scholarly journals Cytologic findings and protein expression profiles associated with ductal carcinoma of the breast in ductal lavage specimens using surface-enhanced laser desorption and ionization-time of flight mass spectrometry

Cancer ◽  
2005 ◽  
Vol 105 (3) ◽  
pp. 178-183 ◽  
Author(s):  
Savvas Mendrinos ◽  
John David L. Nolen ◽  
Toncred Styblo ◽  
Grant Carlson ◽  
Jan Pohl ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ductal Carcinoma ◽  
Expression Profiles ◽  
Laser Desorption ◽  
Ductal Lavage ◽  
Carcinoma Of The Breast ◽  
Ionization Time ◽  
Flight Mass Spectrometry ◽  
Surface Enhanced ◽  
Protein Expression Profiles

Investigation of Tissue Inhibitor of Metalloproteinases 1 in Plasma from Colorectal Cancer Patients and Blood Donors by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

2007 ◽  
Vol 22 (2) ◽  
pp. 89-94 ◽  
Author(s):  
M.B. Caspersen ◽  
N.M. Sørensen ◽  
A.S. Schrohl ◽  
P. Iversen ◽  
H.J. Nielsen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mass Spectrometry ◽  
Laser Desorption ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Laser Desorption Ionization ◽  
Ionization Time ◽  
Desorption Ionization ◽  
Flight Mass Spectrometry ◽  
Surface Enhanced ◽  
Tof Ms

Early detection of colorectal cancer (CRC) improves patient survival. Plasma tissue inhibitor of metalloproteinases 1 (TIMP-1) measurements by enzyme-linked immunosorbent assay (ELISA) have been suggested as a new method for the early detection of CRC. To further investigate the nature of TIMP-1 in plasma, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI TOF MS) was used. TIMP-1 measurements of plasma from 16 healthy donors and 14 CRC patients were performed using TIMP-1 monoclonal antibody in SELDI TOF MS and ELISA. SELDI TOF MS applying an antibody to TIMP-1 revealed that human plasma TIMP-1 has a mass of 25.1 kDa and exhibits several isoforms. Both methods showed increased plasma TIMP-1 values for cancer patients as compared to healthy individuals. The p values for the separation of the groups were 0.0019 for ELISA and <0.0001 for SELDI TOF MS. CRC did not fundamentally affect the appearance of TIMP-1 as evaluated by SELDI TOF MS.

scholarly journals Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma

Cancer ◽  
2006 ◽  
Vol 107 (1) ◽  
pp. 99-107 ◽  
Author(s):  
David Wing Yuen Ho ◽  
Zhen Fan Yang ◽  
Birgitta Yee-Hang Wong ◽  
Dora Lai-Wan Kwong ◽  
Jonathan Shun-Tong Sham ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nasopharyngeal Carcinoma ◽  
Serum Protein ◽  
Laser Desorption ◽  
Protein Profiling ◽  
Laser Desorption Ionization ◽  
Ionization Time ◽  
Desorption Ionization ◽  
Flight Mass Spectrometry ◽  
Surface Enhanced
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