scholarly journals Alteration of the E-cadherin/?-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids

Cancer ◽  
2005 ◽  
Vol 103 (6) ◽  
pp. 1154-1164 ◽  
Author(s):  
Giuseppe Pelosi ◽  
Aldo Scarpa ◽  
Giacomo Puppa ◽  
Giulia Veronesi ◽  
Lorenzo Spaggiari ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Neuroendocrine Tumors ◽  
Independent Predictor ◽  
Node Metastasis ◽  
Adhesion System ◽  
E Cadherin

scholarly journals High vimentin expression with E-cadherin expression loss predicts a poor prognosis after resection of grade 1 and 2 pancreatic neuroendocrine tumors

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bo Zhou ◽  
Jie Xiang ◽  
Ming Jin ◽  
Xiang Zheng ◽  
Guogang Li ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Neuroendocrine Tumors ◽  
Distant Metastasis ◽  
Poor Prognosis ◽  
Prognostic Significance ◽  
Pancreatic Neuroendocrine Tumors ◽  
Vimentin Expression ◽  
Node Metastasis ◽  
E Cadherin

Abstract Background Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms with malignant behaviors that can develop from inert slow growth or low malignancy to aggressive metastasis during follow-up. Recently, vimentin and E-cadherin were shown to be prognostic markers in some malignant tumors but were not evaluated in pNETs. The aim of this study was to evaluate the expression and prognostic significance of vimentin and E-cadherin in grade 1 and 2 pNETs. Methods A retrospective review of 227 patients with grade 1 and 2 pNETs undergoing surgical resection was conducted. Tumor specimens were immunohistochemically stained for vimentin and E-cadherin. Correlations between vimentin and E-cadherin expression and other clinicopathological features were then analyzed. Furthermore, overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier and univariate and multivariate Cox regression methods. Results Among 227 patients, 55 (24.2%) harbored tumors with high vimentin expression, while 117 (51.5%) harbored tumors with loss of E-cadherin expression. Patients with high vimentin expression and loss of E-cadherin expression had significantly elevated risks of lymph node metastasis, distant metastasis, perineural invasion and an advanced American Joint Committee on Cancer (AJCC) stage compared with those with low vimentin expression and preserved E-cadherin expression, high vimentin expression and preserved E-cadherin expression, or low vimentin expression and loss of E-cadherin expression. Furthermore, multivariate analysis showed that high vimentin expression with loss of E-cadherin expression was an independent predictor of OS and DFS in patients with grade 1 and 2 pNETs who underwent resection (both P < 0.001). Conclusions The current study demonstrated that high vimentin expression with loss of E-cadherin expression was correlated with lymph node metastasis, distant metastasis, disease progression and a poor prognosis in patients with grade 1 and 2 pNETs who underwent resection.

scholarly journals Difficulty of predicting lymph node metastasis on CT in patients with rectal neuroendocrine tumors

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0211675 ◽  
Author(s):  
Hajime Ushigome ◽  
Yosuke Fukunaga ◽  
Toshiya Nagasaki ◽  
Takashi Akiyoshi ◽  
Tsuyoshi Konishi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Neuroendocrine Tumors ◽  
Node Metastasis

Clinical significance of E-cadherin, β-catenin, vimentin and S100A4 expression in completely resected squamous cell lung carcinoma

2013 ◽  
Vol 66 (11) ◽  
pp. 937-945 ◽  
Author(s):  
Hua Zhang ◽  
Jun Liu ◽  
Dongsheng Yue ◽  
Liuwei Gao ◽  
Daowei Wang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Prognostic Value ◽  
Squamous Cell Lung Carcinoma ◽  
Histological Differentiation ◽  
Vimentin Expression ◽  
Cell Lung Carcinoma ◽  
Node Metastasis ◽  
S100a4 Expression ◽  
E Cadherin

ObjectiveThe aim of this study was to evaluate the prognostic value of E-cadherin, β-catenin, vimentin and S100A4 expression in a cohort of squamous cell lung carcinoma (SqCC) patients.MethodsTumours from 204 patients with surgically resected SqCC were used for the immunohistochemical analyses of E-cadherin, β-catenin, vimentin and S100A4 expression. Correlations between the expression of these markers and clinicopathological parameters were analysed using the χ2 test. The prognostic value of these markers was evaluated using univariate Kaplan–Meier survival analyses and multivariate Cox proportional hazards model analyses.ResultsSignificant associations between E-cadherin expression and T stage (p=0.040), histological differentiation (p=0.005), lymph node metastasis (p<0.001), and recurrence (p<0.001) were identified. Decreased β-catenin expression was significantly correlated with T stage (p=0.003) and lymph node metastasis (p=0.010). Vimentin expression was associated with histological differentiation (p=0.017) and lymph node metastasis (p=0.001). Moreover, significant correlations were observed between S100A4 expression and lymph node metastasis (p=0.020) and recurrence (p<0.001). In the univariate analyses, high E-cadherin expression was a positive indicator for overall survival (OS) (p<0.001) and disease-free survival (DFS) (p<0.001), whereas high S100A4 or vimentin expression were negative indicators for OS (p<0.001 and p=0.010, respectively) and DFS (p<0.001 and p=0.006, respectively). In the multivariate analyses, E-cadherin and S100A4 expression were independent prognostic factors for OS (HR 0.697, 95% CI 0.524 to 0.926, p=0.013, and HR 1.508, 95% CI 1.122 to 2.027, p=0.007, respectively) and DFS (HR 0.634, 95% CI 0.471 to 0.852, p=0.003, and HR 1.490, 95% CI 1.101 to 2.015, p=0.010, respectively).ConclusionsEffective analysis of E-cadherin and S100A4 expression may allow for the identification of patients who are at a high risk of recurrence and poor prognosis in SqCC.

scholarly journals Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer

2021 ◽  
Vol Volume 13 ◽  
pp. 8821-8830
Author(s):  
Jingfeng Wang ◽  
Jian Liu ◽  
Longfei Gao ◽  
Guangqiao Li ◽  
Yilin Sun ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Independent Predictor ◽  
Node Metastasis

Activated leukocyte cell adhesion molecule expression predicts lymph node metastasis in oral squamous cell carcinoma

Oral Oncology ◽  
2010 ◽  
Vol 46 (5) ◽  
pp. 393-398 ◽  
Author(s):  
Michiel van den Brand ◽  
Robert P. Takes ◽  
Marianne Blokpoel-deRuyter ◽  
Piet J. Slootweg ◽  
Léon C.L. van Kempen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Adhesion Molecule Expression ◽  
Node Metastasis

Reduced E-Cadherin Expression Is Associated with Increased Lymph Node Metastasis and Unfavorable Prognosis in Non-small Cell Lung Cancer

1998 ◽  
Vol 157 (4) ◽  
pp. 1319-1323 ◽  
Author(s):  
MAARTEN A. SULZER ◽  
MATHIE P. G. LEERS ◽  
JAN A. van NOORD ◽  
EWALD C. M. BOLLEN ◽  
PAUL H. M. H. THEUNISSEN
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Node Metastasis ◽  
E Cadherin
Sign in / Sign up

Export Citation Format

Share Document