erythromycin Breath Test

scholarly journals Gefitinib-phenytoin interaction is not correlated with the14C-erythromycin breath test in healthy male volunteers

2009 ◽  
Vol 68 (2) ◽  
pp. 226-237 ◽  
Author(s):  
Stephanie Chhun ◽  
Celine Verstuyft ◽  
Nathalie Rizzo-Padoin ◽  
Guy Simoneau ◽  
Laurent Becquemont ◽  
...  
Keyword(s):  
Breath Test ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Erythromycin Breath Test
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