scholarly journals Brain metastases of malignant germ cell tumors in children and adolescents

Cancer ◽  
2004 ◽  
Vol 101 (3) ◽  
pp. 620-626 ◽  
Author(s):  
Sheri L. Spunt ◽  
Michael F. Walsh ◽  
Matthew J. Krasin ◽  
Kathleen J. Helton ◽  
Catherine A. Billups ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Germ Cell ◽  
Children And Adolescents ◽  
Germ Cell Tumors ◽  
Malignant Germ Cell Tumors

scholarly journals Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group

2017 ◽  
Vol 35 (11) ◽  
pp. 1203-1210 ◽  
Author(s):  
Furqan Shaikh ◽  
John W. Cullen ◽  
Thomas A. Olson ◽  
Farzana Pashankar ◽  
Marcio H. Malogolowkin ◽  
...  
Keyword(s):  
Germ Cell ◽  
Children And Adolescents ◽  
Statistical Significance ◽  
Germ Cell Tumors ◽  
Stage I ◽  
Stage Ii ◽  
Intermediate Risk ◽  
Historical Cohort ◽  
Number Of Cycles ◽  
Malignant Germ Cell Tumors

Purpose To investigate whether event-free survival (EFS) can be maintained among children and adolescents with intermediate-risk (IR) malignant germ cell tumors (MGCT) if the administration of cisplatin, etoposide, and bleomycin (PEb) is reduced from four to three cycles and compressed from 5 to 3 days per cycle. Patients and Methods In a phase 3, single-arm trial, patients with IR MGCT (stage II-IV testicular, II-III ovarian, I-II extragonadal, or stage I gonadal tumors with subsequent recurrence) received three cycles of PEb. A parametric comparator model specified that the observed EFS rate should not be significantly < 92%. As recommended for trials that test a reduction of therapy, a one-sided P value ≤ .10 was used to indicate statistical significance. In a post hoc analysis, we also compared results to the EFS rate of comparable patients treated with four cycles of PEb in two prior studies. Results Among 210 eligible patients enrolled from 2003 to 2011, 4-year EFS (EFS4) rate was 89% (95% confidence interval, 83% to 92%), which was significantly lower than the 92% threshold of the comparison model ( P = .08). Among 181 newly diagnosed patients, the EFS4 rate was 87%, compared with 92% for 92 comparable children in the historical cohort ( P = .15). The EFS4 rate was significantly associated with stage (stage I, 100%; stage II, 92%; stage III, 85%; and stage IV, 54%; P < .001). Conclusion The EFS rate for children with IR MGCT observed after three cycles of PEb was less than that of a prespecified parametric model, particularly for patients with higher-stage tumors. These data do not support a reduction in the number of cycles of PEb from four to three. However, further investigation of a reduction in the number of cycles for patients with lower-stage tumors is warranted.

Outcome and staging evaluation in malignant germ cell tumors of the ovary in children and adolescents: an intergroup study

2004 ◽  
Vol 39 (3) ◽  
pp. 424-429 ◽  
Author(s):  
D Billmire ◽  
C Vinocur ◽  
F Rescorla ◽  
B Cushing ◽  
W London ◽  
...  
Keyword(s):  
Germ Cell ◽  
Children And Adolescents ◽  
Germ Cell Tumors ◽  
Malignant Germ Cell Tumors

scholarly journals Treatment outcome of patients with brain metastases from malignant germ cell tumors

Cancer ◽  
1999 ◽  
Vol 85 (4) ◽  
pp. 988-997 ◽  
Author(s):  
Sophie D. Foss� ◽  
Carsten Bokemeyer ◽  
Arthur Gerl ◽  
Stephane Culine ◽  
William G. Jones ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Brain Metastases ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Malignant Germ Cell Tumors

scholarly journals Malignant germ cell tumors in 57 children and adolescents

Cancer ◽  
1981 ◽  
Vol 48 (8) ◽  
pp. 1890-1898 ◽  
Author(s):  
Garrett M. Brodeur ◽  
Cathryn B. Howarth ◽  
Charles B. Pratt ◽  
Josefina Caces ◽  
H. Omar Hustu
Keyword(s):  
Germ Cell ◽  
Children And Adolescents ◽  
Germ Cell Tumors ◽  
Malignant Germ Cell Tumors

scholarly journals Neurological complications of malignant germ cell tumors of testis.Biology of brain metastases (I)

Cancer ◽  
1979 ◽  
Vol 44 (6) ◽  
pp. 2349-2353 ◽  
Author(s):  
Davor Vugrin ◽  
Esteban Cvitkovic ◽  
Jerome Posner ◽  
Steven Hajdu ◽  
Robert B. Golbey
Keyword(s):  
Brain Metastases ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Neurological Complications ◽  
Malignant Germ Cell Tumors

Brain Metastases from Malignant Germ Cell Tumors of the Testis: Our Experience of 5 Cases with a Review of the Literature

2007 ◽  
Vol 1 (4) ◽  
pp. 169-173
Author(s):  
Toshifumi Kurahashi ◽  
Hideaki Miyake ◽  
Masafumi Kumano ◽  
Mototsugu Muramaki ◽  
Atsushi Takenaka ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Review Of The Literature ◽  
Malignant Germ Cell Tumors
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