scholarly journals Herrstedt J, Muss HB, Warr DG, et al. Efficacy and tolerability of aprepitant for the prevention of chemotherapy-induced nausea and emesis over multiple cycles of moderately emetogenic chemotherapy.Cancer. 2005;104:1548–55.

Cancer ◽  
2006 ◽  
Vol 106 (7) ◽  
pp. 1641-1641
Keyword(s):  
Nausea And Emesis ◽  
Multiple Cycles

scholarly journals Efficacy and tolerability of aprepitant for the prevention of chemotherapy-induced nausea and emesis over multiple cycles of moderately emetogenic chemotherapy

Cancer ◽  
2005 ◽  
Vol 104 (7) ◽  
pp. 1548-1555 ◽  
Author(s):  
Jørn Herrstedt ◽  
Hyman B. Muss ◽  
David G. Warr ◽  
Paul J. Hesketh ◽  
Peter D. Eisenberg ◽  
...  
Keyword(s):  
Emetogenic Chemotherapy ◽  
Moderately Emetogenic Chemotherapy ◽  
Nausea And Emesis ◽  
Multiple Cycles

scholarly journals Obsidian pyroclasts in the Yellowstone-Snake River Plain ignimbrites are dominantly juvenile in origin

2021 ◽  
Vol 83 (4) ◽  
Author(s):  
L. R. Monnereau ◽  
B. S. Ellis ◽  
D. Szymanowski ◽  
O. Bachmann ◽  
M. Guillong
Keyword(s):  
Glass Composition ◽  
Snake River Plain ◽  
Explosive Eruptions ◽  
Snake River ◽  
Pyroclastic Deposits ◽  
Volcanic Conduit ◽  
Trace Elemental ◽  
Multiple Cycles ◽  
River Plain ◽  
Glass Compositions

AbstractDense, glassy pyroclasts found in products of explosive eruptions are commonly employed to investigate volcanic conduit processes through measurement of their volatile inventories. This approach rests upon the tacit assumption that the obsidian clasts are juvenile, that is, genetically related to the erupting magma. Pyroclastic deposits within the Yellowstone-Snake River Plain province almost without exception contain dense, glassy clasts, previously interpreted as hyaloclastite, while other lithologies, including crystallised rhyolite, are extremely rare. We investigate the origin of these dense, glassy clasts from a coupled geochemical and textural perspective combining literature data and case studies from Cougar Point Tuff XIII, Wolverine Creek Tuff, and Mesa Falls Tuff spanning 10 My of silicic volcanism. These results indicate that the trace elemental compositions of the dense glasses mostly overlap with the vesiculated component of each deposit, while being distinct from nearby units, thus indicating that dense glasses are juvenile. Textural complexity of the dense clasts varies across our examples. Cougar Point Tuff XIII contains a remarkable diversity of clast appearances with the same glass composition including obsidian-within-obsidian clasts. Mesa Falls Tuff contains clasts with the same glass compositions but with stark variations in phenocryst content (0 to 45%). Cumulatively, our results support a model where most dense, glassy clasts reflect conduit material that passed through multiple cycles of fracturing and sintering with concurrent mixing of glass and various crystal components. This is in contrast to previous interpretations of these clasts as entrained hyaloclastite and relaxes the requirement for water-magma interaction within the eruptive centres of the Yellowstone-Snake River Plain province.

Periodicity of insulin secretion comprises multiple cycles with different duration in perfused rat islets

1992 ◽  
Vol 17 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Koji Yarimizu ◽  
Nagamasa Kawano ◽  
Junko Ono ◽  
Ryosaburo Takaki
Keyword(s):  
Insulin Secretion ◽  
Rat Islets ◽  
Multiple Cycles

DEVS OS (Discrete Even Visualization and Simulation Operating System)

2018 ◽  
Author(s):  
Adnan Hajar
Keyword(s):  
Operating System ◽  
Operating Systems ◽  
Scheduling Algorithm ◽  
The Novel ◽  
Priority Scheduling ◽  
First Come First Serve ◽  
Multiple Cycles ◽  
Visualization And Simulation ◽  
Traditional Approaches

The use of traditional approaches to teach Operating Systems usually lacks the visual aspect. The following research investigates the novel use of DEVS (Discrete Even Visualization and Simulation) in simulating the operation of an operating system. Cd boost++ was the framework of choice for this project. The simulation successfully mimicked the work of an operating system by simulating multiple cycles of program requests. This simulation is capable of further enhance the explanation of how an operating system works. The cases studied in this work include: 1- two processes running concurrently doing multiple IO’s, 2-four processes running concurrently based on a first come first serve scheduling algorithm, and 3- 20 processes running concurrently using highest priority scheduling algorithm. Output observation of the last case show promising results of successful use of DEVS and cd boost++ as a framework to build an operating system.

