scholarly journals Survival rates in patients with low-grade glioma after intraoperative magnetic resonance image guidance

Cancer ◽  
2005 ◽  
Vol 103 (6) ◽  
pp. 1227-1233 ◽  
Author(s):  
Elizabeth B. Claus ◽  
Andres Horlacher ◽  
Liangge Hsu ◽  
Richard B. Schwartz ◽  
Donna Dello-Iacono ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Image ◽  
Image Guidance ◽  
Survival Rates ◽  
Low Grade Glioma ◽  
Low Grade

scholarly journals Dysembryoplastic neuroepithelial tumor and oligodendroglioma: the diagnostic value of magnetic resonance spectroscopy

1998 ◽  
Vol 4 (4) ◽  
pp. E8 ◽  
Author(s):  
Eric W. Sherburn ◽  
Mark M. Bahn ◽  
Murat Gokden ◽  
Daniel L. Silbergeld ◽  
Keith M. Rich
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Treatment Options ◽  
Diagnostic Value ◽  
Low Grade Glioma ◽  
Resonance Spectroscopy ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Low Grade ◽  
Radiological Findings ◽  
Similar Treatment

Preoperative differentiation between dysembryoplastic neuroepithelial tumor (DNT) and low-grade glioma is often not possible. Dysembryoplastic neuroepithelial tumor is a recently described entity of uncertain origin; however, the diagnosis has important clinical implications. Clinical and radiological findings of DNT and low-grade glioma, especially oligodendroglioma, may be similar. Treatment options and prognosis differ significantly between these two lesions; consequently, accurate diagnosis is imperative. The authors describe two individuals who presented simultaneously at their institution: one patient with an oligodendroglioma and a second patient with DNT. The natural history, neurodiagnostic, and pathological features of each are reviewed with special emphasis on the potential utility of magnetic resonance spectroscopy in differentiating these lesions.

scholarly journals Six Immune Associated Genes Construct Prognostic Model Evaluate Low-Grade Glioma

2020 ◽  
Vol 11 ◽  
Author(s):  
Yin Qiu Tan ◽  
Yun Tao Li ◽  
Teng Feng Yan ◽  
Yang Xu ◽  
Bao Hui Liu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Risk Score ◽  
Survival Rates ◽  
Low Grade Glioma ◽  
The Cancer Genome Atlas ◽  
Low Grade ◽  
Sequencing Analysis ◽  
Six Genes ◽  
Genome Atlas ◽  
Overall Survival Rates

BackgroundThe immunotherapy of Glioma has always been a research hotspot. Although tumor associated microglia/macrophages (TAMs) proves to be important in glioma progression and drug resistance, our knowledge about how TAMs influence glioma remains unclear. The relationship between glioma and TAMs still needs further study.MethodsWe collected the data of TAMs in glioma from NCBI Gene Expression Omnibus (GEO) that included 20 glioma samples and 15 control samples from four datasets. Six genes were screened from the Differential Expression Gene through Gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, protein–protein interaction (PPI) network and single-cell sequencing analysis. A risk score was then constructed based on the six genes and patients’ overall survival rates of 669 patients from The Cancer Genome Atlas (TCGA). The efficacy of the risk score in prognosis and prediction was verified in Chinese Glioma Genome Atlas (CGGA).ResultsSix genes, including CD163, FPR3, LPAR5, P2ry12, PLAUR, SIGLEC1, that participate in signal transduction and plasma membrane were selected. Half of them, like CD163, FPR3, SIGLEC1, were mainly expression in M2 macrophages. FPR3 and SIGLEC1 were high expression genes in glioma associated with grades and IDH status. The overall survival rates of the high risk score group was significantly lower than that of the low risk score group, especially in LGG.ConclusionJoint usage of the 6 candidate genes may be an effective method to diagnose and evaluate the prognosis of glioma, especially in Low-grade glioma (LGG).

Surgical treatment of low-grade gliomas in the intraoperative magnetic resonance imager

1998 ◽  
Vol 4 (4) ◽  
pp. E10 ◽  
Author(s):  
Claudia Martin ◽  
Eben Alexander ◽  
Terry Wong ◽  
Richard Schwartz ◽  
Ferenc Jolesz ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Image Guidance ◽  
Intraoperative Imaging ◽  
Radical Resection ◽  
Low Grade ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Low Grade Gliomas ◽  
Surgical Field

