scholarly journals Cervical cytology of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H)

Cancer ◽  
2006 ◽  
Vol 108 (5) ◽  
pp. 298-305 ◽  
Author(s):  
Mark E. Sherman ◽  
Philip E. Castle ◽  
Diane Solomon
Keyword(s):  
Cervical Cytology ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Squamous Cells ◽  
Intraepithelial Lesion

Is Atypical Squamous Cells That Cannot Exclude High-grade Squamous Intraepithelial Lesion Clinically Significant?

2007 ◽  
Vol 11 (2) ◽  
pp. 86-89 ◽  
Author(s):  
Michael T. McHale ◽  
Jessica Souther ◽  
John C. Elkas ◽  
Bradley J. Monk ◽  
Terry A. Harrison
Keyword(s):  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Squamous Cells ◽  
Intraepithelial Lesion ◽  
Clinically Significant

scholarly journals p16 immunostaining can avoid overdiagnosis in postmenopausal cervical cytology

2021 ◽  
Vol 9 (1) ◽  
pp. 1-8
Author(s):  
Yutaka Tsutsumi ◽  
◽  
Kazuya Shiogama ◽  
Ken Sakurai ◽  
Toru Arase ◽  
...  
Keyword(s):  
Cervical Cytology ◽  
Sampling Errors ◽  
Squamous Intraepithelial Lesion ◽  
Squamous Cells ◽  
Glass Slides ◽  
Intraepithelial Lesion ◽  
P16 Ink4a ◽  
Age Range ◽  
Chronic Cervicitis ◽  
P16 Expression

Senile (atrophic) colpitis is microscopically characterized by the predominance of parabasal squamous cells and the paucity of superficial cells. The activated parabasal cells or dyskeratotic superficial cells may be confused with squamous intraepithelial lesion (SIL) in the routine cytology practice. A total of 29 cervical cytology specimens diagnosed as atypical squamous cells (ASC) or SIL were retrospectively sampled from 24 postmenopausal women (age range: 56–84 years, mean: 65.5, median: 65). Cytological diagnoses in the routine services included ASC-US 20, ASC-H 2, LSIL 4 and HSIL 3. All the specimens showed an atrophic background (senile colpitis). There were two microscopic patterns of senile colpitis with atypia: 1) parabasal cells were clustered (n = 23) and 2) dyskeratotic superficial cells were seen in a highly inflamed background (n = 6). Immunostaining for p16-INK4a (p16 in short) was performed, after the cells were transferred to trimethoxy[3-(phenylamino)propyl]silane-coated glass slides. Only three of the 29 cytology specimens (two of the 24 cases) judged as HSIL cytologically revealed p16 positivity in clustered atypical parabasal cells. Biopsy was performed in 11 cases, and chronic cervicitis without p16 expression was seen in nine. Two lesions showed p16-positive dysplasia (one mild dysplasia and another moderate dysplasia). In one lesion in an 84 year-old female, both cytology and histology specimens showed p16 positivity (HSIL). Discrepancy of p16 expression between the cytology and histology specimens was encountered in two lesions, representing sampling errors. It is of note that the overcytodiagnosis is avoidable with the aid of p16 immunostaining. Keywords: Atypical squamous cells (ASC), cell transfer technique, p16-INK4a, senile colpitis, squamous intraepithelial lesion (SIL).

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