scholarly journals Zoledronic acid delays the onset of skeletal-related events and progression of skeletal disease in patients with advanced renal cell carcinoma

Cancer ◽  
2004 ◽  
Vol 100 (9) ◽  
pp. 1987-1988 ◽  
Author(s):  
Bruno Vincenzi ◽  
Daniele Santini ◽  
Annalisa La Cesa ◽  
Giuseppe Tonini
Keyword(s):  
Renal Cell Carcinoma ◽  
Zoledronic Acid ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Advanced Renal Cell Carcinoma ◽  
Skeletal Disease ◽  
Skeletal Related Events

scholarly journals A phase II study of palliative radiotherapy combined with zoledronic acid hydrate for metastatic bone tumour from renal cell carcinoma

2020 ◽  
Vol 51 (1) ◽  
pp. 100-105
Author(s):  
Hideyuki Harada ◽  
Naoto Shikama ◽  
Hitoshi Wada ◽  
Nobue Uchida ◽  
Miwako Nozaki ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Zoledronic Acid ◽  
Bone Metastases ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Palliative Radiotherapy ◽  
Level Increase ◽  
Skeletal Related Events ◽  
Acid Hydrate ◽  
Skeletal Related Event

Abstract Purpose Palliative radiotherapy is the standard of care for bone metastases. However, skeletal-related events, defined as a pathologic fracture, paraplegia, surgery or radiotherapy for local recurrence, or severe pain in previously irradiated bone with radio-resistant histology type still present high incidence. The primary objective of this study was to determine whether zoledronic acid hydrate and palliative radiotherapy could prevent local skeletal-related events. Methods Eligible patients with bone metastases from renal cell carcinoma were treated with zoledronic acid hydrate every 3 or 4 weeks and concurrent palliative radiotherapy of 30 Gy in 3 Gy fractions. The criteria for radiotherapy were established by the treating physician, but patients with complicated bone metastases (impending pathological fracture or spinal cord compression) which needed immediate surgery were excluded. The primary endpoint was the local skeletal-related event-free survival rate at 1 year. Results Twenty-seven patients were included in the study. The median age was 65 (range, 50–84) years. Radiotherapy dose was 30 Gy for all patients except 1 whose radiotherapy was terminated due to brain metastasis progression at 18 Gy. Zoledronic acid hydrate was administered in a median of 12 (range, 0–34) times. The median follow-up period was 12 months and 19 months in patients who were still alive. Of 27 patients in the efficacy analysis, the 1-year local skeletal-related event-free rate was 77.6% (80% confidence interval, 66.2–89.0). Common grade 3 toxicities were hypocalcemia (1 [4%]), sGPT level increase (1 [4%]) and sGOT level increase (1 [4%]). There was no grade 4 or 5 toxicity. Conclusion Zoledronic acid hydrate administration and palliative radiotherapy were a well-tolerated and promising treatment reducing skeletal-related events for bone metastases from renal cell carcinoma.

scholarly journals ZOLEDRONIC ACID FOR BONE METASTASES DUE TO ADVANCED RENAL CELL CARCINOMA UNDER CHRONIC HEMODIALYSIS

2008 ◽  
Vol 99 (5) ◽  
pp. 660-665 ◽  
Author(s):  
Satoshi Arima ◽  
Ryoichi Shiroki ◽  
Shintaro Mori ◽  
Takahiro Maruyama ◽  
Hitomi Sasaki ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Zoledronic Acid ◽  
Bone Metastases ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chronic Hemodialysis ◽  
Advanced Renal Cell Carcinoma

MP-14.13: Clinical Evaluation of Zoledronic Acid on Bone Metastases Lesions of Advanced Renal Cell Carcinoma

Urology ◽  
2009 ◽  
Vol 74 (4) ◽  
pp. S112
Author(s):  
R. Shiroki ◽  
T. Maruyama ◽  
M. Kusaka ◽  
N. Satoh ◽  
K. Hayakawa ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Zoledronic Acid ◽  
Bone Metastases ◽  
Cell Carcinoma ◽  
Clinical Evaluation ◽  
Renal Cell ◽  
Advanced Renal Cell Carcinoma
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