scholarly journals Better prediction of prognosis for patients with nasopharyngeal carcinoma using primary tumor volume

Cancer ◽  
2004 ◽  
Vol 100 (10) ◽  
pp. 2160-2166 ◽  
Author(s):  
Mu-Kuan Chen ◽  
Tony Hsiu-Hsi Chen ◽  
Jen-Pei Liu ◽  
Cheng-Chuan Chang ◽  
Wei-Chu Chie
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Primary Tumor ◽  
Tumor Volume ◽  
Primary Tumor Volume ◽  
Prediction Of Prognosis

Haptoglobin Genotypes in Nasopharyngeal Carcinoma

2009 ◽  
Vol 24 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Ching-Chih Lee ◽  
Hon-Yi Lin ◽  
Shih-Kai Hung ◽  
Dian-Kun Li ◽  
Hsu-Chueh Ho ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Prognostic Factor ◽  
Nasopharyngeal Carcinoma ◽  
Primary Tumor ◽  
Tumor Volume ◽  
Prognostic Significance ◽  
Chain Reaction ◽  
Primary Tumor Volume ◽  
Negative Prognostic Factor ◽  
Polymerase Chain

Aim Haptoglobin polymorphisms are associated with different cancers; however, the occurrence of nasopharyngeal carcinoma (NPC) in relation to haptoglobin polymorphisms has not been reported. In this study, the distribution of haptoglobin genotypes among patients with NPC was investigated and the prognostic significance of haptoglobin genotypes was further analyzed. Material and methods Haptoglobin genotypes were analyzed using polymerase chain reaction and electrophoresis. The genotypes were determined in the sera of 49 NPC patients and in 134 controls. Results The haptoglobin genotypes of patients with NPC were as follows: Hp 1–1, 2%; Hp 2–1, 39%; Hp 2–2, 59%. The frequency of the Hp 2–2 genotype was much higher in NPC patients than in control individuals (p=0.044). Furthermore, NPC patients with the Hp 2–2 genotype had advanced T stages (p=0.001) and larger primary tumor volumes (p=0.035) than those with Hp 2–1 or 1–1. Conclusion An increased frequency of the Hp 2–2 genotype was associated with NPC. The Hp 2 allele was also overexpressed in NPC patients. NPC patients with the Hp 2–2 genotype had advanced T stage and a larger primary tumor volume. Hp 2–2 may be a negative prognostic factor in NPC.

Primary tumor volume of nasopharyngeal carcinoma: Significance for survival

2008 ◽  
Vol 35 (3) ◽  
pp. 376-380 ◽  
Author(s):  
Ching-Chih Lee ◽  
Hsu-Chueh Ho ◽  
Moon-Sing Lee ◽  
Shih-Hsuan Hsiao ◽  
Juen-Haur Hwang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Primary Tumor ◽  
Tumor Volume ◽  
Primary Tumor Volume

scholarly journals Primary Tumor Volume of Nasopharyngeal Carcinoma: Significance for Recurrence and Survival

2008 ◽  
Vol 71 (9) ◽  
pp. 461-466 ◽  
Author(s):  
Sau-Tung Chu ◽  
Pi-Hsiung Wu ◽  
Yu-Yi Hou ◽  
Kuo-Ping Chang ◽  
Chao-Chuan Chi ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Primary Tumor ◽  
Tumor Volume ◽  
Primary Tumor Volume

Primary Tumor Volume Measured by FDG PET and CT in Nasopharyngeal Carcinoma

2011 ◽  
Vol 36 (6) ◽  
pp. 447-451 ◽  
Author(s):  
Guang-Uei Hung ◽  
Iuan-Sheng Wu ◽  
Hong-Shen Lee ◽  
Weir-Chiang You ◽  
Hui-Chuan Chen ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Primary Tumor ◽  
Fdg Pet ◽  
Tumor Volume ◽  
Primary Tumor Volume

scholarly journals THE ASSOCIATION BETWEEN EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR WITH PRIMARY TUMOR VOLUME OF NASOPHARYNGEAL CARCINOMA

2019 ◽  
Vol 1 (1) ◽  
pp. 36-40
Author(s):  
Audi Wahyu Utomo ◽  
Indah Asmara Gustarini
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Nasopharyngeal Carcinoma ◽  
Primary Tumor ◽  
Tumor Volume ◽  
Growth Factor Receptor ◽  
Primary Tumor Volume ◽  
Positive Expression ◽  
Egfr Expression ◽  
Epidermal Growth

Objective: Tumor development was triggered by the excess population of the Epidermal Growth Factor Receptor (EGFR). Expression of EGFR with primary tumor volume of in patients with NPC. Expression of EGFR has a role in the increasing of metastasis, self-renewal, drug resistance and anti-apoptosis. EGFR expression associated with tumors size, positively nodules and advanced tumor stage in NPC patients. High level of EGFR expression by immunohistochemical examination associated with the development, progression and differentiation cell of tumors. Methods: Using Cross-sectional as study design. Formalin-fixed paraffin-embedded biopsy specimens were obtained. The expression of EGFR was studied with immunohistochemistry using EGFR polyclonal antibody (Bioss, USA). Assessment of the staining was performed by pathologist consultant used histoscore. The Pearson’s correlation test was used to determine the correlation between expression of EGFR and primary tumor volume of nasopharyngeal carcinoma. Statistical significance was defined as p <0.05. Result: Total samples are 19 patients. The result of EGFR expression in NPC patients with a primary tumor volume of 1-50 ml is 5 samples with a weak positive expression and 4 samples with moderate positive expression. NPC with a primary tumor volume of 51-100 ml is 2 samples of negative expression, 1 sample of weak positive expression, 3 samples with moderate positive expression and 2 samples with strong positive expression. NPC with primary tumor volume >100 ml is 1 sample weak positive expression and 1 sample strong positive expression. Statistical analysis using Pearson’s exact test was obtained p=0.047 with a correlation coefficient 0.461. EGFR expression from all of the patients there was 2 samples (10.53%) negatives, 7 samples (36.84%) weak positive, moderate positive was 7 samples (36.84%), and strong positive 3 samples (15.79%).  Conclusion: There was an association between the expression of EGFR with the primary tumor volume of nasopharyngeal carcinoma.

Primary tumor volume calculation as a predictive factor of prognosis in nasopharyngeal carcinoma

2008 ◽  
Vol 128 (1) ◽  
pp. 93-97 ◽  
Author(s):  
Ching-Chih Lee ◽  
Sau-Tung Chu ◽  
Hsu-Chueh Ho ◽  
Ching-Chieh Lee ◽  
Shih-Kai Hung
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Predictive Factor ◽  
Primary Tumor ◽  
Tumor Volume ◽  
Volume Calculation ◽  
Primary Tumor Volume
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