Radical resection of low-grade gliomas can decrease the incidence of recurrence, the time to tumor progression, and the incidence of malignant transformation. The authors present a series of 25 patients who underwent craniotomy and resection of low-grade tumor in an intraoperative magnetic resonance (MR) imager. This is an open configuration 0.5-tesla imager developed by The Brigham and Women's Hospital and General Electric, in which a patient can be placed to undergo surgery. Gross-total removal was accomplished under real-time image guidance. These intraoperative images allow definitive localization and targeting of the lesions and accommodate anatomical changes that may occur during surgery. The authors consistently found that the extent of abnormality seen on the intraoperatively obtained films of resection was larger than that apparent in the surgical field of view alone. Intraoperative imaging made accurate surgical identification of these abnormal areas and subsequent resection possible. Patients with tumors adjacent to or within motor or language cortex underwent resection while awake, with monitoring of neurological function. In these cases, an aggressive resection without increased neurological morbidity was accomplished using the image guidance in conjunction with serial testing. A 1-month postoperative MR image was obtained in all patients. These correlated with the final intraoperative images obtained after the resection was completed. Only one patient had a mild postoperative deficit that remained at the 1-month follow-up examination. As the long-term outcome in patients with low-grade gliomas has been shown to correspond to the degree of resection, surgical resection in which intraoperative MR imaging guidance is used can be an invaluable modality in the treatment of these tumors.

scholarly journals Three-Year Survival Rate in All Kinds of Glioma Tumors in One Institution, Iran, 2001-2010

2020 ◽  
Vol 6 (2) ◽  
pp. 67-72
Author(s):  
Masih Rezaee ◽  
◽  
Bahram Amin Mansour ◽  
Keyword(s):  
Survival Rate ◽  
Survival Rates ◽  
Tumor Resection ◽  
High Grade Glioma ◽  
Good Prognosis ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Diffuse Astrocytoma ◽  
And Gender ◽  
Glioma Tumors

Background and Aim: The survival rate of brain tumors has not yet been reported in Iran. The purpose of this study, given the lack of such information, was to evaluate the 3-year survival rate in patients with all kinds of glioma tumors. Methods and Materials/Patients: This study was descriptive and retrospective, including 222 patients who had been diagnosed clinically with one type of glioma tumor and admitted to Al-Zahra hospital, Isfahan, Iran during 2001-2010. All patients (for minors, their parents) were contacted by phone. They were asked about the 3-year survival rate following their tumor resection surgery. Data such as patient’s age on admission, gender, histological diagnosis of tumor, and treatment regimen (surgical/non-surgical, radiation, and/or chemotherapy) were collected from medical records. The 3-year survival rate and frequency of each tumor based on age and gender were measured. Results: The 3-year survival rates for Glioblastoma Multiform (GBM) and anaplastic astrocytoma were 8.7% and 0%, respectively following surgery and chemo-radiation. These tumors were categorized as high-grade glioma with poor prognosis. The 3-year survival rate for diffuse astrocytoma, low-grade oligodendroglioma, low-grade ependymoma, and pilocytic astrocytoma following surgery and radiation were 100%, 95.2%, 100%, and 100%, respectively. These tumors were categorized as low-grade glioma, which has a good prognosis. Conclusion: In this study, the 3-year survival rate in patients with low-grade glioma following surgery and radiation was almost 100%. In contrast, the 3-year survival rate in patients with highgrade glioma following surgery and chemo-radiation was almost 0%.

Respiratory-gated magnetic resonance image guided radiation therapy for hepatocellular carcinoma: A pilot study.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 532-532
Author(s):  
Hyun-Cheol Kang ◽  
Jin Ho Kim ◽  
Eui Kyu Chie
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiation Therapy ◽  
Gastrointestinal Tract ◽  
Magnetic Resonance ◽  
Magnetic Resonance Image ◽  
Survival Rates ◽  
Good Alternative ◽  
Ablative Therapy ◽  
Image Guided Radiation Therapy ◽  
Image Guided

532 Background: Hypofractionated RT has shown encouraging results in hepatocellular carcinoma (HCC) patients. However, HCC adjacent to the gastrointestnal (GI) tract should be carefully treated using the high-precision irradiation technique due to risk of radiation damage. We evaluated the feasibility of a respiratory-gated magnetic resonance image guided radiation therapy (RgMRg-RT) for hepatocellular carcinoma (HCC). Methods: Thirty-three patients with HCC underwent RgMRg-RT in our hospital from 2015 to February 2019, including patients with Child-Pugh A/B7 cirrhosis and unresectable tumors near the gastrointestinal tract. The median radiation dose was 50 Gy (range, 25–60) and median fraction number was 5 (range, 4–15). Gating was performed based on real-time magnetic resonance image without an external surrogate. Results: The median follow-up period was 11.7 months (range, 3.6–37.9 months). The rates of local control of the target tumor at 6 months and 1 year were 90.2 and 86.9%, respectively. The overall survival rates at 6 months, 1, and 2 years were 84.3, 76.3, and 61%, respectively. The median distances from gross tumor to the esophagus, stomach, duodenum and colon were 6.1 (range, 1.9-14.3), 6.4 (0-13.4), 3.8 (0-13.5) and 4cm (0.3-13), respectively. A total of 15 tumors (45.5%) were located within 2 cm of the gastrointestinal tract and 9 tumors (27.3%) within 1cm. Grades 3 treatment‐related bleeding was observed in one patient and one patient had radiation‐induced liver disease. Conclusions: Hypofractionated RgMRg-RT was a safe and potentially ablative therapy for HCC. RgMRg-RT is a good alternative treatment for patients with HCCs that are unsuitable for surgical resection or local ablative therapy.

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