Advancing Translational Research by Enabling Collaborative Teamwork: The TRACT Approach

2012 ◽  
Vol 2 (3) ◽  
Author(s):  
Nedal H. Arar ◽  
Divya Nandamudi
Keyword(s):  
Content Analysis ◽  
Translational Research ◽  
Research Work ◽  
Structured Interviews ◽  
Team Collaboration ◽  
Team Members ◽  
Effective Strategies ◽  
Multiple Cycles ◽  
And Function ◽  
Collaborative Activities

Background: The work of multidisciplinary research teams (MDRTs) is vital for translational research. The objectives of this study were 1) to understand the structure and function of MDRTs, and 2) to develop effective strategies to enhance collaboration among team members. Methods and Findings: Semi-structured interviews were conducted with 23 participants involved in multidisiplinary research work at two San Antonio, Texas, institutions. Interview materials were tape-recorded, transcribed, and content analyzed using qualitative methods.Themes that emerged from the content analysis were used to develop and refine strategies to enhance the work of MDRTs. The findings showed that MDRTs operate through multiple cycles of: 1) team formation, 2) team collaboration, 3) sustainable collaborative activities, and 4) team maturity. Content analysis identified four interrelated basic elements within the MDRT tract that facilitate team cycles: 1) shared interest/vision among agreeable team leader and members, 2) viable means of communication, 3) available resources, and 4) perceived gain/benefit of teamwork.Conclusions: Our findings highlighted several opportunities and challenges in the formation, dynamics, and growth of MDRTs. Effective strategies to enhance teamwork should levearge these opportunities and address challenges, taking into consideration the interdependent aspects of the basic elements within the MDRTs tract.

Further Characterization of the Potent and Prolonged Inhibition of Herpes Simplex Virus Replication in Human Cell Lines by Penciclovir

1996 ◽  
Vol 7 (3) ◽  
pp. 128-137 ◽  
Author(s):  
T.H. Bacon ◽  
B.A. Howard
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cell Lines ◽  
Virus Replication ◽  
Human Cell ◽  
Human Cell Lines ◽  
Potent Inhibition ◽  
Multiple Cycles ◽  
Simplex Virus ◽  
Hsv 1

The replication of herpes simplex virus type 1 (HSV-1) or HSV-2 in MRC-5 cells infected at 0.01 pfu cell−1 treated continuously for 72 h, was inhibited more efficiently by penciclovir than aciclovir ( p = 0.0001). However, multiple cycles of replication were required in order to distinguish the compounds. Virus from cultures treated for 72 h with either compound, at 3 or 10 μg ml−1 was resistant to penciclovir and aciclovir (50% effective concentrations > 10 μg ml−1), but infectivity titres of supernatants from these aciclovirtreated cultures were higher than for penciclovir. Increased production of resistant virus in aciclovirtreated cultures may be the consequence of the less potent inhibition of virus replication by aciclovir. Penciclovir caused prolonged inhibition of HSV-1 and HSV-2 replication in three human cell lines infected at 1 pfu cell−1 following treatment for 18 h, whereas virus replication resumed rapidly after withdrawal of aciclovir. Neither compound showed prolonged activity after 18 h treatment, when the multiplicity of infection was reduced to 0.01 pfu cell−1. This surprising observation prompted experiments testing the effect of repeated pulse treatment in cultures infected at low multiplicity. Penciclovir inhibited HSV-1 replication significantly more effectively than aciclovir in MRC-5 cells infected at 10−4 pfu cell−1 treated daily for 6 h ( p < 0.001, n = 5) but only a trend was observed for HSV-2 ( p = 0.06, n = 6).

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