scholarly journals Expression of steroid receptor coactivators and corepressors in human endometrial hyperplasia and carcinoma with relevance to steroid receptors and Ki-67 expression

Cancer ◽  
2003 ◽  
Vol 98 (10) ◽  
pp. 2207-2213 ◽  
Author(s):  
Junko Uchikawa ◽  
Tanri Shiozawa ◽  
Hsien-Chang Shih ◽  
Tsutomu Miyamoto ◽  
Yu-Zhen Feng ◽  
...  
Keyword(s):  
Endometrial Hyperplasia ◽  
Steroid Receptors ◽  
Steroid Receptor ◽  
Ki 67 ◽  
Steroid Receptor Coactivators

scholarly journals Steroid Receptor Coactivator Expression throughout the Menstrual Cycle in Normal and Abnormal Endometrium

2002 ◽  
Vol 87 (6) ◽  
pp. 2960-2966 ◽  
Author(s):  
Christopher W. Gregory ◽  
Elizabeth M. Wilson ◽  
K. B. C. Apparao ◽  
Ruth A. Lininger ◽  
William R. Meyer ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Endometrial Hyperplasia ◽  
Clomiphene Citrate ◽  
Expression Patterns ◽  
Steroid Receptor ◽  
Male Factor ◽  
Steroid Receptor Coactivator ◽  
Additional Group ◽  
Steroid Receptor Coactivators ◽  
Fertile Women

The endometrium of reproductive aged women undergoes cyclic developmental changes in preparation for implantation in response to estrogen and progesterone. These steroids and their receptors are tightly regulated throughout the menstrual cycle, and their actions are facilitated by the presence of steroid receptor coactivators of the p160 family. In this study using immunohistochemistry and Western blot analysis, we characterize the expression patterns of three coactivators, steroid receptor coactivator-1, amplified in breast cancer-1 (AIB1), and transcriptional intermediary factor-2 in human endometrium obtained prospectively from normal fertile women throughout the menstrual cycle. With the exception of glandular AIB1, which increased in the late secretory phase, none of the coactivators changed significantly during the menstrual cycle. We compared coactivator expression patterns in fertile endometrium to the endometrium of anovulatory (proliferative; n = 3) and clomiphene-induced ovulatory (secretory; n = 13) women with polycystic ovarian syndrome (PCOS), a group that have a higher likelihood of developing estrogen-induced endometrial hyperplasia and cancer. To control for the effect of clomiphene citrate, an additional group was included consisting of ovulatory women treated with clomiphene citrate for “male factor” infertility. Compared with both fertile and infertile controls, PCOS women exhibited elevated levels of AIB1 and transcriptional intermediary factor-2 expression in both epithelial and stromal cells. We postulate that increased coactivator expression may render the endometrium more sensitive to estrogen. In support of this, we describe an increased expression of ERα (an estrogen-induced gene product) during the menstrual cycle in PCOS endometrium compared with fertile controls. In summary, we demonstrate that the expression of p160 coactivators are regulated in endometrium during the menstrual cycle in normal fertile women but are overexpressed in the endometrium of women with PCOS. Based on these findings, we suggest a possible mechanism to explain the poor reproductive performance observed in PCOS and the increased incidence of endometrial hyperplasia and cancer noted in this group of women.

Regulation of bovine and ovine lymphocyte proliferation by progesterone: modulation by steroid receptor antagonists and physiological status

1993 ◽  
Vol 129 (6) ◽  
pp. 532-535 ◽  
Author(s):  
Victor H Monterroso ◽  
Peter J Hansen
Keyword(s):  
Lymphocyte Proliferation ◽  
Steroid Receptors ◽  
Steroid Receptor ◽  
Physiological Status ◽  
Inhibitory Effects ◽  
Receptor Antagonists ◽  
Lactating Cows

Lectin-stimulated sheep and cow lymphocytes were used to test whether inhibitors of classical steroid receptors block suppressive effects of progesterone and whether effects of progesterone vary with physiological status. Neither RU 38486 nor RU 43044 blocked the inhibitory effects of progesterone on lymphocyte proliferation. Rather, these antagonists were themselves inhibitory. Effects of progesterone and antagonists were additive: the percentage inhibition caused by progesterone was similar whether antagonists were present or not. The degree of lymphocyte proliferation and the inhibitory effects of progesterone were of the same magnitude for pregnant/lactating cows, pregnant/non-lactating cows, postpartum/lactating cows and cyclic/non-lactating cows. In conclusion, progesterone does not appear to inhibit lymphocyte proliferation through actions that involve classical steroid receptors. There was no evidence that lymphocyte proliferation in the cow is suppressed during pregnancy or that the inhibitory effects of progesterone increase during pregnancy.

