Presalvage prostate-specific antigen (PSA) and PSA doubling time as predictors of biochemical failure of salvage cryotherapy in patients with locally recurrent prostate cancer after radiotherapy

Cancer ◽  
2006 ◽  
Vol 107 (2) ◽  
pp. 275-280 ◽  
Author(s):  
Philippe E. Spiess ◽  
Andrew K. Lee ◽  
Dan Leibovici ◽  
Xuemei Wang ◽  
Kim-Anh Do ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Doubling Time ◽  
Specific Antigen ◽  
Biochemical Failure ◽  
Recurrent Prostate Cancer ◽  
Psa Doubling Time ◽  
Salvage Cryotherapy ◽  
Locally Recurrent

Prostate-specific antigen (PSA) kinetics in untreated, localized prostate cancer: PSA velocity vs PSA doubling time

2009 ◽  
Vol 103 (7) ◽  
pp. 872-876 ◽  
Author(s):  
Michael K. Ng ◽  
Nicholas Van As ◽  
Karen Thomas ◽  
Ruth Woode-Amissah ◽  
Alan Horwich ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Doubling Time ◽  
Specific Antigen ◽  
Localized Prostate Cancer ◽  
Psa Kinetics ◽  
Psa Doubling Time ◽  
Psa Velocity

scholarly journals Natural History of Untreated Prostate Specific Antigen Radiorecurrent Prostate Cancer in Men with Favorable Prognostic Indicators

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Neil E. Martin ◽  
Ming-Hui Chen ◽  
Clair J. Beard ◽  
Paul L. Nguyen ◽  
Marian J. Loffredo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Doubling Time ◽  
Cox Regression ◽  
Specific Antigen ◽  
Risk Of Death ◽  
Psa Doubling Time ◽  
Increased Risk ◽  
Psa Failure ◽  
Post Radiation

Background and Purpose. Life expectancy data could identify men with favorable post-radiation prostate-specific antigen (PSA) failure kinetics unlikely to require androgen deprivation therapy (ADT).Materials and Methods. Of 206 men with unfavorable-risk prostate cancer in a randomized trial of radiation versus radiation and ADT, 53 experienced a PSA failure and were followed without salvage ADT. Comorbidity, age and established prognostic factors were assessed for relationship to death using Cox regression analyses.Results. The median age at failure, interval to PSA failure, and PSA doubling time were 76.6 years (interquartile range [IQR]: 71.8–79.3), 49.1 months (IQR: 37.7–87.4), and 25 months (IQR: 13.1–42.8), respectively. After a median follow up of 4.0 years following PSA failure, 45% of men had died, none from prostate cancer and no one had developed metastases. Both increasing age at PSA failure (HR: 1.14; 95% CI: 1.03–1.25;P=0.008) and the presence of moderate to severe comorbidity (HR: 12.5; 95% CI: 3.81–41.0;P<0.001) were significantly associated with an increased risk of death.Conclusions. Men over the age of 76 with significant comorbidity and a PSA doubling time >2 years following post-radiation PSA failure appear to be good candidates for observation without ADT intervention.

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