scholarly journals Does the number of lymph nodes examined in patients with lymph node-negative breast carcinoma have prognostic significance?

Cancer ◽  
2005 ◽  
Vol 103 (4) ◽  
pp. 664-671 ◽  
Author(s):  
Joseph K. Salama ◽  
Ruth Heimann ◽  
Fen Lin ◽  
Neil Mehta ◽  
Steven J. Chmura ◽  
...  
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Lymph Nodes ◽  
Prognostic Significance ◽  
Node Negative

A high number of tumor free axillary lymph nodes from patients with lymph node negative breast carcinoma is associated with poor outcome

Cancer ◽  
2002 ◽  
Vol 94 (8) ◽  
pp. 2307-2309 ◽  
Author(s):  
Rosemary R. Millis ◽  
Robert J. Springall ◽  
Andrew M. Hanby ◽  
Kenneth Ryder ◽  
Ian S. Fentiman
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Lymph Nodes ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Negative ◽  
Poor Outcome

scholarly journals Expression of Mesothelial Marker Calretinin in Breast Cancer

2019 ◽  
Vol 4 (01) ◽  
Author(s):  
Dr. Kalathingal Kamarunisha Aboobacker ◽  
Dr. Prema Saldanha
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Breast Carcinoma ◽  
Calcium Binding ◽  
Invasive Carcinoma ◽  
Prognostic Significance ◽  
Immunohistochemical Expression ◽  
Node Negative ◽  
Mastectomy Specimen ◽  
Grade 3

Calretinin (CR) is a calcium binding protein of calmodulin superfamily, a widely used marker for mesothelial differentiation. It is also found to be expressed in breast carcinoma. Breast carcinoma is the leading cause of cancer death in women and despite new approaches and advances, it is still difficult to predict the behaviour of the tumour and its prognosis. So there is a need and struggle to identify new markers for prognosis of breast cancer. The study is aimed at evaluating the frequency of Calretinin expression in breast carcinoma and assessing the characteristics of Calretinin positive tumours. Thirty mastectomy specimen of invasive breast carcinoma were analysed histopathologically and for immunohistochemical expression of ER, PR, HER2/neu and Calretinin. In this study 93.33% (28 cases) were of invasive carcinoma, NST and 6.67% were of other subtypes. Patients less than 40 years of age showed low CR expression and patients over 40 showed high CR expression (p = 0.22). Grade 3 tumours showed high CR, grades 1 and 2 showed low CR expression. Lymph node positive cases showed high CR and lymph node negative cases showed low CR. Tumours less than 5cms in size show low CR expression and those over 5cms showed high CR expression (p = 0.38). Negative ER, PR and HER2/neu showed high CR expression. CR expression was high in 54.5% of basal-like subtype and 66.7% of HER2-enriched.CR expression was low in 50% of luminal cases. High Calretinin expression was seen in grade 3, HER2-enriched and basal-like subtypes of breast cancer which may be of considerable prognostic significance.

scholarly journals A comparative study to evaluate the efficacy of the USG and USG guided FNAC of axillary lymph node of carcinoma breast in clinically node negative cases

2017 ◽  
Vol 4 (5) ◽  
pp. 1614
Author(s):  
Ramesh H. ◽  
Praveen K. N. ◽  
Akshay V. Gokak ◽  
Abhijit D. H.
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Comparative Study ◽  
Lymph Nodes ◽  
Axillary Lymph Node ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Reliable Technique ◽  
Node Negative ◽  
Negative Predictor

Background: Breast cancer remains the most common malignancy among women and accounts for 32% of all cancers in women. The average age of developing cancer is shifted from 50-70 years to 30-50 years. Cancers in young tend to be more aggressive. In the absence of distant metastasis, assessment of axillary status is the important part of initial staging process because of its subsequent importance in management. And the absence of presence or absence of axillary metastasis is the strongest prognostic indicator available for breast carcinoma. The objectives were to assess the accuracy USG and USG guided FNAC of axillary lymph nodes of carcinoma breasts in clinically node negative cases and to determine USG guided FNAC can be used to detect axillary lymph nodes metastasis.Methods: This was a comparative study conducted at KIMS Hospital from November 2013 to November 2015. All the patients with clinically node negative carcinoma breasts were evaluated with USG Axilla and those found to be having lymph nodes were subjected to USG guided FNAC and these were correlated with the HPR report.Results: A total 12 patients who satisfied the inclusion criteria were included in study. The most common age group involved in this study was 30-40 years. Upper outer quadrant was the most common location of the group. The sensitivity of the USG in detecting axillary lymph node was 50%, specificity 75%, positive predictor value 805, negative predictor value 42.8% and accuracy of 58.3%. Sensitivity of USG guided FNAC was 50%, specificity 100%, positive predictor value 100%, negative predictor value 50% and accuracy of 66.6%.Conclusions: In conclusion USG-FNAC of axillary lymph node is a simple, minimally invasive and reliable technique for the initial determination of ALN status in patients with breast carcinoma. In present study, the PPV of 100% and NPV of 50% indicate that the predictor power of a positive result is excellent but as expected a negative result is less helpful.