206. Regulation of steroid receptors in human endometrial hyperplasia and carcinoma

1978 ◽  
Vol 9 (9) ◽  
pp. 856
Author(s):  
R. Vihko ◽  
O. Jänne ◽  
A. Kauppila ◽  
K. Kontula ◽  
P. Syrjälä
Keyword(s):  
Endometrial Hyperplasia ◽  
Steroid Receptors

scholarly journals Markers of steroid receptor, kinase signalling pathways and Ki-67 expression in relation to tamoxifen sensitivity and resistance

2020 ◽  
Vol 1 ◽  
pp. 29-29
Author(s):  
Christine Campbell ◽  
John Mathew ◽  
Ian O. Ellis ◽  
Ian Bradbury ◽  
Signe Borgquist ◽  
...  
Keyword(s):  
Steroid Receptor ◽  
Signalling Pathways ◽  
Receptor Kinase ◽  
Ki 67 ◽  
Tamoxifen Sensitivity

A new approach to the quality control of steroid receptor assays.

1988 ◽  
Vol 34 (10) ◽  
pp. 2076-2079
Author(s):  
M Borsotti ◽  
M Quercioli ◽  
R D'Ettole ◽  
A Piffanelli ◽  
G Messeri
Keyword(s):  
Quality Control ◽  
Sample Preparation ◽  
Steroid Receptors ◽  
Menopausal Status ◽  
Steroid Receptor ◽  
Usual Practice ◽  
New Approach ◽  
Breast Tumor Tissue ◽  
Consensus Mean ◽  
Receptor Assays

Abstract Lyophilized cytosols prepared from calf uterus and human breast tumor tissue are commonly used to assess the reliability of routine steroid receptor assays. However, preanalytical error (sample preparation, storage, homogenization) cannot be detected in this way. Participating laboratories were asked to mail us all their receptor results obtained over a four-month interval, and to include some information about the patients involved (age, menopausal status, nodal status). After verifying the homogeneity of the populations investigated, we computed consensus means for the percentages of positive samples and for their absolute value. Despite the homogeneity of the characteristics of the populations studied, results from some laboratories systematically differed from the consensus mean. This approach to the quality control of steroid receptors allows evaluation of the whole procedure, from sample preparation to analysis, and thus may be helpful as an addition to the usual practice of distribution of cytosols and tissue powders for assay.

scholarly journals Aromatase Inhibitors as Adjuvant Treatment for ER/PgR Positive Stage I Endometrial Carcinoma: A Retrospective Cohort Study

2020 ◽  
Vol 21 (6) ◽  
pp. 2227
Author(s):  
Laura Paleari ◽  
Mariangela Rutigliani ◽  
Giacomo Siri ◽  
Nicoletta Provinciali ◽  
Nicoletta Colombo ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Aromatase Inhibitors ◽  
Randomized Clinical Trials ◽  
Steroid Receptors ◽  
Reference Group ◽  
Early Stage ◽  
Myometrial Invasion ◽  
Steroid Hormone Receptors ◽  
Stage I ◽  
Ki 67

Objective: Although endometrial cancer (EC) is a hormone dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. The purpose of this study was to explore the effect of adjuvant aromatase inhibitors (AIs) on progression-free survival (PFS) and overall survival (OS) in patients with early stage and steroid receptors-positive EC. Methods: We retrospectively analyzed clinical and pathological factors in 73 patients with high-risk (49.3%) or low-risk (50.7%) stage I (n = 71) or II (n = 2) endometrial cancer who received by their preference after counseling either no treatment (reference group) or AI. Prognostic factors were well balanced between groups. Expression of estrogen receptor (ER), progesterone receptor (PgR), and Ki-67 index was correlated with clinical outcomes. Results: Univariate and multivariate Cox proportional regression analyses, adjusted for age, grade, stage, depth of myometrial invasion, lymphovascular space invasion, BMI, ER, PgR and Ki-67 labeling index levels, showed that PFS and OS had a trend to be longer in patients receiving AI than in the reference group HR= 0.23 (95% CI; 0.04–1.27) for PFS and HR= 0.11 (95% CI; 0.01–1.36) for OS. Conclusion: Compared with no treatment, AI exhibited a trend toward a benefit on PFS and OS in patients with early stage hormone receptor-positive EC. Given the exploratory nature of our study, randomized clinical trials for ER/PgR positive EC patients are warranted to assess the clinical benefit of AI and the potential predictive role of steroid receptors and Ki-67.

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