Prognostic significance of lymph node retrieval in localized rectal cancer (RC): A registry analysis of 8,964 patients (pts).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 3566-3566
Author(s):  
Amandeep Gill ◽  
Ann Brunson ◽  
Primo Lara ◽  
Kristin Olson ◽  
Arta Monjazeb ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Early Stage ◽  
Prognostic Significance ◽  
Cox Proportional Hazards ◽  
Node Number ◽  
Node Negative ◽  
T Stage ◽  
Lymph Node Retrieval ◽  
Positive Lymph Nodes

3566 Background: In contrast to colon cancer, the prognostic implications of reduced lymph node retrieval in RC are unclear. We investigated the association between the total number of lymph nodes examined in early stage RC and disease specific survival (DSS) in two cohorts: 1) pts who underwent surgery and adjuvant (ADJ) chemoradiation (chemoXRT), and 2) those who received neoadjuvant (NEO) chemoXRT. Methods: Using the California Cancer Registry, we identified 8,946 pts with stage I – III RC diagnosed from 2000 to 2007. Of these, 4,790 underwent tri-modality therapy: 2,946 patients (61.5%) had NEO chemoXRT and 1,844 patients (38.5%) had ADJ chemoXRT. Multivariate Cox proportional hazards models were constructed for DSS, adjusting for age, sex, race, socioeconomic status, T-stage and lymph node number. DSS was compared between NEO and ADJ cohorts within separate subgroups of pathologic node positive and node negative RC. Results: Although there was no difference in overall DSS between the NEO and ADJ cohorts, the median number of lymph nodes examined was reduced in patients who had undergone NEO chemoXRT (8 vs. 11, p<0.0001). For all pts treated with tri-modality therapy, advancing age and higher T-stage were associated with significantly reduced DSS. Positive lymph nodes were associated with worse DSS regardless of the timing of therapy, although the effect was stronger for residual lymph nodes in the NEO cohort (HR 2.8 vs. 1.8 in ADJ cohort, p<0.001). For node negative pts in the ADJ cohort, increased lymph node retrieval was associated with improved DSS (HR per node 0.952, p=0.017); however, no association between lymph nodes examined and DSS was seen in the NEO cohort (p=0.282). Conclusions: Residual positive lymph nodes in pts treated with NEO chemoXRT are more strongly associated with poorer DSS than in pts treated with surgery and ADJ chemoXRT. NEO chemoXRT dissociates the connection between lymph node retrieval and survival in RC. This finding highlights a key difference between colon and RC and underscores the need for a different interpretation of the pathologic findings after NEO therapy.

Prognostic significance of microvessel density in lymph node negative breast carcinoma

1995 ◽  
Vol 26 (11) ◽  
pp. 1181-1184 ◽  
Author(s):  
Patrick Costello ◽  
Amanda McCann ◽  
Desmond N Carney ◽  
Peter A Dervan
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Microvessel Density ◽  
Prognostic Significance ◽  
Node Negative

scholarly journals The Prognostic Value of Lymph Nodes Dissection Number on Survival of Patients with Lymph Node-Negative Gastric Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Wu Song ◽  
Yujie Yuan ◽  
Liang Wang ◽  
Weiling He ◽  
Xinhua Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Tumor Invasion ◽  
Prognostic Value ◽  
Operation Time ◽  
Invasion Depth ◽  
Node Negative ◽  
Tumor Invasion Depth

Objective.The study was designed to explore the prognostic value of examined lymph node (LN) number on survival of gastric cancer patients without LN metastasis.Methods.Between August 1995 and January 2011, 300 patients who underwent gastrectomy with D2 lymphadenectomy for LN-negative gastric cancer were reviewed. Patients were assigned to various groups according to LN dissection number or tumor invasion depth. Some clinical outcomes, such as overall survival, operation time, length of stay, and postoperative complications, were compared among all groups.Results.The overall survival time of LN-negative GC patients was50.2±30.5months. Multivariate analysis indicated that LN dissection number(P<0.001)and tumor invasion depth(P<0.001)were independent prognostic factors of survival. The number of examined LNs was positively correlated with survival time(P<0.05)in patients with same tumor invasion depth but not correlated with T1 stage or examined LNs>30. Besides, it was not correlated with operation time, transfusion volume, length of postoperative stay, or postoperative complication incidence(P>0.05).Conclusions.The number of examined lymph nodes is an independent prognostic factor of survival for patients with lymph node-negative gastric cancer. Sufficient dissection of lymph nodes is recommended during surgery for such population.

Sign in / Sign up

Export Citation Format

Share Document